ID V6U4N8_GIAIN Unreviewed; 1284 AA.
AC V6U4N8;
DT 19-FEB-2014, integrated into UniProtKB/TrEMBL.
DT 19-FEB-2014, sequence version 1.
DT 28-JUN-2023, entry version 26.
DE SubName: Full=Preribosomal RNA processing essential GTPase Bms1 {ECO:0000313|EMBL:ESU45794.1};
GN ORFNames=GSB_102722 {ECO:0000313|EMBL:ESU45794.1};
OS Giardia intestinalis (Giardia lamblia).
OC Eukaryota; Metamonada; Diplomonadida; Hexamitidae; Giardiinae; Giardia.
OX NCBI_TaxID=5741 {ECO:0000313|EMBL:ESU45794.1, ECO:0000313|Proteomes:UP000018040};
RN [1] {ECO:0000313|Proteomes:UP000018040}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=GS {ECO:0000313|Proteomes:UP000018040};
RA Adam R., Dahlstrom E., Martens C., Bruno D., Barbian K., Porcella S.F.,
RA Nash T.;
RT "Genome sequencing of Giardia lamblia Genotypes A2 and B isolates (DH and
RT GS) and comparative analysis with the genomes of Genotypes A1 and E (WB and
RT Pig).";
RL Submitted (FEB-2012) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|EMBL:ESU45794.1, ECO:0000313|Proteomes:UP000018040}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=GS {ECO:0000313|EMBL:ESU45794.1,
RC ECO:0000313|Proteomes:UP000018040};
RX PubMed=24307482; DOI=10.1093/gbe/evt197;
RA Adam R.D., Dahlstrom E.W., Martens C.A., Bruno D.P., Barbian K.D.,
RA Ricklefs S.M., Hernandez M.M., Narla N.P., Patel R.B., Porcella S.F.,
RA Nash T.E.;
RT "Genome sequencing of Giardia lamblia genotypes A2 and B isolates (DH and
RT GS) and comparative analysis with the genomes of genotypes A1 and E (WB and
RT Pig).";
RL Genome Biol. Evol. 5:2498-2511(2013).
CC -!- SUBCELLULAR LOCATION: Nucleus, nucleolus
CC {ECO:0000256|ARBA:ARBA00004604}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:ESU45794.1}.
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DR EMBL; AHHH01000001; ESU45794.1; -; Genomic_DNA.
DR EnsemblProtists; ESU45794; ESU45794; GSB_102722.
DR VEuPathDB; GiardiaDB:DHA2_102722; -.
DR VEuPathDB; GiardiaDB:GL50581_468; -.
DR VEuPathDB; GiardiaDB:GL50803_00102722; -.
DR VEuPathDB; GiardiaDB:QR46_0895; -.
DR Proteomes; UP000018040; Unassembled WGS sequence.
DR GO; GO:0005730; C:nucleolus; IEA:UniProtKB-SubCell.
DR GO; GO:0042254; P:ribosome biogenesis; IEA:UniProtKB-KW.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR InterPro; IPR012948; AARP2CN.
DR InterPro; IPR039761; Bms1/Tsr1.
DR InterPro; IPR007034; BMS1_TSR1_C.
DR InterPro; IPR030387; G_Bms1/Tsr1_dom.
DR InterPro; IPR027417; P-loop_NTPase.
DR PANTHER; PTHR12858; RIBOSOME BIOGENESIS PROTEIN; 1.
DR PANTHER; PTHR12858:SF2; RIBOSOME BIOGENESIS PROTEIN BMS1 HOMOLOG; 1.
DR Pfam; PF08142; AARP2CN; 1.
DR Pfam; PF04950; RIBIOP_C; 1.
DR SMART; SM00785; AARP2CN; 1.
DR SMART; SM01362; DUF663; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR PROSITE; PS51714; G_BMS1; 1.
PE 4: Predicted;
KW Coiled coil {ECO:0000256|SAM:Coils};
KW Nucleus {ECO:0000256|ARBA:ARBA00023242};
KW Ribosome biogenesis {ECO:0000256|ARBA:ARBA00022517}.
FT DOMAIN 88..253
FT /note="Bms1-type G"
FT /evidence="ECO:0000259|PROSITE:PS51714"
FT REGION 1..38
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 422..467
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 480..500
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 517..546
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 806..836
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 1225..1257
FT /evidence="ECO:0000256|SAM:Coils"
FT COMPBIAS 1..17
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 422..459
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 486..500
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 520..542
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1284 AA; 145504 MW; A29520C7C74E4444 CRC64;
MSDRQVTDEQ ENTKHKSTKS TRGRKNKQKK RENVREAIKN GTRPHHVNMK AYSFQSVVAA
RRVIQRQANA LQRAARLPYV ARYGDYPPPD LVAVIGPKGV GKTTLTKALV RVVGGYSVSD
PIGPITVVAS KTKRITFYDV PASIPAILDI SKLVNLVIIV VNAKVGLEVE HYEYLNILQA
TGFPRVFTVF THLDEFSKAR AMRNEKVRLR ERIWKEVYPG SRVFYMNGLA YGRTYHKTDM
ALLARILSRQ EYKLGLNWRD NHAGVLIDRI EDITDPGLLS KVNQEKNKLV KHKLLVYGYV
RGTYMDPAQH FCIPGAGNVI VKSMKPLPDP CRCFEQQKKD GDARRSLSSK TKTVYAPFSN
MGDVFHDKDG LWLRIHETGV QWKDKDEDEL PAGLKMLRNL EELDPQEKDK AMLGIRLMDD
SDRELDSQQH QTDEPECSSE ADTKEESISQ QQDKEHEEEI GQSSDEEENA FLRDAQLVQQ
DSSAKQAEHG NDHLSFEESS ENVADIDYDM MMIGRKAAST DSDSADTAAD SVSASEPGNE
PSNGEAATEE MHALADDMYA SIHLATPVGA KIALEDLVYN MDGILAEMKA KGVSPAMTRT
TRSAAVMSKL VPLFDDDGPD LYRGSAVTID KFSLLPIYDP EKAMQFDGLV ARSGGSALYT
GVSLAGKNFY KLESYRDISN VIPKDVVYSQ AFTETLQGSS RKQLSGLHLA DIDWKRTKNS
VCTGDWDMAK ILDAVLHGEV YKGKEHRRDG SGGVHVAEDG VLEIGYQAAP EQDTTEPTHQ
AGLEYTLPRS KHGKHTNQSV ADKKLANDAN ELLEGLELNN DGIEKNQREM DEAKERESAF
AKAFTDESRF PPGTYLRIEL EGIDHEFAKN YASVNPLVLG VVLPGEQNYG YITAKVKRHR
WHDKILKTKN PVFVSCGWKR YQTVPYYSME QQGSMADINT DEVTEAGRHR MLKYTPENMY
CYCTFWGPIV PANTGFLFFD TVDDTQRSFR IGATGTVVNT GLKHMVYKKL KLVGAVNKVF
RNTAFIEKLF TSKLEAMAFI GAGIRTVSGI RGIIKKAEKQ PEGLVRATFE DKVAHSDIVF
LRTYVPITII KFCYEMLNHY YVYDDYTREY IIPGEKKSRH EQPLRIKTFA ELRHERNLPI
PINPDSIYVQ KTARVVDQFI EDEHRDELLN MVPTRLLKSL PFENQREIVI AKNKPDLIKD
EFLKSLADGS GAEHEREKVL NDLLVVKKDQ DRKQLEMQKK EEEDKKIEEE IKAMHIREKT
KELRKRKRIV RQKHEEKRIS AKKI
//
