ID V6TC45_GIAIN Unreviewed; 822 AA.
AC V6TC45;
DT 19-FEB-2014, integrated into UniProtKB/TrEMBL.
DT 19-FEB-2014, sequence version 1.
DT 27-MAR-2024, entry version 34.
DE SubName: Full=Serine/threonine protein kinase {ECO:0000313|EMBL:ESU36436.1};
DE Flags: Fragment;
GN ORFNames=DHA2_151940 {ECO:0000313|EMBL:ESU36436.1};
OS Giardia intestinalis (Giardia lamblia).
OC Eukaryota; Metamonada; Diplomonadida; Hexamitidae; Giardiinae; Giardia.
OX NCBI_TaxID=5741 {ECO:0000313|EMBL:ESU36436.1, ECO:0000313|Proteomes:UP000018320};
RN [1] {ECO:0000313|Proteomes:UP000018320}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=DH {ECO:0000313|Proteomes:UP000018320};
RA Adam R., Dahlstrom E., Martens C., Bruno D., Barbian K., Porcella S.F.,
RA Nash T.;
RT "Genome sequencing of Giardia lamblia Genotypes A2 and B isolates (DH and
RT GS) and comparative analysis with the genomes of Genotypes A1 and E (WB and
RT Pig).";
RL Submitted (FEB-2012) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|EMBL:ESU36436.1, ECO:0000313|Proteomes:UP000018320}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=DH {ECO:0000313|EMBL:ESU36436.1,
RC ECO:0000313|Proteomes:UP000018320};
RX PubMed=24307482; DOI=10.1093/gbe/evt197;
RA Adam R.D., Dahlstrom E.W., Martens C.A., Bruno D.P., Barbian K.D.,
RA Ricklefs S.M., Hernandez M.M., Narla N.P., Patel R.B., Porcella S.F.,
RA Nash T.E.;
RT "Genome sequencing of Giardia lamblia genotypes A2 and B isolates (DH and
RT GS) and comparative analysis with the genomes of genotypes A1 and E (WB and
RT Pig).";
RL Genome Biol. Evol. 5:2498-2511(2013).
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:ESU36436.1}.
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DR EMBL; AHGT01000047; ESU36436.1; -; Genomic_DNA.
DR AlphaFoldDB; V6TC45; -.
DR EnsemblProtists; ESU36436; ESU36436; DHA2_151940.
DR VEuPathDB; GiardiaDB:DHA2_151940; -.
DR VEuPathDB; GiardiaDB:GL50581_4066; -.
DR VEuPathDB; GiardiaDB:GL50581_4360; -.
DR VEuPathDB; GiardiaDB:GL50803_0061490; -.
DR VEuPathDB; GiardiaDB:QR46_1159; -.
DR Proteomes; UP000018320; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0005524; F:ATP binding; IEA:InterPro.
DR GO; GO:0004674; F:protein serine/threonine kinase activity; IEA:UniProtKB-KW.
DR GO; GO:0016310; P:phosphorylation; IEA:UniProtKB-KW.
DR Gene3D; 1.25.40.20; Ankyrin repeat-containing domain; 4.
DR Gene3D; 1.10.510.10; Transferase(Phosphotransferase) domain 1; 1.
DR InterPro; IPR002110; Ankyrin_rpt.
DR InterPro; IPR036770; Ankyrin_rpt-contain_sf.
DR InterPro; IPR011009; Kinase-like_dom_sf.
DR InterPro; IPR000719; Prot_kinase_dom.
DR InterPro; IPR008266; Tyr_kinase_AS.
DR PANTHER; PTHR24120:SF4; ANKYRIN REPEAT AND SOCS BOX PROTEIN 12; 1.
DR PANTHER; PTHR24120; GH07239P; 1.
DR Pfam; PF00023; Ank; 2.
DR Pfam; PF12796; Ank_2; 2.
DR Pfam; PF00069; Pkinase; 1.
DR SMART; SM00248; ANK; 9.
DR SUPFAM; SSF48403; Ankyrin repeat; 1.
DR SUPFAM; SSF56112; Protein kinase-like (PK-like); 1.
DR PROSITE; PS50297; ANK_REP_REGION; 1.
DR PROSITE; PS50088; ANK_REPEAT; 2.
DR PROSITE; PS50011; PROTEIN_KINASE_DOM; 1.
DR PROSITE; PS00109; PROTEIN_KINASE_TYR; 1.
PE 4: Predicted;
KW ANK repeat {ECO:0000256|PROSITE-ProRule:PRU00023};
KW Coiled coil {ECO:0000256|SAM:Coils}; Kinase {ECO:0000313|EMBL:ESU36436.1};
KW Membrane {ECO:0000256|SAM:Phobius};
KW Serine/threonine-protein kinase {ECO:0000313|EMBL:ESU36436.1};
KW Transferase {ECO:0000313|EMBL:ESU36436.1};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT TRANSMEM 191..212
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 99..352
FT /note="Protein kinase"
FT /evidence="ECO:0000259|PROSITE:PS50011"
FT REPEAT 545..577
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT REPEAT 725..757
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT REGION 1..24
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 373..446
FT /evidence="ECO:0000256|SAM:Coils"
FT NON_TER 1
FT /evidence="ECO:0000313|EMBL:ESU36436.1"
SQ SEQUENCE 822 AA; 90571 MW; 4FA4769A792E68E1 CRC64;
VDHTPTRFRR GQGEQVSLPP VSTGTPVGET VAQVVFSSLM QKPFVSIGPL QICRHKPLWK
RIVSKTVDYQ NNTRMDTASS EPAITAFSVP PFTPREVHER LGDVLNENTM GTVYSLEGYP
SLAVQEILLD GLDKGDLDAI KTRLTVILTL SHPGVLKHHQ VVEDEGLIYV VTDRQDKTLE
RLLAEHKRRK IFVPIAVILS VMKQVAAALA YLHGLSGVGA NGLVHCDLRP ANVLISADGE
RFIVADFGLC RNTLWSESTI AGMAVYMAPE VLLHNEASPA SDVWSLGAIL YELTTLRRLD
FLKGKEPAEV FVDGWKPNLS GITDGFIKSI LERIFVLEPE RRLTARELHD TLTAADIPVG
ELGAQYAMLR YECGSLKAAL NNAKARIATL EAALDARSAE MVSQSTETAS LKDALENQGK
EHLAMIKALE NRFTQSNSEM NRADSQINLS ALPRLIRAAH TNDMETVQML ANKRNYIGQR
DEQEMTALMH AAQQGHVGPV ELLVRKERGL KDKSGWTALI HATHNNHPEV VKIIAPHEHG
KRNKNGRTAL MIAAQKGYAK VVSVLAPYEE DLTDRYNKTA LILAAEARHE DVVEVLDPTD
DRGVTALMRA VGRGDMATAK ALVALQRGRV AHGETALMQA VTYDNINGIK LLLPHESGMH
DRYGATALMK AAYKGYLEAV KLLIKKESGM KDNYNRTALM EAATRNHLEI VIMLIEYEAC
MRDSSGETAL MKAASNGHLE VVELLIEYEA GKNDDSGETA LIKAALGGYP KVVELLFESE
GYLIDKSDKS FFGKLEAKGY FEIVSFLRDS SRTSSTDDYS YS
//
