ID V6KWL2_STRRC Unreviewed; 306 AA.
AC V6KWL2;
DT 19-FEB-2014, integrated into UniProtKB/TrEMBL.
DT 19-FEB-2014, sequence version 1.
DT 27-MAR-2024, entry version 40.
DE RecName: Full=3-alpha,7-alpha, 12-alpha-trihydroxy-5-beta-cholest-24-enoyl-CoA hydratase {ECO:0008006|Google:ProtNLM};
GN ORFNames=M878_01160 {ECO:0000313|EMBL:EST36522.1};
OS Streptomyces roseochromogenus subsp. oscitans DS 12.976.
OC Bacteria; Actinomycetota; Actinomycetes; Kitasatosporales;
OC Streptomycetaceae; Streptomyces.
OX NCBI_TaxID=1352936 {ECO:0000313|EMBL:EST36522.1, ECO:0000313|Proteomes:UP000017984};
RN [1] {ECO:0000313|EMBL:EST36522.1, ECO:0000313|Proteomes:UP000017984}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=DS 12.976 {ECO:0000313|EMBL:EST36522.1,
RC ECO:0000313|Proteomes:UP000017984};
RX PubMed=24407645;
RA Ruckert C., Kalinowski J., Heide L., Apel A.K.;
RT "Draft Genome Sequence of Streptomyces roseochromogenes subsp. oscitans DS
RT 12.976, Producer of the Aminocoumarin Antibiotic Clorobiocin.";
RL Genome Announc. 2:e01147-e01113(2014).
CC -!- SIMILARITY: Belongs to the enoyl-CoA hydratase/isomerase family.
CC {ECO:0000256|ARBA:ARBA00005254}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:EST36522.1}.
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DR EMBL; AWQX01000007; EST36522.1; -; Genomic_DNA.
DR RefSeq; WP_023544268.1; NZ_CM002285.1.
DR AlphaFoldDB; V6KWL2; -.
DR STRING; 1352936.M878_01160; -.
DR PATRIC; fig|1352936.5.peg.272; -.
DR HOGENOM; CLU_040078_1_1_11; -.
DR OrthoDB; 5522043at2; -.
DR Proteomes; UP000017984; Chromosome.
DR GO; GO:0003824; F:catalytic activity; IEA:UniProtKB-KW.
DR GO; GO:0008152; P:metabolic process; IEA:UniProtKB-KW.
DR CDD; cd03448; HDE_HSD; 1.
DR Gene3D; 3.10.129.10; Hotdog Thioesterase; 1.
DR InterPro; IPR029069; HotDog_dom_sf.
DR InterPro; IPR039569; MaoC-like_dehydrat_N.
DR InterPro; IPR002539; MaoC-like_dom.
DR PANTHER; PTHR13078:SF56; PEROXISOMAL MULTIFUNCTIONAL ENZYME TYPE 2; 1.
DR PANTHER; PTHR13078; PEROXISOMAL MULTIFUNCTIONAL ENZYME TYPE 2-RELATED; 1.
DR Pfam; PF13452; MaoC_dehydrat_N; 1.
DR Pfam; PF01575; MaoC_dehydratas; 1.
DR SUPFAM; SSF54637; Thioesterase/thiol ester dehydrase-isomerase; 2.
PE 3: Inferred from homology;
KW Reference proteome {ECO:0000313|Proteomes:UP000017984}.
FT DOMAIN 54..141
FT /note="N-terminal of MaoC-like dehydratase"
FT /evidence="ECO:0000259|Pfam:PF13452"
FT DOMAIN 166..263
FT /note="MaoC-like"
FT /evidence="ECO:0000259|Pfam:PF01575"
SQ SEQUENCE 306 AA; 32659 MW; 35EBB0E34CB6F7E1 CRC64;
MPIDVEKVTS APPVRAAAVW DDREVRLYHL ALGAGVPETD PGELRYAFEG HEQGLQVLPT
FGVVAGGTGG VGFQVFEMPG VDIDLAAVLH GGQEIAVHRP LPAAARATTV TRVPAVYDKG
KAAVIVQEAT LVGEDGEPLL TQRNQIYVHG EGGFGGDRGP SERFPAPDRE PDLVLEVPTL
RQQALLYRLA GDWNPLHADP ATARRAGYDR PILHGLCSFG MAVKAVTDRL LGGDATRITG
CRTRFAGVFF PGETLRLRIW AASEEGDGNG GHDTYQLTAT AAERGDAPVL TDARVTARTT
RRGSTR
//
