ID   V6LSX1_9EUKA            Unreviewed;       863 AA.
AC   V6LSX1;
DT   19-FEB-2014, integrated into UniProtKB/TrEMBL.
DT   19-FEB-2014, sequence version 1.
DT   08-NOV-2023, entry version 40.
DE   SubName: Full=Ubiquitin carboxyl-terminal hydrolase family protein {ECO:0000313|EMBL:EST43894.1};
GN   ORFNames=SS50377_16194 {ECO:0000313|EMBL:EST43894.1}, SS50377_21113
GN   {ECO:0000313|EMBL:KAH0577759.1};
OS   Spironucleus salmonicida.
OC   Eukaryota; Metamonada; Diplomonadida; Hexamitidae; Hexamitinae;
OC   Spironucleus.
OX   NCBI_TaxID=348837 {ECO:0000313|EMBL:EST43894.1};
RN   [1] {ECO:0000313|EMBL:KAH0577759.1}
RP   NUCLEOTIDE SEQUENCE.
RC   STRAIN=ATCC 50377 {ECO:0000313|EMBL:KAH0577759.1};
RX   PubMed=24516394;
RA   Xu F., Jerlstrom-Hultqvist J., Einarsson E., Astvaldsson A., Svard S.G.,
RA   Andersson J.O.;
RT   "The Genome of Spironucleus salmonicida Highlights a Fish Pathogen Adapted
RT   to Fluctuating Environments.";
RL   PLoS Genet. 10:E1004053-E1004053(2014).
RN   [2] {ECO:0000313|EMBL:EST43894.1}
RP   NUCLEOTIDE SEQUENCE.
RA   Xu F., Jerlstrom-Hultqvist J., Einarsson E., Astvaldsson A., Svard S.G.,
RA   Andersson J.O.;
RT   "The Genome of Spironucleus salmonicida Highlights a Fish Pathogen Adapted
RT   to Fluctuating Environments.";
RL   PLoS Genet. 0:0-0(2014).
RN   [3] {ECO:0000313|EMBL:KAH0577759.1}
RP   NUCLEOTIDE SEQUENCE.
RC   STRAIN=ATCC 50377 {ECO:0000313|EMBL:KAH0577759.1};
RA   Xu F., Kurt Z., Jimenez-Gonzalez A., Astvaldsson A., Andersson J.O.,
RA   Svard S.G.;
RT   "New Spironucleus salmonicida genome in near-complete chromosomes.";
RL   Submitted (DEC-2020) to the EMBL/GenBank/DDBJ databases.
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DR   EMBL; KI546130; EST43894.1; -; Genomic_DNA.
DR   EMBL; AUWU02000001; KAH0577759.1; -; Genomic_DNA.
DR   AlphaFoldDB; V6LSX1; -.
DR   EnsemblProtists; EST43894; EST43894; SS50377_16194.
DR   VEuPathDB; GiardiaDB:SS50377_21113; -.
DR   OrthoDB; 227085at2759; -.
DR   Proteomes; UP000018208; Unassembled WGS sequence.
DR   GO; GO:0004843; F:cysteine-type deubiquitinase activity; IEA:InterPro.
DR   GO; GO:0008270; F:zinc ion binding; IEA:InterPro.
DR   CDD; cd02257; Peptidase_C19; 1.
DR   Gene3D; 3.90.70.10; Cysteine proteinases; 1.
DR   Gene3D; 3.30.40.10; Zinc/RING finger domain, C3HC4 (zinc finger); 1.
DR   InterPro; IPR038765; Papain-like_cys_pep_sf.
DR   InterPro; IPR001394; Peptidase_C19_UCH.
DR   InterPro; IPR028889; USP_dom.
DR   InterPro; IPR013083; Znf_RING/FYVE/PHD.
DR   InterPro; IPR001607; Znf_UBP.
DR   PANTHER; PTHR21646; UBIQUITIN CARBOXYL-TERMINAL HYDROLASE; 1.
DR   Pfam; PF00443; UCH; 1.
DR   Pfam; PF02148; zf-UBP; 1.
DR   SMART; SM00290; ZnF_UBP; 1.
DR   SUPFAM; SSF54001; Cysteine proteinases; 1.
DR   SUPFAM; SSF57850; RING/U-box; 1.
DR   PROSITE; PS50235; USP_3; 1.
DR   PROSITE; PS50271; ZF_UBP; 1.
PE   4: Predicted;
KW   Hydrolase {ECO:0000313|EMBL:EST43894.1};
KW   Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW   Reference proteome {ECO:0000313|Proteomes:UP000018208};
KW   Zinc {ECO:0000256|ARBA:ARBA00022833};
KW   Zinc-finger {ECO:0000256|ARBA:ARBA00022771, ECO:0000256|PROSITE-
KW   ProRule:PRU00502}.
FT   DOMAIN          8..123
FT                   /note="UBP-type"
FT                   /evidence="ECO:0000259|PROSITE:PS50271"
FT   DOMAIN          156..630
FT                   /note="USP"
FT                   /evidence="ECO:0000259|PROSITE:PS50235"
SQ   SEQUENCE   863 AA;  99637 MW;  C4652C1185FA3466 CRC64;
     MDERVTNLQC SHSPKTYGDV RDLITKNCAQ LFNPDLKCSG SNTSTEKCDR GVDKLWICLD
     CGFVACGHYD NRHSTDHYQE KAHPLFLNLK EYRIWCFSCN VFVSVVKFPD FVARTYRDLQ
     RKKDSTSQPL ASSKIVDSKQ IQQKPQSLDL KTCGQVPIVN NHSTCYASAV LQALAHLSYF
     NRWFWALAPY IQQGTFNTEY EGLEDMVTTH FCQMMQVLQL PDKINQIQCQ FEAQKTHLQP
     FYRALQAYKK VFVGDQQQDA QEFVLFLFDC IRSSLQRKFP IGVLKQQTQY NAKPQLIHFT
     QQQIQSKHRD IVSDCFEGQQ STCSVYQCQY CKKESKTYTV EPFSTLSLHV TKNQVALEQS
     FQTYISPQTM ESKCQNCQNT SHIIQTQKIL YPPPILCLHF MCFEADEKEK IKTNLQNLTN
     LNIFNYLSEL RPGMPEFNED DIQYLYKSLL AQKFTYQIVE QFYLKSQNKQ FNDQAFNQTI
     EPLLAYIICL PDSQSIAIKL AQQLKVLKAQ PPKLDSEQKT KYILECIANE YYEIAKFGTS
     KTDFLKDLLQ NLQSCKIFKQ IKVWSVDELS AGCSEYELQC AILHTGNLAS GHYTTVCKKQ
     NEWIQFDDAN IKSIVESAIK DPYLLFYQKK KSLAQEILTT DIYQQILNSL NSQPCAKICQ
     DLYDQFFRHA ISYSYSFGSI IKFQLTDKCI SGEWLYRLHQ LPWPRANQFA PLDPTLHQYA
     IQPAMVPSKV PINGFLWQLI EAVFGECGEL VVEKGENVGA QQLFDRICCN SIGKPVFALS
     RTFVKELSEH AFYDAQEPGF ANLDLIRTGA PLSRFSLREG LVEGTDFVVV GRQEWMEIQT
     QYGGLEIQLW QRNDIYGLPE EVD
//