ID V6TIS6_GIAIN Unreviewed; 713 AA.
AC V6TIS6;
DT 19-FEB-2014, integrated into UniProtKB/TrEMBL.
DT 19-FEB-2014, sequence version 1.
DT 27-MAR-2024, entry version 34.
DE SubName: Full=RNA helicase {ECO:0000313|EMBL:ESU38888.1};
GN ORFNames=DHA2_15930 {ECO:0000313|EMBL:ESU38888.1};
OS Giardia intestinalis (Giardia lamblia).
OC Eukaryota; Metamonada; Diplomonadida; Hexamitidae; Giardiinae; Giardia.
OX NCBI_TaxID=5741 {ECO:0000313|EMBL:ESU38888.1, ECO:0000313|Proteomes:UP000018320};
RN [1] {ECO:0000313|Proteomes:UP000018320}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=DH {ECO:0000313|Proteomes:UP000018320};
RA Adam R., Dahlstrom E., Martens C., Bruno D., Barbian K., Porcella S.F.,
RA Nash T.;
RT "Genome sequencing of Giardia lamblia Genotypes A2 and B isolates (DH and
RT GS) and comparative analysis with the genomes of Genotypes A1 and E (WB and
RT Pig).";
RL Submitted (FEB-2012) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|EMBL:ESU38888.1, ECO:0000313|Proteomes:UP000018320}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=DH {ECO:0000313|EMBL:ESU38888.1,
RC ECO:0000313|Proteomes:UP000018320};
RX PubMed=24307482; DOI=10.1093/gbe/evt197;
RA Adam R.D., Dahlstrom E.W., Martens C.A., Bruno D.P., Barbian K.D.,
RA Ricklefs S.M., Hernandez M.M., Narla N.P., Patel R.B., Porcella S.F.,
RA Nash T.E.;
RT "Genome sequencing of Giardia lamblia genotypes A2 and B isolates (DH and
RT GS) and comparative analysis with the genomes of genotypes A1 and E (WB and
RT Pig).";
RL Genome Biol. Evol. 5:2498-2511(2013).
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:ESU38888.1}.
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DR EMBL; AHGT01000008; ESU38888.1; -; Genomic_DNA.
DR AlphaFoldDB; V6TIS6; -.
DR EnsemblProtists; ESU38888; ESU38888; DHA2_15930.
DR VEuPathDB; GiardiaDB:DHA2_15930; -.
DR VEuPathDB; GiardiaDB:GL50581_843; -.
DR VEuPathDB; GiardiaDB:GL50803_0015930; -.
DR VEuPathDB; GiardiaDB:QR46_0446; -.
DR Proteomes; UP000018320; Unassembled WGS sequence.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0004386; F:helicase activity; IEA:UniProtKB-KW.
DR GO; GO:0016787; F:hydrolase activity; IEA:UniProtKB-KW.
DR GO; GO:0003676; F:nucleic acid binding; IEA:InterPro.
DR CDD; cd17917; DEXHc_RHA-like; 1.
DR CDD; cd18791; SF2_C_RHA; 1.
DR Gene3D; 1.20.120.1080; -; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 2.
DR InterPro; IPR011709; DEAD-box_helicase_OB_fold.
DR InterPro; IPR011545; DEAD/DEAH_box_helicase_dom.
DR InterPro; IPR002464; DNA/RNA_helicase_DEAH_CS.
DR InterPro; IPR007502; Helicase-assoc_dom.
DR InterPro; IPR014001; Helicase_ATP-bd.
DR InterPro; IPR001650; Helicase_C.
DR InterPro; IPR027417; P-loop_NTPase.
DR PANTHER; PTHR18934; ATP-DEPENDENT RNA HELICASE; 1.
DR PANTHER; PTHR18934:SF83; PRE-MRNA-SPLICING FACTOR ATP-DEPENDENT RNA HELICASE DHX16; 1.
DR Pfam; PF00270; DEAD; 1.
DR Pfam; PF21010; HA2_C; 1.
DR Pfam; PF00271; Helicase_C; 1.
DR Pfam; PF07717; OB_NTP_bind; 1.
DR SMART; SM00487; DEXDc; 1.
DR SMART; SM00847; HA2; 1.
DR SMART; SM00490; HELICc; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR PROSITE; PS00690; DEAH_ATP_HELICASE; 1.
DR PROSITE; PS51192; HELICASE_ATP_BIND_1; 1.
DR PROSITE; PS51194; HELICASE_CTER; 1.
PE 4: Predicted;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW Helicase {ECO:0000313|EMBL:ESU38888.1};
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741}.
FT DOMAIN 26..170
FT /note="Helicase ATP-binding"
FT /evidence="ECO:0000259|PROSITE:PS51192"
FT DOMAIN 268..439
FT /note="Helicase C-terminal"
FT /evidence="ECO:0000259|PROSITE:PS51194"
SQ SEQUENCE 713 AA; 79284 MW; 467A1334F52010EE CRC64;
MPSQSTIQSE QRALPIYPIK KQLIDSILHS PQRVVVVVGS TGSGKSTQLP QYLIDANASI
KRITVTQPRR VAAISLALRV AQERGASLGQ EVGYSVRFDA KVSKSTRIRY ATDGVVIREA
LLDPLFHSDS IVIVDEAHER SVSTDLLFGF LKTALDKNPK LRVVVMSATI AAASFVRYFG
AHAANAILSI KGRQYPIKHY FTLEAVKSYQ EACVSAVLQI CKDCKSGDIL VFMPGELEIR
NVVAAIRNHC AKFGVLYEPE GADDNRPNCI DDNESLEDDD RLSLGPLFSN RDTIKPAGGF
TVQLPGEASL IEVLPFYANL PTTEQMRVFS SAAENVRRVI VATNIAETSI TVPNIRYVVD
CGFVRKKQFH HTTGTSELIT LPCSQASILQ RSGRAGRLME GECYHIYTHE TYANLEPQDV
PEIMLTDLMP VFLTIIAFGI TNPVTYEFIT DPPRQAKKAA IVKLSRMGCI QIKKTEDGVD
NQSQMEPQLI LSPLGREVVR FPTDPELAIS ILTAHKFGKK IVKDVVGVVA LLSCDGVFVS
SVDIETRDQS ALARTQFYSL KGDHITLLNI WKAYCEESEN KRAWCTKYYL SYKSLEYAKN
VYRQLIDIYN SYCKASRKGA GAETESPPCG LYTEMDDEDK VIFCILKGYI SNVAKLSNDH
RTYEGSSGEC RIHPASCLKQ NPNFVLYNEI VITSFAYMRT VSEINPAWIE MTV
//
