ID V6JFY1_STRNV Unreviewed; 559 AA.
AC V6JFY1;
DT 19-FEB-2014, integrated into UniProtKB/TrEMBL.
DT 19-FEB-2014, sequence version 1.
DT 24-JAN-2024, entry version 42.
DE RecName: Full=IclR family transcriptional regulator {ECO:0008006|Google:ProtNLM};
GN ORFNames=M877_37510 {ECO:0000313|EMBL:EST18735.1};
OS Streptomyces niveus NCIMB 11891.
OC Bacteria; Actinomycetota; Actinomycetes; Kitasatosporales;
OC Streptomycetaceae; Streptomyces.
OX NCBI_TaxID=1352941 {ECO:0000313|EMBL:EST18735.1, ECO:0000313|Proteomes:UP000017971};
RN [1] {ECO:0000313|EMBL:EST18735.1, ECO:0000313|Proteomes:UP000017971}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=NCIMB 11891 {ECO:0000313|EMBL:EST18735.1,
RC ECO:0000313|Proteomes:UP000017971};
RX PubMed=24407644;
RA Flinspach K., Ruckert C., Kalinowski J., Heide L., Apel A.K.;
RT "Draft Genome Sequence of Streptomyces niveus NCIMB 11891, Producer of the
RT Aminocoumarin Antibiotic Novobiocin.";
RL Genome Announc. 2:e01146-e01113(2014).
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:EST18735.1}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; AWQW01000302; EST18735.1; -; Genomic_DNA.
DR AlphaFoldDB; V6JFY1; -.
DR PATRIC; fig|1352941.4.peg.7605; -.
DR eggNOG; COG1414; Bacteria.
DR HOGENOM; CLU_519641_0_0_11; -.
DR Proteomes; UP000017971; Chromosome.
DR GO; GO:0003677; F:DNA binding; IEA:InterPro.
DR GO; GO:0046278; P:3,4-dihydroxybenzoate metabolic process; IEA:InterPro.
DR GO; GO:0045893; P:positive regulation of DNA-templated transcription; IEA:InterPro.
DR Gene3D; 3.30.450.40; -; 2.
DR Gene3D; 1.10.10.10; Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain; 2.
DR InterPro; IPR029016; GAF-like_dom_sf.
DR InterPro; IPR012794; PcaR_PcaU.
DR InterPro; IPR014757; Tscrpt_reg_IclR_C.
DR InterPro; IPR005471; Tscrpt_reg_IclR_N.
DR InterPro; IPR036388; WH-like_DNA-bd_sf.
DR InterPro; IPR036390; WH_DNA-bd_sf.
DR NCBIfam; TIGR02431; pcaR_pcaU; 1.
DR PANTHER; PTHR30136; HELIX-TURN-HELIX TRANSCRIPTIONAL REGULATOR, ICLR FAMILY; 1.
DR PANTHER; PTHR30136:SF34; TRANSCRIPTIONAL REGULATORY PROTEIN; 1.
DR Pfam; PF09339; HTH_IclR; 2.
DR Pfam; PF01614; IclR; 2.
DR SMART; SM00346; HTH_ICLR; 2.
DR SUPFAM; SSF55781; GAF domain-like; 2.
DR SUPFAM; SSF46785; Winged helix' DNA-binding domain; 2.
DR PROSITE; PS51077; HTH_ICLR; 1.
DR PROSITE; PS51078; ICLR_ED; 2.
PE 4: Predicted;
KW Transcription {ECO:0000256|ARBA:ARBA00023163};
KW Transcription regulation {ECO:0000256|ARBA:ARBA00023015}.
FT DOMAIN 88..278
FT /note="IclR-ED"
FT /evidence="ECO:0000259|PROSITE:PS51078"
FT DOMAIN 308..368
FT /note="HTH iclR-type"
FT /evidence="ECO:0000259|PROSITE:PS51077"
FT DOMAIN 369..550
FT /note="IclR-ED"
FT /evidence="ECO:0000259|PROSITE:PS51078"
FT REGION 1..24
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 559 AA; 59375 MW; 848ED4456376FF17 CRC64;
MPEAMPVDLP DETSAAPGPY SPPPEAVGPL MRGIAVLREA GDAGGRVPLS DLVRSTGLAR
STVDRIAATF ARMGYVRVDG HWLTLAPRLM ELGNAYLAAL RLPALLGPLA ERLADELDES
VSLAVPDGDG IRFVHQSTRR RTMSLTFRIG DLLPAERTAP GPLFATDWDE RDWTRWRARR
AADPEGRSFP AAPPRADTVP DLAGRVADEG GRGVGIDDQL IEPGLVAIAV PVRAPDGTIA
CALSAVSHTS RHSAASLRKA LLPRVRKAAG EMERVLREPP PPAAGGPSAA GLADWTSATK
QELGAGFVES LARGLTVVTA FGEDRPELTL SAVAEATGLA RATARRALIT LEHLGHVTSA
GRTFRLTPRV LALGYPSLSR TTLAEIATPH LAALVQRVHD SASLAVLVGD DIQYTARVST
TRIMSVNISL GTRFPAYAAS MGRVLLADRP PARRLPATEL KPLTPRTTTD PAQLAALLDQ
VADQGHALVD EELEEGLRSL AVPVRDRTGR AVAALNVAMH SSRRTVEECL TDLLPELRAT
AAAIEADLHI AGRFTRIPT
//
