ID V6M389_9BACL Unreviewed; 797 AA.
AC V6M389;
DT 19-FEB-2014, integrated into UniProtKB/TrEMBL.
DT 19-FEB-2014, sequence version 1.
DT 24-JAN-2024, entry version 28.
DE SubName: Full=Penicillin-binding protein {ECO:0000313|EMBL:EST52812.1};
GN ORFNames=T458_17855 {ECO:0000313|EMBL:EST52812.1};
OS Brevibacillus panacihumi W25.
OC Bacteria; Bacillota; Bacilli; Bacillales; Paenibacillaceae; Brevibacillus.
OX NCBI_TaxID=1408254 {ECO:0000313|EMBL:EST52812.1, ECO:0000313|Proteomes:UP000017973};
RN [1] {ECO:0000313|EMBL:EST52812.1, ECO:0000313|Proteomes:UP000017973}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=W25 {ECO:0000313|EMBL:EST52812.1,
RC ECO:0000313|Proteomes:UP000017973};
RX PubMed=24459276;
RA Wang X., Jin D., Zhou L., Wu L., An W., Chen Y., Zhao L.;
RT "Draft Genome Sequence of Brevibacillus panacihumi Strain W25, a
RT Halotolerant Hydrocarbon-Degrading Bacterium.";
RL Genome Announc. 2:e01215-13(2014).
CC -!- SIMILARITY: Belongs to the transpeptidase family.
CC {ECO:0000256|ARBA:ARBA00007171}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:EST52812.1}.
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DR EMBL; AYJU01000017; EST52812.1; -; Genomic_DNA.
DR RefSeq; WP_023557423.1; NZ_KI629785.1.
DR AlphaFoldDB; V6M389; -.
DR STRING; 1408254.T458_17855; -.
DR PATRIC; fig|1408254.3.peg.3521; -.
DR eggNOG; COG0768; Bacteria.
DR eggNOG; COG2815; Bacteria.
DR HOGENOM; CLU_009289_6_0_9; -.
DR OrthoDB; 9804124at2; -.
DR Proteomes; UP000017973; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0008658; F:penicillin binding; IEA:InterPro.
DR CDD; cd06576; PASTA_Pbp2x-like_1; 1.
DR CDD; cd06575; PASTA_Pbp2x-like_2; 1.
DR Gene3D; 3.30.450.330; -; 1.
DR Gene3D; 3.30.70.2110; -; 1.
DR Gene3D; 3.40.710.10; DD-peptidase/beta-lactamase superfamily; 1.
DR Gene3D; 3.90.1310.10; Penicillin-binding protein 2a (Domain 2); 1.
DR InterPro; IPR012338; Beta-lactam/transpept-like.
DR InterPro; IPR005543; PASTA_dom.
DR InterPro; IPR005311; PBP_dimer.
DR InterPro; IPR036138; PBP_dimer_sf.
DR InterPro; IPR001460; PCN-bd_Tpept.
DR PANTHER; PTHR30627; PEPTIDOGLYCAN D,D-TRANSPEPTIDASE; 1.
DR PANTHER; PTHR30627:SF1; PEPTIDOGLYCAN D,D-TRANSPEPTIDASE FTSI; 1.
DR Pfam; PF03793; PASTA; 2.
DR Pfam; PF03717; PBP_dimer; 1.
DR Pfam; PF00905; Transpeptidase; 1.
DR SMART; SM00740; PASTA; 2.
DR SUPFAM; SSF56601; beta-lactamase/transpeptidase-like; 1.
DR SUPFAM; SSF56519; Penicillin binding protein dimerisation domain; 1.
DR SUPFAM; SSF54184; Penicillin-binding protein 2x (pbp-2x), c-terminal domain; 2.
DR PROSITE; PS51178; PASTA; 2.
PE 3: Inferred from homology;
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000017973};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT TRANSMEM 12..31
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 617..674
FT /note="PASTA"
FT /evidence="ECO:0000259|PROSITE:PS51178"
FT DOMAIN 675..734
FT /note="PASTA"
FT /evidence="ECO:0000259|PROSITE:PS51178"
FT REGION 735..797
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 755..776
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 783..797
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 797 AA; 87922 MW; 3BDB581112C7F89E CRC64;
METKRRVNWR ILLFALCVII GFSSLSMRLW WLQTVEAAKI MDYARSQWDW EKTLKPKRGA
IMDRNGEILA YEGKAYTVNA RLKPMNEKDQ DYVKDPYYTA TTLSRILNAP MDYLLKRLTT
SQSNVIELGS WGQKITEEQK KLIEEAQYPK LPSGEQVKTN QLPGIYLTEA TRRFYPNNSF
AAHVLGYIDL YDNPKMGLEL QLDEELRGEK GEMAIMTDGA GYQLPDGEHK YKPAEDGKNV
YLTIDRQIQD YVEQALDVAE KEFKPKGLMV VVSDPQTGEI LAMGNRPQFN PNTYYKGITN
FTNHAVTSMF EPGSTFKIIT LAAAIEEGMF NPNEEYQSGT YTIKGQTPIR DHNNGRGWGK
ISFLKGVQRS SNVVFVKLAY ERLKLEKLKA YFEKFGIGSL TGIELPYEKK GNIANLENPR
SPRDWAVTSF GQGVTVTAIQ QIAAVGAIAN GGELLKPHII KEMRDPHTGA VVHRTGREVV
RRVVSTATAK QTRDILETVV EDPDGTGKAY RIPGYSVAGK TGTAQKYEGN KILEGHYIAS
FIGFAPKDNP RLLVYVVVDD PNTSEYTTYS SKIVAPIFKS VMERSLQYLQ QQPDLQSASG
GDKKQAAAQQ TALPPVKELT LPKFIDMATT TAQLRAKQDE LEVTIVGTGT KIVEQYPAPF
SKVVSGQKIT LITDRVEGTQ MPDLTGKSLR DVMEFASILH MNVNATGVGF VDSQSIKAGT
ALKGGETLLV TLKSESEPAP PAPVPDVQAG QDGAESPDDQ GSQETSGASE GQSEEADASG
DTNKPEEGNT GQTSASP
//
