ID V7BGQ6_PHAVU Unreviewed; 508 AA.
AC V7BGQ6;
DT 19-FEB-2014, integrated into UniProtKB/TrEMBL.
DT 19-FEB-2014, sequence version 1.
DT 27-MAR-2024, entry version 51.
DE RecName: Full=Aspartic proteinase {ECO:0008006|Google:ProtNLM};
GN ORFNames=PHAVU_007G205100g {ECO:0000313|EMBL:ESW17037.1};
OS Phaseolus vulgaris (Kidney bean) (French bean).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC rosids; fabids; Fabales; Fabaceae; Papilionoideae; 50 kb inversion clade;
OC NPAAA clade; indigoferoid/millettioid clade; Phaseoleae; Phaseolus.
OX NCBI_TaxID=3885 {ECO:0000313|EMBL:ESW17037.1, ECO:0000313|Proteomes:UP000000226};
RN [1] {ECO:0000313|Proteomes:UP000000226}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. G19833 {ECO:0000313|Proteomes:UP000000226};
RX PubMed=24908249; DOI=10.1038/ng.3008;
RA Schmutz J., McClean P.E., Mamidi S., Wu G.A., Cannon S.B., Grimwood J.,
RA Jenkins J., Shu S., Song Q., Chavarro C., Torres-Torres M., Geffroy V.,
RA Moghaddam S.M., Gao D., Abernathy B., Barry K., Blair M., Brick M.A.,
RA Chovatia M., Gepts P., Goodstein D.M., Gonzales M., Hellsten U.,
RA Hyten D.L., Jia G., Kelly J.D., Kudrna D., Lee R., Richard M.M.,
RA Miklas P.N., Osorno J.M., Rodrigues J., Thareau V., Urrea C.A., Wang M.,
RA Yu Y., Zhang M., Wing R.A., Cregan P.B., Rokhsar D.S., Jackson S.A.;
RT "A reference genome for common bean and genome-wide analysis of dual
RT domestications.";
RL Nat. Genet. 46:707-713(2014).
CC -!- SIMILARITY: Belongs to the peptidase A1 family.
CC {ECO:0000256|ARBA:ARBA00007447, ECO:0000256|RuleBase:RU000454}.
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DR EMBL; CM002294; ESW17037.1; -; Genomic_DNA.
DR RefSeq; XP_007145043.1; XM_007144981.1.
DR AlphaFoldDB; V7BGQ6; -.
DR STRING; 3885.V7BGQ6; -.
DR MEROPS; A01.020; -.
DR EnsemblPlants; ESW17037; ESW17037; PHAVU_007G205100g.
DR GeneID; 18626516; -.
DR Gramene; ESW17037; ESW17037; PHAVU_007G205100g.
DR KEGG; pvu:PHAVU_007G205100g; -.
DR eggNOG; KOG1339; Eukaryota.
DR OMA; EYLVICR; -.
DR OrthoDB; 1120702at2759; -.
DR Proteomes; UP000000226; Chromosome 7.
DR GO; GO:0004190; F:aspartic-type endopeptidase activity; IEA:UniProtKB-KW.
DR GO; GO:0006629; P:lipid metabolic process; IEA:InterPro.
DR GO; GO:0006508; P:proteolysis; IEA:UniProtKB-KW.
DR CDD; cd06098; phytepsin; 1.
DR Gene3D; 2.40.70.10; Acid Proteases; 2.
DR Gene3D; 1.10.225.10; Saposin-like; 1.
DR InterPro; IPR001461; Aspartic_peptidase_A1.
DR InterPro; IPR001969; Aspartic_peptidase_AS.
DR InterPro; IPR033121; PEPTIDASE_A1.
DR InterPro; IPR021109; Peptidase_aspartic_dom_sf.
DR InterPro; IPR033869; Phytepsin.
DR InterPro; IPR007856; SapB_1.
DR InterPro; IPR008138; SapB_2.
DR InterPro; IPR011001; Saposin-like.
DR InterPro; IPR008139; SaposinB_dom.
DR PANTHER; PTHR47966; BETA-SITE APP-CLEAVING ENZYME, ISOFORM A-RELATED; 1.
DR PANTHER; PTHR47966:SF28; PLASMEPSIN X; 1.
DR Pfam; PF00026; Asp; 1.
DR Pfam; PF05184; SapB_1; 1.
DR Pfam; PF03489; SapB_2; 1.
DR PRINTS; PR00792; PEPSIN.
DR SUPFAM; SSF50630; Acid proteases; 1.
DR SUPFAM; SSF47862; Saposin; 1.
DR PROSITE; PS00141; ASP_PROTEASE; 2.
DR PROSITE; PS51767; PEPTIDASE_A1; 1.
DR PROSITE; PS50015; SAP_B; 2.
PE 3: Inferred from homology;
KW Aspartyl protease {ECO:0000256|ARBA:ARBA00022750,
KW ECO:0000256|RuleBase:RU000454};
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157,
KW ECO:0000256|PIRSR:PIRSR601461-2};
KW Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801, ECO:0000256|RuleBase:RU000454};
KW Protease {ECO:0000256|RuleBase:RU000454};
KW Reference proteome {ECO:0000313|Proteomes:UP000000226};
KW Signal {ECO:0000256|SAM:SignalP}.
FT SIGNAL 1..18
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 19..508
FT /note="Aspartic proteinase"
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5004754529"
FT DOMAIN 85..505
FT /note="Peptidase A1"
FT /evidence="ECO:0000259|PROSITE:PS51767"
FT DOMAIN 315..355
FT /note="Saposin B-type"
FT /evidence="ECO:0000259|PROSITE:PS50015"
FT DOMAIN 378..419
FT /note="Saposin B-type"
FT /evidence="ECO:0000259|PROSITE:PS50015"
FT ACT_SITE 103
FT /evidence="ECO:0000256|PIRSR:PIRSR601461-1"
FT ACT_SITE 290
FT /evidence="ECO:0000256|PIRSR:PIRSR601461-1"
FT DISULFID 116..122
FT /evidence="ECO:0000256|PIRSR:PIRSR601461-2"
FT DISULFID 281..285
FT /evidence="ECO:0000256|PIRSR:PIRSR601461-2"
SQ SEQUENCE 508 AA; 55697 MW; 105044826042A0A6 CRC64;
MGNTYLLLTF CLWALTCSLL PSFSCGLMKI GLKKRDVDLD SIRTARMVRE KLRIGRPVLG
AYDQYLGKPT DEGIVPLKNY LDAQYYGEIG IGTPPQKFNV IFDTGSSNLW VPSSKCYFSL
ACYTHKWYKP KKSKTYIKNG TSCKISYGSG SISGFFSEDS VKVGDIVVKK QDFIEATREG
SLSFLLAKFD GLLGLGFQEI SVENAVPVWY NMVQQNLVSD QVFSFWLNGD PSAKEGGELV
FGGVDPKHFK GNHTYVPVTK KGYWQIEMGD FFVGGLSTGV CEGGCAAIVD SGTSLLAGPT
TVVTEINHAI GAEGVLSVEC KEVVSEYGEL LWDLLISGVR PGDVCSQVGL CVAKRGQSES
NGIEMVTEKE HRELSAKDTV LCTPCQMLVI WIQNQLKQQK TKETVFNYVN QLCENLPSPN
GESVVNCNGI SGLPNITFTV GDKPFTLTPE QYILKTGEGI AEVCISGFIA FDIPPPRGPL
WILGDVFMRV YHTVFDYGNL RVGFAKAA
//
