ID V6L5X7_STRRC Unreviewed; 794 AA.
AC V6L5X7;
DT 19-FEB-2014, integrated into UniProtKB/TrEMBL.
DT 19-FEB-2014, sequence version 1.
DT 24-JAN-2024, entry version 32.
DE RecName: Full=Probable phosphoketolase {ECO:0000256|HAMAP-Rule:MF_01403};
DE EC=4.1.2.- {ECO:0000256|HAMAP-Rule:MF_01403};
GN ORFNames=M878_01705 {ECO:0000313|EMBL:EST36629.1};
OS Streptomyces roseochromogenus subsp. oscitans DS 12.976.
OC Bacteria; Actinomycetota; Actinomycetes; Kitasatosporales;
OC Streptomycetaceae; Streptomyces.
OX NCBI_TaxID=1352936 {ECO:0000313|EMBL:EST36629.1, ECO:0000313|Proteomes:UP000017984};
RN [1] {ECO:0000313|EMBL:EST36629.1, ECO:0000313|Proteomes:UP000017984}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=DS 12.976 {ECO:0000313|EMBL:EST36629.1,
RC ECO:0000313|Proteomes:UP000017984};
RX PubMed=24407645;
RA Ruckert C., Kalinowski J., Heide L., Apel A.K.;
RT "Draft Genome Sequence of Streptomyces roseochromogenes subsp. oscitans DS
RT 12.976, Producer of the Aminocoumarin Antibiotic Clorobiocin.";
RL Genome Announc. 2:e01147-e01113(2014).
CC -!- COFACTOR:
CC Name=thiamine diphosphate; Xref=ChEBI:CHEBI:58937;
CC Evidence={ECO:0000256|ARBA:ARBA00001964,
CC ECO:0000256|HAMAP-Rule:MF_01403};
CC -!- SIMILARITY: Belongs to the XFP family. {ECO:0000256|ARBA:ARBA00005623,
CC ECO:0000256|HAMAP-Rule:MF_01403}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:EST36629.1}.
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DR EMBL; AWQX01000007; EST36629.1; -; Genomic_DNA.
DR RefSeq; WP_023544376.1; NZ_CM002285.1.
DR AlphaFoldDB; V6L5X7; -.
DR STRING; 1352936.M878_01705; -.
DR PATRIC; fig|1352936.5.peg.384; -.
DR HOGENOM; CLU_013954_2_0_11; -.
DR OrthoDB; 9768449at2; -.
DR Proteomes; UP000017984; Chromosome.
DR GO; GO:0016832; F:aldehyde-lyase activity; IEA:UniProtKB-UniRule.
DR GO; GO:0000287; F:magnesium ion binding; IEA:UniProt.
DR GO; GO:0005975; P:carbohydrate metabolic process; IEA:InterPro.
DR CDD; cd02011; TPP_PK; 1.
DR Gene3D; 3.40.50.920; -; 1.
DR Gene3D; 3.40.50.970; -; 2.
DR HAMAP; MF_01403; Phosphoketolase; 1.
DR InterPro; IPR023962; Phosphoketolase.
DR InterPro; IPR029061; THDP-binding.
DR InterPro; IPR009014; Transketo_C/PFOR_II.
DR InterPro; IPR005593; Xul5P/Fru6P_PKetolase.
DR InterPro; IPR018969; Xul5P/Fru6P_PKetolase_C.
DR InterPro; IPR019790; Xul5P/Fru6P_PKetolase_CS.
DR InterPro; IPR018970; Xul5P/Fru6P_PKetolase_N.
DR InterPro; IPR019789; Xul5P/Fru6P_PKetolase_ThDP_BS.
DR PANTHER; PTHR31273; PHOSPHOKETOLASE-RELATED; 1.
DR PANTHER; PTHR31273:SF0; PHOSPHOKETOLASE-RELATED; 1.
DR Pfam; PF03894; XFP; 1.
DR Pfam; PF09363; XFP_C; 1.
DR Pfam; PF09364; XFP_N; 1.
DR PIRSF; PIRSF017245; Phosphoketolase; 1.
DR SUPFAM; SSF52518; Thiamin diphosphate-binding fold (THDP-binding); 2.
DR PROSITE; PS60002; PHOSPHOKETOLASE_1; 1.
DR PROSITE; PS60003; PHOSPHOKETOLASE_2; 1.
PE 3: Inferred from homology;
KW Lyase {ECO:0000256|ARBA:ARBA00023239, ECO:0000256|HAMAP-Rule:MF_01403};
KW Reference proteome {ECO:0000313|Proteomes:UP000017984};
KW Thiamine pyrophosphate {ECO:0000256|ARBA:ARBA00023052, ECO:0000256|HAMAP-
KW Rule:MF_01403}.
FT DOMAIN 12..373
FT /note="Xylulose 5-phosphate/Fructose 6-phosphate
FT phosphoketolase N-terminal"
FT /evidence="ECO:0000259|Pfam:PF09364"
FT DOMAIN 590..792
FT /note="Xylulose 5-phosphate/Fructose 6-phosphate
FT phosphoketolase C-terminal"
FT /evidence="ECO:0000259|Pfam:PF09363"
SQ SEQUENCE 794 AA; 88285 MW; C4BCB085B702BA44 CRC64;
MSVDQQQAPT QLTENELRSL DAHWRAANYL SVGQIYLMAN PLVTEPLRPE HVKPRLLGHW
GTSPGLNLVY THLNRVIKTR DLDALCVWGP GHGGPAVLAN SWLEGSYSQT YPDVTRDAAG
MARLFKQFSF PGGVPSHVAP ETPGSIHEGG ELGYSLSHAY GAALDNPGLL VACVIGDGEA
ETGPLAASWH SNKFLDPVHD GAVLPILHLN GYKIANPTVL SRLPESELDE LLRGYGHDLI
HVTGDDPAAV HGAMARAMDT AVDRIAAIQR AAREDGVTDR PRWPVIVLRT PKGWTGPAEV
DGLPVEGTWR AHQVPLAAVR DNPEHLRQLE QWLRSYRPEE LFDEQGAPRP DVLACIPHGA
RRLGATPYAN GGLLLRELPL SPLEKYAVEV DKPGATLHEP TRVLGDMLQD VMAATADRRD
FRLVGPDETA SNRLQAVYAA SGKAWQAETL PVDEHLDRHG RVMEILSEHT CQGWLEGYLL
TGRHGLFSCY EAFVHIVDSM VNQHIKWLRT TRRLPWRAPI ASLNYLLTSH VWRQDHNGFS
HQDPGFVDHI LNKSPEAVRV YLPPDANTLL SVADHILRSR DYVNVVVAGK QPCFDWLSMG
EAKVHCARGA GIWEWAGTED GSREPDVVLA CAGDVPTQEV LAAAQLLRRH LPELAVRVVN
VVDIARLLPA EEHPHGMTDF EYDGLFTPDK PVLFAYHGYP WLIHRLAYRR TGHRNLHVRG
YKEIGTTTTP FDMVVSNDLD RYRLVMDVID RVPGLAVRAA AVRQAMEDVR QRHHVWIREH
GMDLPEVADW TWDG
//
