ID V6KH12_STRRC Unreviewed; 1117 AA.
AC V6KH12;
DT 19-FEB-2014, integrated into UniProtKB/TrEMBL.
DT 19-FEB-2014, sequence version 1.
DT 27-MAR-2024, entry version 51.
DE SubName: Full=AfsR family transcriptional regulator {ECO:0000313|EMBL:EST28284.1};
GN ORFNames=M878_22930 {ECO:0000313|EMBL:EST28284.1};
OS Streptomyces roseochromogenus subsp. oscitans DS 12.976.
OC Bacteria; Actinomycetota; Actinomycetes; Kitasatosporales;
OC Streptomycetaceae; Streptomyces.
OX NCBI_TaxID=1352936 {ECO:0000313|EMBL:EST28284.1, ECO:0000313|Proteomes:UP000017984};
RN [1] {ECO:0000313|EMBL:EST28284.1, ECO:0000313|Proteomes:UP000017984}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=DS 12.976 {ECO:0000313|EMBL:EST28284.1,
RC ECO:0000313|Proteomes:UP000017984};
RX PubMed=24407645;
RA Ruckert C., Kalinowski J., Heide L., Apel A.K.;
RT "Draft Genome Sequence of Streptomyces roseochromogenes subsp. oscitans DS
RT 12.976, Producer of the Aminocoumarin Antibiotic Clorobiocin.";
RL Genome Announc. 2:e01147-e01113(2014).
CC -!- SIMILARITY: Belongs to the AfsR/DnrI/RedD regulatory family.
CC {ECO:0000256|ARBA:ARBA00005820}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:EST28284.1}.
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DR EMBL; AWQX01000197; EST28284.1; -; Genomic_DNA.
DR AlphaFoldDB; V6KH12; -.
DR STRING; 1352936.M878_22930; -.
DR PATRIC; fig|1352936.5.peg.4780; -.
DR HOGENOM; CLU_004665_1_3_11; -.
DR OrthoDB; 499349at2; -.
DR Proteomes; UP000017984; Chromosome.
DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-UniRule.
DR GO; GO:0000160; P:phosphorelay signal transduction system; IEA:UniProtKB-KW.
DR GO; GO:0006355; P:regulation of DNA-templated transcription; IEA:InterPro.
DR CDD; cd15831; BTAD; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR Gene3D; 1.25.40.10; Tetratricopeptide repeat domain; 2.
DR Gene3D; 1.10.10.10; Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain; 1.
DR InterPro; IPR041664; AAA_16.
DR InterPro; IPR005158; BTAD.
DR InterPro; IPR001867; OmpR/PhoB-type_DNA-bd.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR016032; Sig_transdc_resp-reg_C-effctor.
DR InterPro; IPR011990; TPR-like_helical_dom_sf.
DR InterPro; IPR036388; WH-like_DNA-bd_sf.
DR PANTHER; PTHR47691:SF3; HTH-TYPE TRANSCRIPTIONAL REGULATOR RV0890C-RELATED; 1.
DR PANTHER; PTHR47691; REGULATOR-RELATED; 1.
DR Pfam; PF13191; AAA_16; 1.
DR Pfam; PF03704; BTAD; 1.
DR Pfam; PF00486; Trans_reg_C; 1.
DR SMART; SM01043; BTAD; 1.
DR SMART; SM00862; Trans_reg_C; 1.
DR SUPFAM; SSF46894; C-terminal effector domain of the bipartite response regulators; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR SUPFAM; SSF48452; TPR-like; 2.
DR PROSITE; PS51755; OMPR_PHOB; 1.
PE 3: Inferred from homology;
KW DNA-binding {ECO:0000256|PROSITE-ProRule:PRU01091};
KW Reference proteome {ECO:0000313|Proteomes:UP000017984};
KW Two-component regulatory system {ECO:0000256|ARBA:ARBA00023012}.
FT DOMAIN 1..83
FT /note="OmpR/PhoB-type"
FT /evidence="ECO:0000259|PROSITE:PS51755"
FT DNA_BIND 1..83
FT /note="OmpR/PhoB-type"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU01091"
FT REGION 227..283
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1117 AA; 119836 MW; E4785B7DFDE8A4A8 CRC64;
MTQAADDQGT PIPIGGPRLR TLLTTLALRP SRTTTPETLI DEIWADDPPH DAPAALQALI
GRLRRTLGRH SIASTPGGYR LEATEDDVDL YVFEELVRTG TKALTAGDPA TAHRTLTEAL
ALWHGPALAD LPDRTAATRP EALRREATRA RAAAALDLGR APDVVPELKE LTAAHPLDEP
LHALLIRALR DTGRPADALA AYESARRTLA DTLGTDPGPE LKALHTSLLT QRQPQPQPKS
RPKPDAPRQP DAQSDVEPEP LKPAAPAQPP ERTGNLRPRL TSFVGREPEL EAIRSDLHRA
RLVTLTGPGG SGKTRLAEEA AAGLPQAWLV ELAPLDHPEA VPGAVVSALG LRETVLLTNE
LGTPQADPVA LLIEYCAPRS QLLILDNCEH VIGAAAALAE TLLTHCPGLT ILATSREPLG
VPGESVRPVE PLVPEQAHRL FAERAKAVRP DAGAVLSDTE AVAEICRRLD GLPLAIELAA
ARLRLLTPRQ IADRLDDRFR LLTSGSRTVL PRQQTLRAVV DWSWDLLDER ERTVLREVSV
FAGGWDLAAA EAVCTGPAAD LIGALVDKSL VVAAPDASGG SMRYRMLETI HEYATERAAE
AAGLRAGAER RHRAWVRALV EAAEPRLRSA DQLPWISRLE TELDNIRAAL DRSVRAGDEP
EAGAIVLAIG WFWWLRNHRQ EAVSRVRLVL RLGVALDTLD TPEGPAPGGD LMELVESADP
VGALLAVPDG EAGHPLRELR MDLRMLDLFL TSESATEHLA GDPRAPEYLA CVRAAFAHGG
PRAARLPGIV WPLTAYYLGG AGDLGPDMAA AVANCRVYGG DWEVGVSLMY RTHTMVDSPG
NLRGVDEDLA ELRTLSRRVG DRWMRAQVCS AAGEAAMARG RFGEARGEYE EALRLAYEVG
AYAESPFLMA RLAEIAYRSG DPKAALASLD EAEAAADRYA VPESRAFVLL LRAHIALHDG
EHAAARELYE ATCAVTHGGN PPPQFVAALH SVEALLVAAE SGPAHGLPIV AMALREAVAQ
RCAESITAGL VDIAAGLQAR RGDLAGAVRL FAAADHWRDG NLRPEPERSE ALRVQSGARV
VLSAERYEAE RARGASLDVA DVLRELDATA ARTAERG
//
