ID   V6TVV9_GIAIN            Unreviewed;       980 AA.
AC   V6TVV9;
DT   19-FEB-2014, integrated into UniProtKB/TrEMBL.
DT   19-FEB-2014, sequence version 1.
DT   27-MAR-2024, entry version 26.
DE   SubName: Full=Ankyrin repeat protein {ECO:0000313|EMBL:ESU42704.1};
GN   ORFNames=GSB_153591 {ECO:0000313|EMBL:ESU42704.1};
OS   Giardia intestinalis (Giardia lamblia).
OC   Eukaryota; Metamonada; Diplomonadida; Hexamitidae; Giardiinae; Giardia.
OX   NCBI_TaxID=5741 {ECO:0000313|EMBL:ESU42704.1, ECO:0000313|Proteomes:UP000018040};
RN   [1] {ECO:0000313|Proteomes:UP000018040}
RP   NUCLEOTIDE SEQUENCE.
RC   STRAIN=GS {ECO:0000313|Proteomes:UP000018040};
RA   Adam R., Dahlstrom E., Martens C., Bruno D., Barbian K., Porcella S.F.,
RA   Nash T.;
RT   "Genome sequencing of Giardia lamblia Genotypes A2 and B isolates (DH and
RT   GS) and comparative analysis with the genomes of Genotypes A1 and E (WB and
RT   Pig).";
RL   Submitted (FEB-2012) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|EMBL:ESU42704.1, ECO:0000313|Proteomes:UP000018040}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=GS {ECO:0000313|EMBL:ESU42704.1,
RC   ECO:0000313|Proteomes:UP000018040};
RX   PubMed=24307482; DOI=10.1093/gbe/evt197;
RA   Adam R.D., Dahlstrom E.W., Martens C.A., Bruno D.P., Barbian K.D.,
RA   Ricklefs S.M., Hernandez M.M., Narla N.P., Patel R.B., Porcella S.F.,
RA   Nash T.E.;
RT   "Genome sequencing of Giardia lamblia genotypes A2 and B isolates (DH and
RT   GS) and comparative analysis with the genomes of genotypes A1 and E (WB and
RT   Pig).";
RL   Genome Biol. Evol. 5:2498-2511(2013).
CC   -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC       whole genome shotgun (WGS) entry which is preliminary data.
CC       {ECO:0000313|EMBL:ESU42704.1}.
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DR   EMBL; AHHH01000073; ESU42704.1; -; Genomic_DNA.
DR   AlphaFoldDB; V6TVV9; -.
DR   EnsemblProtists; ESU42704; ESU42704; GSB_153591.
DR   VEuPathDB; GiardiaDB:DHA2_152015; -.
DR   VEuPathDB; GiardiaDB:GL50581_2509; -.
DR   VEuPathDB; GiardiaDB:GL50803_007154; -.
DR   VEuPathDB; GiardiaDB:QR46_3654; -.
DR   Proteomes; UP000018040; Unassembled WGS sequence.
DR   Gene3D; 1.25.40.20; Ankyrin repeat-containing domain; 2.
DR   InterPro; IPR002110; Ankyrin_rpt.
DR   InterPro; IPR036770; Ankyrin_rpt-contain_sf.
DR   InterPro; IPR011009; Kinase-like_dom_sf.
DR   PANTHER; PTHR24120:SF4; ANKYRIN REPEAT AND SOCS BOX PROTEIN 12; 1.
DR   PANTHER; PTHR24120; GH07239P; 1.
DR   Pfam; PF12796; Ank_2; 1.
DR   SMART; SM00248; ANK; 6.
DR   SUPFAM; SSF48403; Ankyrin repeat; 2.
DR   SUPFAM; SSF56112; Protein kinase-like (PK-like); 1.
PE   4: Predicted;
FT   REGION          333..354
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        340..354
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   980 AA;  108583 MW;  78DF3570B3A1CB98 CRC64;
     MASSCIWSTQ PFDKVSVVQE GQEAIVTLSL PRITNKHSNS IMQRLRKLTK LAHSHISPLI
     SHTYSPETSC LSLRYFVGNA VQLSKLLARS AEHDHTKRPI TETTILGILL HTASALGFIC
     SPIRSQIMNI PPQHHSFLSP DLLFITEATR MASVVAVGVY WSLLQPDESR GVDQALSSAC
     EKEDILVLGQ LMNNIIIQSS ELYSGLLKRI INLMLDENPQ NRPTFANLSI FLSSLIEMQQ
     NPQYKPRTIT TPAEELHPPR IIRRASTQIP NYQRSPSPSY DSYASPMRRS AEIPKASHHA
     QDIIEHLGHT APIKRPVSVL QKALKVESRP KAIPFPSTQL SPGPRMNTSS PIRGGVKPSR
     RYNLLFEAVE SNNIEEVRRL KEIFACGTDN FGNTALMRAL QLRSTDIAME LLPLEFQKRN
     NKGQLPLMIS LMEKMDAVTI ELLLNYDEFY GTTDDEGNTA LMYAVMSNFK KAVEALAAHE
     HSIPNKKGKY PIHVAIENAY IDLALYLLEY NSSVLDGEYR TLSEYCNLYS CTLVKDRLLT
     ISKQESSTSS DYTALMVAAG LNNIDDLYKY IPTQIGMRHV SGETALMIAI RKTQMDAMRI
     LLPYEFHLPD KAGHFFVYQA GLTGSRQIIT CALDSLFTDT MLMCLQLDEH LNEIAVELRG
     MVEDALTSND QDLLRSCIQD LDSIISHQVE TGAIATYYDD LWIGPSTPLL VPESAIHLGE
     TDLDIHALDI SNARTYAEAS TSSQLNERTI IHGSEVFKGS HVSNILKDST SATSLKLGRR
     SPSSLALSST AQASDGSRLN SKVSTLRNGN LHDHSSSANL PTEKRRNKIL LSASSVGFKE
     LSESLHSSST AAFSTDVNEY GNTPLTCSVL NSDISSVKNL AKKYACSLNN KGETALHTAL
     QMPNNSTTME MVRILAPLEW NVSSSSGAYP VELAAIRMLR EAFLILVEHD SRYSAESVEA
     IKKAIDEGDI ETIKRLVQST
//