ID V6TH16_GIAIN Unreviewed; 1067 AA.
AC V6TH16;
DT 19-FEB-2014, integrated into UniProtKB/TrEMBL.
DT 19-FEB-2014, sequence version 1.
DT 13-SEP-2023, entry version 26.
DE RecName: Full=CDC45-like protein {ECO:0008006|Google:ProtNLM};
GN ORFNames=DHA2_152689 {ECO:0000313|EMBL:ESU37642.1};
OS Giardia intestinalis (Giardia lamblia).
OC Eukaryota; Metamonada; Diplomonadida; Hexamitidae; Giardiinae; Giardia.
OX NCBI_TaxID=5741 {ECO:0000313|EMBL:ESU37642.1, ECO:0000313|Proteomes:UP000018320};
RN [1] {ECO:0000313|Proteomes:UP000018320}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=DH {ECO:0000313|Proteomes:UP000018320};
RA Adam R., Dahlstrom E., Martens C., Bruno D., Barbian K., Porcella S.F.,
RA Nash T.;
RT "Genome sequencing of Giardia lamblia Genotypes A2 and B isolates (DH and
RT GS) and comparative analysis with the genomes of Genotypes A1 and E (WB and
RT Pig).";
RL Submitted (FEB-2012) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|EMBL:ESU37642.1, ECO:0000313|Proteomes:UP000018320}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=DH {ECO:0000313|EMBL:ESU37642.1,
RC ECO:0000313|Proteomes:UP000018320};
RX PubMed=24307482; DOI=10.1093/gbe/evt197;
RA Adam R.D., Dahlstrom E.W., Martens C.A., Bruno D.P., Barbian K.D.,
RA Ricklefs S.M., Hernandez M.M., Narla N.P., Patel R.B., Porcella S.F.,
RA Nash T.E.;
RT "Genome sequencing of Giardia lamblia genotypes A2 and B isolates (DH and
RT GS) and comparative analysis with the genomes of genotypes A1 and E (WB and
RT Pig).";
RL Genome Biol. Evol. 5:2498-2511(2013).
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
CC -!- SIMILARITY: Belongs to the CDC45 family.
CC {ECO:0000256|ARBA:ARBA00010727}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:ESU37642.1}.
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DR EMBL; AHGT01000024; ESU37642.1; -; Genomic_DNA.
DR AlphaFoldDB; V6TH16; -.
DR EnsemblProtists; ESU37642; ESU37642; DHA2_152689.
DR VEuPathDB; GiardiaDB:DHA2_152689; -.
DR VEuPathDB; GiardiaDB:GL50581_4155; -.
DR VEuPathDB; GiardiaDB:GL50803_00137731; -.
DR VEuPathDB; GiardiaDB:QR46_1520; -.
DR Proteomes; UP000018320; Unassembled WGS sequence.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0007049; P:cell cycle; IEA:UniProtKB-KW.
DR GO; GO:0006270; P:DNA replication initiation; IEA:InterPro.
DR InterPro; IPR003874; CDC45.
DR PANTHER; PTHR10507; CDC45-RELATED PROTEIN; 1.
DR PANTHER; PTHR10507:SF0; CELL DIVISION CONTROL PROTEIN 45 HOMOLOG; 1.
DR Pfam; PF02724; CDC45; 1.
PE 3: Inferred from homology;
KW Cell cycle {ECO:0000256|ARBA:ARBA00023306};
KW DNA replication {ECO:0000256|ARBA:ARBA00022705};
KW Nucleus {ECO:0000256|ARBA:ARBA00023242}.
FT REGION 183..307
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1026..1067
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 183..223
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 281..304
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1026..1047
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1067 AA; 119557 MW; 012DA6043F8C2DB8 CRC64;
MSWPPKSPSQ RQALVGFCLL ESLLERHLML LDSFQFHAHM KGFPNVAVAF RLDVDALASV
ALLRLFFRMH HIPFSVYPTY TDFHLLSLLE TLSQMTSLKA EPNDRVVMLI NAGATQDLTQ
YESLRIYVID YFRPASLANV ASQHVFLFDE GLILGSLLLS FFPQKATRIL HEAMLSIRLN
KAREGENAPH SQKDEEDSTN TIDTKSYRRV RREDKEREQP DHVYPAQDQS LSDDQDTETS
ESTDAPQHHP FDGSDTDFIN VPAAPSQSGK LGLLLDDPID QDISPHGEPE YSDSVNKEST
EESVHSSLQD GAQLSFVSDD THLTDVSMGA THRQVDVLLK EAELHSHESR RHLSTSFNAQ
AHPFKYSDMT RQSESQGDSV QDDRQDAVAA AFALLQEKAV STSSITELAT LQVLYCKLSA
EDFTHIYRVL SSTISHPSSA QVAMTAEYMK LRAIASPSAI LLYNILSEEA KTGLFMNRSL
MVSIQWHAMT GAAGAFIMQR CSLNAVKDLL TSCMNTLQLK EKHFTSTLSV SQYTAGAKNL
SLEEVIANSQ RNGSLDMHAN APKFTTYSDP EPSVGSAVGN EDSLHSILSQ SSRLSSLLNT
NDTGPAFTKS MQASLPLHDP LPYVVVNDPF LYCLRMTSLY NALCFTNSSL LRAVFDSYVS
NRKSLQTATT ANMVSFFCNI NGFGPDLYQK SWSEQDNNAR FFILSQYTAS IRKTSAPWRS
IPFVPNMVYT TETNVEISAF DMAYLLEGLM MLLPPSHTHK PDRAEPEDNN GNTQVPLVVC
DDLTHAQLLT MMYKCAFAGP DEILELSTTR RFATIFQRIL DTRSEILQHA QKSYLFYRQR
YRKIDPIPGV HVSELPVASL SHSLLYFSKV VAEFRLLCVH RHLQSLSRSP ISFRFRYGHK
DLQVILPSVS SRDAGRWRRY THISPKQSFE DTLQRQSVIL VFKGPDYALA SGASARLSLF
DAWLANSLPP IREILTKKGV FTESCVEHDA FVVTVPLQMT FTILPVIKGF MAANLEVENA
QIKKIVDQKE SSKHEKHKQG VDADNEDEQA KQESEADDIC VDEGVSK
//
