ID V6TH41_GIAIN Unreviewed; 561 AA.
AC V6TH41;
DT 19-FEB-2014, integrated into UniProtKB/TrEMBL.
DT 19-FEB-2014, sequence version 1.
DT 27-MAR-2024, entry version 37.
DE SubName: Full=Ankyrin repeat protein {ECO:0000313|EMBL:ESU36235.1};
GN ORFNames=DHA2_4843 {ECO:0000313|EMBL:ESU36235.1};
OS Giardia intestinalis (Giardia lamblia).
OC Eukaryota; Metamonada; Diplomonadida; Hexamitidae; Giardiinae; Giardia.
OX NCBI_TaxID=5741 {ECO:0000313|EMBL:ESU36235.1, ECO:0000313|Proteomes:UP000018320};
RN [1] {ECO:0000313|Proteomes:UP000018320}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=DH {ECO:0000313|Proteomes:UP000018320};
RA Adam R., Dahlstrom E., Martens C., Bruno D., Barbian K., Porcella S.F.,
RA Nash T.;
RT "Genome sequencing of Giardia lamblia Genotypes A2 and B isolates (DH and
RT GS) and comparative analysis with the genomes of Genotypes A1 and E (WB and
RT Pig).";
RL Submitted (FEB-2012) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|EMBL:ESU36235.1, ECO:0000313|Proteomes:UP000018320}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=DH {ECO:0000313|EMBL:ESU36235.1,
RC ECO:0000313|Proteomes:UP000018320};
RX PubMed=24307482; DOI=10.1093/gbe/evt197;
RA Adam R.D., Dahlstrom E.W., Martens C.A., Bruno D.P., Barbian K.D.,
RA Ricklefs S.M., Hernandez M.M., Narla N.P., Patel R.B., Porcella S.F.,
RA Nash T.E.;
RT "Genome sequencing of Giardia lamblia genotypes A2 and B isolates (DH and
RT GS) and comparative analysis with the genomes of genotypes A1 and E (WB and
RT Pig).";
RL Genome Biol. Evol. 5:2498-2511(2013).
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:ESU36235.1}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; AHGT01000053; ESU36235.1; -; Genomic_DNA.
DR AlphaFoldDB; V6TH41; -.
DR EnsemblProtists; ESU36235; ESU36235; DHA2_4843.
DR VEuPathDB; GiardiaDB:DHA2_4843; -.
DR VEuPathDB; GiardiaDB:GL50581_382; -.
DR VEuPathDB; GiardiaDB:GL50803_004843; -.
DR VEuPathDB; GiardiaDB:QR46_0483; -.
DR Proteomes; UP000018320; Unassembled WGS sequence.
DR GO; GO:0016740; F:transferase activity; IEA:UniProtKB-KW.
DR Gene3D; 1.25.40.20; Ankyrin repeat-containing domain; 3.
DR Gene3D; 3.30.40.10; Zinc/RING finger domain, C3HC4 (zinc finger); 1.
DR InterPro; IPR002110; Ankyrin_rpt.
DR InterPro; IPR036770; Ankyrin_rpt-contain_sf.
DR InterPro; IPR001841; Znf_RING.
DR InterPro; IPR013083; Znf_RING/FYVE/PHD.
DR PANTHER; PTHR24120:SF4; ANKYRIN REPEAT AND SOCS BOX PROTEIN 12; 1.
DR PANTHER; PTHR24120; GH07239P; 1.
DR Pfam; PF00023; Ank; 1.
DR Pfam; PF12796; Ank_2; 3.
DR Pfam; PF13920; zf-C3HC4_3; 1.
DR SMART; SM00248; ANK; 11.
DR SUPFAM; SSF48403; Ankyrin repeat; 2.
DR PROSITE; PS50297; ANK_REP_REGION; 2.
DR PROSITE; PS50088; ANK_REPEAT; 2.
DR PROSITE; PS50089; ZF_RING_2; 1.
PE 4: Predicted;
KW ANK repeat {ECO:0000256|PROSITE-ProRule:PRU00023};
KW Metal-binding {ECO:0000256|PROSITE-ProRule:PRU00175};
KW Transferase {ECO:0000256|ARBA:ARBA00022679};
KW Ubl conjugation pathway {ECO:0000256|ARBA:ARBA00022786};
KW Zinc {ECO:0000256|PROSITE-ProRule:PRU00175};
KW Zinc-finger {ECO:0000256|PROSITE-ProRule:PRU00175}.
FT REPEAT 191..213
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT REPEAT 222..254
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT DOMAIN 512..548
FT /note="RING-type"
FT /evidence="ECO:0000259|PROSITE:PS50089"
SQ SEQUENCE 561 AA; 61690 MW; 647989C727333396 CRC64;
MSILDKFTWF NVCRAGLVNQ IKDNIAKFKT VRDEVTGATA LMHACVDNNL EVVRILLPYE
DVITDNSGKT GLMIAAEHGY LDLARLLMVT QVGKQRENGQ TALMHAAAYD FEEVVELLLP
REGTMTDNNG WTALMCAAWR GSNKAALVLA KVEAGMASKQ GETAFLCACD AGNYELARLL
LEKEGRSTLR TGETGLHLAA RSGCKAIVEL LLEPLCRKQT KAGKTALMYA ASAGNLEIVM
LLLEKEVGYQ DTDGRTATMN AILNGHEGCM TALLPHEKEI VDKKGQTALI VAQSTTPSVM
SYHVAALLGG IIDPETGSTT LIQAARRGLS DIVRILVPAQ TNLADESGMC AIHYAVASHN
LECIRLLKQY EGKTLNANGH HALIMAVIEG DVSVILELIE HSWIPDAEGN YPITYCKEDP
LSDIYQLLFS HMMRTHPNFK AVTSAFCLAL HTCFSLLLND YPDNDDFEFL SEFLLLISDL
FFSPERITAT QITGEITMLL DSFTATVHEF PCCVCIDRPA FVIIRPCMHM CICNQCVASL
RGRCPYCQRA VTEHFEIALE K
//
