ID   V6TTQ2_GIAIN            Unreviewed;       981 AA.
AC   V6TTQ2;
DT   19-FEB-2014, integrated into UniProtKB/TrEMBL.
DT   19-FEB-2014, sequence version 1.
DT   27-MAR-2024, entry version 36.
DE   SubName: Full=Ankyrin repeat protein {ECO:0000313|EMBL:ESU41702.1};
GN   ORFNames=GSB_21799 {ECO:0000313|EMBL:ESU41702.1};
OS   Giardia intestinalis (Giardia lamblia).
OC   Eukaryota; Metamonada; Diplomonadida; Hexamitidae; Giardiinae; Giardia.
OX   NCBI_TaxID=5741 {ECO:0000313|EMBL:ESU41702.1, ECO:0000313|Proteomes:UP000018040};
RN   [1] {ECO:0000313|Proteomes:UP000018040}
RP   NUCLEOTIDE SEQUENCE.
RC   STRAIN=GS {ECO:0000313|Proteomes:UP000018040};
RA   Adam R., Dahlstrom E., Martens C., Bruno D., Barbian K., Porcella S.F.,
RA   Nash T.;
RT   "Genome sequencing of Giardia lamblia Genotypes A2 and B isolates (DH and
RT   GS) and comparative analysis with the genomes of Genotypes A1 and E (WB and
RT   Pig).";
RL   Submitted (FEB-2012) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|EMBL:ESU41702.1, ECO:0000313|Proteomes:UP000018040}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=GS {ECO:0000313|EMBL:ESU41702.1,
RC   ECO:0000313|Proteomes:UP000018040};
RX   PubMed=24307482; DOI=10.1093/gbe/evt197;
RA   Adam R.D., Dahlstrom E.W., Martens C.A., Bruno D.P., Barbian K.D.,
RA   Ricklefs S.M., Hernandez M.M., Narla N.P., Patel R.B., Porcella S.F.,
RA   Nash T.E.;
RT   "Genome sequencing of Giardia lamblia genotypes A2 and B isolates (DH and
RT   GS) and comparative analysis with the genomes of genotypes A1 and E (WB and
RT   Pig).";
RL   Genome Biol. Evol. 5:2498-2511(2013).
CC   -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC       whole genome shotgun (WGS) entry which is preliminary data.
CC       {ECO:0000313|EMBL:ESU41702.1}.
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DR   EMBL; AHHH01000114; ESU41702.1; -; Genomic_DNA.
DR   AlphaFoldDB; V6TTQ2; -.
DR   EnsemblProtists; ESU41702; ESU41702; GSB_21799.
DR   VEuPathDB; GiardiaDB:DHA2_21799; -.
DR   VEuPathDB; GiardiaDB:GL50581_3161; -.
DR   VEuPathDB; GiardiaDB:GL50803_0021799; -.
DR   VEuPathDB; GiardiaDB:QR46_4326; -.
DR   Proteomes; UP000018040; Unassembled WGS sequence.
DR   GO; GO:0016740; F:transferase activity; IEA:UniProtKB-KW.
DR   Gene3D; 1.25.40.20; Ankyrin repeat-containing domain; 6.
DR   Gene3D; 3.30.40.10; Zinc/RING finger domain, C3HC4 (zinc finger); 1.
DR   InterPro; IPR002110; Ankyrin_rpt.
DR   InterPro; IPR036770; Ankyrin_rpt-contain_sf.
DR   InterPro; IPR001841; Znf_RING.
DR   InterPro; IPR013083; Znf_RING/FYVE/PHD.
DR   PANTHER; PTHR24120:SF4; ANKYRIN REPEAT AND SOCS BOX PROTEIN 12; 1.
DR   PANTHER; PTHR24120; GH07239P; 1.
DR   Pfam; PF12796; Ank_2; 7.
DR   Pfam; PF13920; zf-C3HC4_3; 1.
DR   SMART; SM00248; ANK; 20.
DR   SUPFAM; SSF48403; Ankyrin repeat; 2.
DR   SUPFAM; SSF57850; RING/U-box; 1.
DR   PROSITE; PS50297; ANK_REP_REGION; 1.
DR   PROSITE; PS50088; ANK_REPEAT; 1.
DR   PROSITE; PS50089; ZF_RING_2; 1.
PE   4: Predicted;
KW   ANK repeat {ECO:0000256|PROSITE-ProRule:PRU00023};
KW   Metal-binding {ECO:0000256|PROSITE-ProRule:PRU00175};
KW   Transferase {ECO:0000256|ARBA:ARBA00022679};
KW   Ubl conjugation pathway {ECO:0000256|ARBA:ARBA00022786};
KW   Zinc {ECO:0000256|PROSITE-ProRule:PRU00175};
KW   Zinc-finger {ECO:0000256|PROSITE-ProRule:PRU00175}.
FT   REPEAT          77..109
FT                   /note="ANK"
FT                   /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT   DOMAIN          926..962
FT                   /note="RING-type"
FT                   /evidence="ECO:0000259|PROSITE:PS50089"
SQ   SEQUENCE   981 AA;  109013 MW;  3A4EA8D7D17F1DB9 CRC64;
     MKKILSRSFS MDGPISMTPL IVSAAANDVA GVRMYLGEYV GQTDQLGRTA LMWAAMHGHK
     ETVEALVSFE GGHQDNDGYT ALMYAASKGY VDSVRQLVDV EARMKNKDGV TALMCAVEKQ
     HVKVATILAD YEDRIQDNKG WTALMRAAKS NSITQFLFLV EREHSIADGK KWTSMMYAAS
     KGHLEAVEAL IFHESMLQDY EGKTALVIAS FLGYKALVER LYATEGSIAD RLGLTPMMWA
     AEKGHYEIVH FMSGTQARCQ DNRGWTALMR GAQNGFEKIV EILAPLESKL VDTNGFTALM
     YAAIKNKPAC AKLLAPWEKG FRNTGGLTAL IMASQFDHNN IIALLAEHEA SMSCSNGRTA
     LMTAAMHGNV EGARILAPYE ARARDGNGMT ALMHSVYIHA QDARVKHDVL VERRSEGLYE
     LHAEVANYLY DLECGMTDIR GMTALMHSMR DKNLIIISKL AETEPKMKDH DERTALMHAA
     LAGATDVVAF LSDSEAGMQD ANGYTAMIYA AQRNLHEFVK RLAPYEAGIQ DKYSMTALMW
     GFKLGFSQVV SHLLDYESGY QDKRGMSLLM MAATETDQQV LKELVIRHRL SLHHSKLPSS
     ASEVGLQDNE GQTALMHAAL CGNELAVQLL LPYEAGYQTP RGTTALMLAA TRGHKKIVEL
     LESKERTMQD VNGRTALMLA LQNKNFMLCR LLIMEIPIID NRYLSCYEYA IDPKVPGFSN
     LLLAGRLRLM SLSRLSCYIF YNHICSAFAQ LILNILKSSC NSLAQIKLRA STNLTILEQQ
     VSNALSSTDP CLELAMARPE ILSDESLLLN VMNPSDLKDL ELIFEICSSA MFDDLDPAAQ
     HLTQLTSIPN LVGYAERCEE PPPLLPETPS GVTHESTQTK SMLLEDQELS YSLQYHIQIV
     QEKLSEYTDT YNAFIYDIVP HVDTACIICM SWIVECVFIP CGHACCCHYC LEFSSHKCPV
     CRSDIKDFLM LPCEGTNLEE L
//