ID   V6TWN4_GIAIN            Unreviewed;       946 AA.
AC   V6TWN4;
DT   19-FEB-2014, integrated into UniProtKB/TrEMBL.
DT   19-FEB-2014, sequence version 1.
DT   27-MAR-2024, entry version 30.
DE   SubName: Full=Ankyrin repeat protein {ECO:0000313|EMBL:ESU43141.1};
GN   ORFNames=GSB_151239 {ECO:0000313|EMBL:ESU43141.1};
OS   Giardia intestinalis (Giardia lamblia).
OC   Eukaryota; Metamonada; Diplomonadida; Hexamitidae; Giardiinae; Giardia.
OX   NCBI_TaxID=5741 {ECO:0000313|EMBL:ESU43141.1, ECO:0000313|Proteomes:UP000018040};
RN   [1] {ECO:0000313|Proteomes:UP000018040}
RP   NUCLEOTIDE SEQUENCE.
RC   STRAIN=GS {ECO:0000313|Proteomes:UP000018040};
RA   Adam R., Dahlstrom E., Martens C., Bruno D., Barbian K., Porcella S.F.,
RA   Nash T.;
RT   "Genome sequencing of Giardia lamblia Genotypes A2 and B isolates (DH and
RT   GS) and comparative analysis with the genomes of Genotypes A1 and E (WB and
RT   Pig).";
RL   Submitted (FEB-2012) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|EMBL:ESU43141.1, ECO:0000313|Proteomes:UP000018040}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=GS {ECO:0000313|EMBL:ESU43141.1,
RC   ECO:0000313|Proteomes:UP000018040};
RX   PubMed=24307482; DOI=10.1093/gbe/evt197;
RA   Adam R.D., Dahlstrom E.W., Martens C.A., Bruno D.P., Barbian K.D.,
RA   Ricklefs S.M., Hernandez M.M., Narla N.P., Patel R.B., Porcella S.F.,
RA   Nash T.E.;
RT   "Genome sequencing of Giardia lamblia genotypes A2 and B isolates (DH and
RT   GS) and comparative analysis with the genomes of genotypes A1 and E (WB and
RT   Pig).";
RL   Genome Biol. Evol. 5:2498-2511(2013).
CC   -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC       whole genome shotgun (WGS) entry which is preliminary data.
CC       {ECO:0000313|EMBL:ESU43141.1}.
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DR   EMBL; AHHH01000058; ESU43141.1; -; Genomic_DNA.
DR   AlphaFoldDB; V6TWN4; -.
DR   EnsemblProtists; ESU43141; ESU43141; GSB_151239.
DR   VEuPathDB; GiardiaDB:DHA2_153454; -.
DR   VEuPathDB; GiardiaDB:GL50581_27; -.
DR   VEuPathDB; GiardiaDB:GL50803_005468; -.
DR   VEuPathDB; GiardiaDB:QR46_2548; -.
DR   Proteomes; UP000018040; Unassembled WGS sequence.
DR   Gene3D; 1.25.40.20; Ankyrin repeat-containing domain; 3.
DR   Gene3D; 1.10.510.10; Transferase(Phosphotransferase) domain 1; 1.
DR   InterPro; IPR002110; Ankyrin_rpt.
DR   InterPro; IPR036770; Ankyrin_rpt-contain_sf.
DR   InterPro; IPR011009; Kinase-like_dom_sf.
DR   PANTHER; PTHR24120:SF4; ANKYRIN REPEAT AND SOCS BOX PROTEIN 12; 1.
DR   PANTHER; PTHR24120; GH07239P; 1.
DR   Pfam; PF12796; Ank_2; 4.
DR   SMART; SM00248; ANK; 11.
DR   SUPFAM; SSF48403; Ankyrin repeat; 2.
DR   SUPFAM; SSF56112; Protein kinase-like (PK-like); 1.
DR   PROSITE; PS50297; ANK_REP_REGION; 1.
DR   PROSITE; PS50088; ANK_REPEAT; 1.
PE   4: Predicted;
KW   ANK repeat {ECO:0000256|PROSITE-ProRule:PRU00023}.
FT   REPEAT          857..889
FT                   /note="ANK"
FT                   /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT   REGION          1..22
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   946 AA;  104550 MW;  185F237DA953FC58 CRC64;
     MPCSMSSHGH SHPSKSSPGD GRRDGQLLQP GIYWALLAEL MSVVLRIILP QLNVPHEGIN
     MDTFLQLLGS CKRIHSETQE DAPAKSGLLS EVTILEFLMV ACDTVLEFNY CDERRQLHPD
     AQLFRRADRR FRPPDLSTYH SNPSLLGVWA LGCISYELYF LQQVSGPLLR DYYSSSPITN
     TQELIRRCLA VDPHERISAV ALREKAARVL AAEEKTLLFL TPPRPKLLYE WIEAPSDSPP
     LKDEHLTAPL NLFIHDSPYT FLASRSEPRD AEPLAVGARS PLIEAVRRAD IKEVRRLIET
     GQIYQHLRQY DAEAGRTALM IAAEMGSEAI VKELLDIKYI IPQFTTTPVN CAEEAGIVMH
     LDSWSEQRHN FLVRCRGYRP VTEEKLEALL ELGQMDGLFC ALSLALRAGH WSCVKHLAQY
     EVGLAGFTPL MAAAVSGDAN LTLKSLQYLN CQCEGITATM LAALYGNIKC LEIMLSAVAS
     DVLSASATLN RQERELPLEL SSSTSKMTGS LNTAMLAIAT DHPESLQTLL FHVPSIMRYQ
     NAIGQTALML AAAKGYDALV TMMLPHEFSL YDSYGQTVVS YAAGSTSYGP GSAACLNAVA
     DYFLANCGIT DIIYNTIRCS ITHIDVHDPL ILEQAGKTDR LGRCALMYAI ETHNTTLVNS
     LLAIEASMPY KRRRDDLYLE DDKMVSSNII DHALDIKAYV VLPTICAYYA ANPTVFLRSL
     PCINRTGIYG SEQTKLMKVV EEVGLHTEHI PGEYLNDCCK VAALRRGLMS ALALAASNSD
     VESVCPLLRE MCIQLSPYKP ALYYAIKAQN VSCANLLLPE VHLWGGTYLM AYAALGDATA
     VERLIKLNCD IRSYSEGGWT ALMFAARYGH VNCVKLLLEY EGGMATNERY KSGIGVTALI
     IAVQHNHLSC AQALCSKERD IKAKDGRKAV DIAREENKRS LVAILL
//