ID V6JI59_STRNV Unreviewed; 3520 AA.
AC V6JI59;
DT 19-FEB-2014, integrated into UniProtKB/TrEMBL.
DT 19-FEB-2014, sequence version 1.
DT 27-MAR-2024, entry version 52.
DE RecName: Full=Carrier domain-containing protein {ECO:0008006|Google:ProtNLM};
GN ORFNames=M877_36030 {ECO:0000313|EMBL:EST19540.1};
OS Streptomyces niveus NCIMB 11891.
OC Bacteria; Actinomycetota; Actinomycetes; Kitasatosporales;
OC Streptomycetaceae; Streptomyces.
OX NCBI_TaxID=1352941 {ECO:0000313|EMBL:EST19540.1, ECO:0000313|Proteomes:UP000017971};
RN [1] {ECO:0000313|EMBL:EST19540.1, ECO:0000313|Proteomes:UP000017971}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=NCIMB 11891 {ECO:0000313|EMBL:EST19540.1,
RC ECO:0000313|Proteomes:UP000017971};
RX PubMed=24407644;
RA Flinspach K., Ruckert C., Kalinowski J., Heide L., Apel A.K.;
RT "Draft Genome Sequence of Streptomyces niveus NCIMB 11891, Producer of the
RT Aminocoumarin Antibiotic Novobiocin.";
RL Genome Announc. 2:e01146-e01113(2014).
CC -!- COFACTOR:
CC Name=pantetheine 4'-phosphate; Xref=ChEBI:CHEBI:47942;
CC Evidence={ECO:0000256|ARBA:ARBA00001957};
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:EST19540.1}.
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DR EMBL; AWQW01000291; EST19540.1; -; Genomic_DNA.
DR PATRIC; fig|1352941.4.peg.7300; -.
DR eggNOG; COG3321; Bacteria.
DR HOGENOM; CLU_000022_35_8_11; -.
DR Proteomes; UP000017971; Chromosome.
DR GO; GO:0004315; F:3-oxoacyl-[acyl-carrier-protein] synthase activity; IEA:InterPro.
DR GO; GO:0031177; F:phosphopantetheine binding; IEA:InterPro.
DR GO; GO:0017000; P:antibiotic biosynthetic process; IEA:UniProtKB-KW.
DR GO; GO:0006633; P:fatty acid biosynthetic process; IEA:InterPro.
DR GO; GO:1901362; P:organic cyclic compound biosynthetic process; IEA:UniProt.
DR CDD; cd08956; KR_3_FAS_SDR_x; 2.
DR CDD; cd00833; PKS; 2.
DR Gene3D; 3.30.70.3290; -; 2.
DR Gene3D; 3.40.47.10; -; 2.
DR Gene3D; 1.10.1200.10; ACP-like; 3.
DR Gene3D; 3.40.366.10; Malonyl-Coenzyme A Acyl Carrier Protein, domain 2; 2.
DR Gene3D; 3.40.50.720; NAD(P)-binding Rossmann-like Domain; 2.
DR Gene3D; 3.10.129.110; Polyketide synthase dehydratase; 2.
DR InterPro; IPR001227; Ac_transferase_dom_sf.
DR InterPro; IPR036736; ACP-like_sf.
DR InterPro; IPR014043; Acyl_transferase.
DR InterPro; IPR016035; Acyl_Trfase/lysoPLipase.
DR InterPro; IPR018201; Ketoacyl_synth_AS.
DR InterPro; IPR014031; Ketoacyl_synth_C.
DR InterPro; IPR014030; Ketoacyl_synth_N.
DR InterPro; IPR016036; Malonyl_transacylase_ACP-bd.
DR InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR InterPro; IPR032821; PKS_assoc.
DR InterPro; IPR020841; PKS_Beta-ketoAc_synthase_dom.
DR InterPro; IPR042104; PKS_dehydratase_sf.
DR InterPro; IPR020807; PKS_DH.
DR InterPro; IPR049551; PKS_DH_C.
DR InterPro; IPR049552; PKS_DH_N.
DR InterPro; IPR013968; PKS_KR.
DR InterPro; IPR020806; PKS_PP-bd.
DR InterPro; IPR009081; PP-bd_ACP.
DR InterPro; IPR006162; Ppantetheine_attach_site.
DR InterPro; IPR016039; Thiolase-like.
DR PANTHER; PTHR43775; FATTY ACID SYNTHASE; 1.
DR PANTHER; PTHR43775:SF51; PHENOLPHTHIOCEROL_PHTHIOCEROL POLYKETIDE SYNTHASE SUBUNIT E; 1.
DR Pfam; PF00698; Acyl_transf_1; 2.
DR Pfam; PF16197; KAsynt_C_assoc; 2.
DR Pfam; PF00109; ketoacyl-synt; 2.
DR Pfam; PF02801; Ketoacyl-synt_C; 2.
DR Pfam; PF08659; KR; 2.
DR Pfam; PF21089; PKS_DH_N; 2.
DR Pfam; PF00550; PP-binding; 3.
DR Pfam; PF14765; PS-DH; 2.
DR SMART; SM00827; PKS_AT; 2.
DR SMART; SM00826; PKS_DH; 2.
DR SMART; SM00822; PKS_KR; 2.
DR SMART; SM00825; PKS_KS; 2.
DR SMART; SM00823; PKS_PP; 3.
DR SMART; SM01294; PKS_PP_betabranch; 2.
DR SUPFAM; SSF47336; ACP-like; 3.
DR SUPFAM; SSF52151; FabD/lysophospholipase-like; 2.
DR SUPFAM; SSF51735; NAD(P)-binding Rossmann-fold domains; 4.
DR SUPFAM; SSF55048; Probable ACP-binding domain of malonyl-CoA ACP transacylase; 2.
DR SUPFAM; SSF53901; Thiolase-like; 2.
DR PROSITE; PS50075; CARRIER; 3.
DR PROSITE; PS00606; KS3_1; 1.
DR PROSITE; PS52004; KS3_2; 2.
DR PROSITE; PS00012; PHOSPHOPANTETHEINE; 1.
PE 4: Predicted;
KW Acyltransferase {ECO:0000256|ARBA:ARBA00023315};
KW Antibiotic biosynthesis {ECO:0000256|ARBA:ARBA00023194};
KW Phosphopantetheine {ECO:0000256|ARBA:ARBA00022450};
KW Phosphoprotein {ECO:0000256|ARBA:ARBA00022553};
KW Transferase {ECO:0000256|ARBA:ARBA00022679}.
FT DOMAIN 1..81
FT /note="Carrier"
FT /evidence="ECO:0000259|PROSITE:PS50075"
FT DOMAIN 103..529
FT /note="Ketosynthase family 3 (KS3)"
FT /evidence="ECO:0000259|PROSITE:PS52004"
FT DOMAIN 1699..1774
FT /note="Carrier"
FT /evidence="ECO:0000259|PROSITE:PS50075"
FT DOMAIN 1793..2218
FT /note="Ketosynthase family 3 (KS3)"
FT /evidence="ECO:0000259|PROSITE:PS52004"
FT DOMAIN 3402..3477
FT /note="Carrier"
FT /evidence="ECO:0000259|PROSITE:PS50075"
FT REGION 1661..1690
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 3520 AA; 366996 MW; 9D0455DB7DAAA4B6 CRC64;
MLELVLAQAA AVLRTADPDA YGEGAIDLAA DRPFLAGGLD SLGLVQLQRR LAAEVGVDLP
VTLAFDHPTP IALAGHLADL LHGTAGADAP DETAAPALPS AFGEPIAIVG IGCRFPGGVS
TPEDLWRIVA DDTHVLTDFP SDRGWDLDRI YNPDPSVTGA SYVRRGGFLP DAADFDADFF
QISPKEALAM DPQQRLLLET SWEALEHAGI DPGRLRGTPS GVFIGVEPHE YGPRTHEAPD
GLDGYVLGGN LPSVVSGRVA YTLGFEGPTL TVDTACSGSL TALHLAVRSL QGGECGLALA
GGVTVISSPG TFTTFSRQRG LAPDGRIKAF AAAADGTSFA EGVGVFVLAR LSDALRDGHP
VLAVIRGTAI NQDGATNGLS APNGLAQQRV IRRALADARL TADEVDAVEA HGTGTTLGDP
IEGQALVAAY GRGRSPEKPL WLGSVKSNIG HTGAAAGAAG IIKMVQAMRH STLPRTLHVD
APTTHVDWSD GTVQLLTEPV PWEAADTPRR AGISSFGASG TNAHVIIEEP PAPVAADGSD
EPPVAERPVP VVLSAQGQDA LRGQAERLLT AVDDASPLDL AYSAATTRAA LRDRATVVAA
DRAELRRALT ALAAGESAPG LLTGTTPATG RTAFLFTGQG SQRLGMGREL VRAFPVFARA
LQDAADHLDL HLDEPLGEVL FAEPGSAQAE LLQQTRYAQA ALFAVETAMF RLLESWGVTP
GLLTGHSIGE IAAAHVAGVM NLADAALLVG ARGTLMQELP AGGAMVAVQA AEAEVAPYLT
EKVGIAAVNG PLAVVLSGET DAVLAVAARF TEEGRKTRRL RVSHAFHSPL MEPMLDDFRR
VAETLTYQPP RIPVVSNLTG EPCAAFDADY WVRHVREPVR FADAMSWLES QGVTTYLELG
PDAVLSAMGR DCLADSDGGA DAAFAALLRD GHDEERQSLT ALGLAHAHGL AVDWDRFFAG
RGAHRTALPT YSFQRKRYWL DAGSSHPGTI GHPMLDSAVS LAGADGVILT GRMSTRAQPW
LADHVIAGVV LVPGTALVEL AVRAGDEAGC AAVEELTLET PLAVTTDAGV EIQVVVGALD
ASGRRSVDIY SRPARSEDNW TRHASGVLTE HGEGATADPA VFAQWPPADA EPIDVDGLYE
RQAAQGYGYG PAFRRVRAAW RRGDDVFAEV ALDEAGGDRF GLHPALLDSS LHAAEGPEDD
GQVRLPFAWR GVELHATGAT AVRVHVVQTA PDEVTVELAD ANGAPVATVR SLVQRPVPIN
GVRPSASGGG SLLRVEWTAV QAPSEPDAAS HEFQLAYVPE SFPGEPADAA RAATLHALTL
IQDALRDDTR LAIVTRGEPY DFTLASPWAL VRSAQAENPG RFVLVGTDHD VPEHELRAAL
ASGEPQLALR DGKVLVPRLA RTPVPEDPRP VAWHPDGTVL ITGGTGGLGG VVARHLVRQH
GVRHLLLTGR RGPDSPGAAE LVADLAALGA HATVAACDVA DRAALATLLE TVPDEHPLTG
VVHSAGVVDD GLAGSLTPEQ VHTVFHGKAD GAWHLHELTR GLPLAAFVLF SSAAGTMEAA
GQGNYAAANA FLDALAAHRA TQGLPATSLA WNLWAGDAGM GARLDEVTLR RAERSGLPAL
DAEENLALLD QALVTDAPTL VPLRVDAPAL RARSEGIPPM LRGLVRPPAR RNTAASAASG
PGGALADRLA GKPDAERERI VLDLVRTQIA AVLGHDSGTA IDPRRAFTEL GFDSLAAIEL
RNALGSATGL RLTSTLIFDH PTPRALVDHV LETVRGAAPV VAAPRATVRA ATDEPIAIVA
MGCRYPGGVT SAEELWRLVA GGTDAITEFP DDRDWHTDDI YDPEPGKHGT TYTREGGFLH
DVAEFDPAFF GISPKEAQAM DPQHRMLLEV AWEALEQGGI DPHSLHGTAA GVFAGVMNHD
WTTRSGAVPE DLAGFTAGGG LGSIASGRIA YTLGLQGPAV TIDTACSSSL VAMHWAMQSL
RQGECTLALA GGVTVMATPE TFVGMSLQSG LAADGRCKAY GAGADGTGWG EGAGLLVLER
LSDARRNGHP VVAVIRGSAI NQDGASNGIA APNGPAQQRV IRQAVASAGL TLADIDAVEG
HGTGTTLGDP IEAQALMATY GQERRDDPLW LGSVKSNLGH TQAAAGVAGV IKMVMAMRHG
VLPRTLHAET PSPHIDWTEG AVELLTEPRD WTADGRPRRA AVSSFGVSGT NAHVIIEQAP
PAGPGEPRGA RPPVVPLTVS GSTPEAMRAQ AARIAAHLRE NGDVDELDAA ATLARGRAAL
EHRAVIVDAD RDGLLAGLDA LAAGTSSAAV VQGLQRGDSR AVLVFPGQGS QWQGMGVELL
EHSPAFAIRL GECAKALEPY VDWNLLDVVH GAPGAPALDA VDVVQPTLWA LMVSLAEAWR
AAGVEPAAVV GHSQGEIAAA CVAGALSLED GARVVALRSR VIRQDLAGRG GMMSVALSAD
RASEYLADWD GRLQLAVVNG PGSVVVCGGP EALDELRARL DTDEVQSRRI PVDYASHSMF
VEEIRDRLLT ELSGLTPRTS SIPFYSTVTA GTLDTAGLDA EYWYTNLRQT VRFEDTTRAL
LADGFETFIE ASPHPGLLTG LDETAESAGV AATLVGTLRR DSGSPRQFVT SLAEAYVRGA
TVDWDTQFAG TGAQHVELPT YPFQRKRYWL HLSEHTGDAV GIGQIPTDHP LLGSAVPVAG
AGGVLLTGRL SLSGQPWLAD HVVGGTVLFP GSGFVELAVR AGDEVGRGRV EELTLEAPLA
LPERGGVAIQ VVVDADLRTV SIHSRPDNAP ADTLWTRHAQ GTLTDAAPEP AHEPAAWPPP
GAEPVDLTGF YEPAADGGLA YGPVFQGLRA AWRSGDEVFA EITLPEQAAA EAQRFGLHPA
ALDAALHATG LLATDAQRVT LPFAWTRVDL HASGAAALRL RMTSLGDDEV ALRLTDTAGR
PVASVESLVL RPVAPGGPIR TGAYDDSLFE LVWAPAAPVP GGTAPRTVVH HCTGGTTAAS
AHAETATTLA VLQSWLESGA DDAVLAVVTR GALSVNGEDV TDLAGAAVWG LVRSAQTENP
GRVVLIDLDA VDDRADHTDA DIDAAVATGE AQIAIRSGTL HRPRLARVTG DLSGTAATVF
GDRPGTVLIT GGTGTLGSLV ARHLVTTHGV TDLLLTSRRG PAAPGAAELD AELTALGARV
EVVACDTADR DALAAVLADR TLTGIVHTAG VLDDGILSSL TPERMAAVMR PKVDAALNLH
ELTAGQDLSA FVMFSSAAGV TGGAGQGNYA AANTFLDGLA AHRRANGLPA QSLGWGLWEE
ASGMTGELAD ADVAGMVRDG VLPIGSDEGL AMLDAAGALD RAFLAPVRLD LSGQSRSDVP
YLMRDLVRGP SRRVVDPAAR AAEPAESLRD RLARLTPARR EQTLLDIVRA QAATTLGFGD
ADEVDADRSF RDMGFDSLAA VRFRNALGEV IGERLPATLV FDHPTSLVLT RHLLGEMAID
VPENEPEPES AEGAADRTAA IQNMSLADLL RTARRSGDPT
//
