ID V7CSW0_PHAVU Unreviewed; 1301 AA.
AC V7CSW0;
DT 19-FEB-2014, integrated into UniProtKB/TrEMBL.
DT 19-FEB-2014, sequence version 1.
DT 27-MAR-2024, entry version 47.
DE RecName: Full=ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase {ECO:0000256|ARBA:ARBA00011982};
DE EC=3.2.2.6 {ECO:0000256|ARBA:ARBA00011982};
GN ORFNames=PHAVU_002G323800g {ECO:0000313|EMBL:ESW32453.1};
OS Phaseolus vulgaris (Kidney bean) (French bean).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC rosids; fabids; Fabales; Fabaceae; Papilionoideae; 50 kb inversion clade;
OC NPAAA clade; indigoferoid/millettioid clade; Phaseoleae; Phaseolus.
OX NCBI_TaxID=3885 {ECO:0000313|EMBL:ESW32453.1, ECO:0000313|Proteomes:UP000000226};
RN [1] {ECO:0000313|EMBL:ESW32453.1}
RP NUCLEOTIDE SEQUENCE.
RA Schmutz J., McClean P., Shu S., Cregan P., Rokhsar D., Jackson S.;
RL Submitted (APR-2013) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Proteomes:UP000000226}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. G19833 {ECO:0000313|Proteomes:UP000000226};
RX PubMed=24908249; DOI=10.1038/ng.3008;
RA Schmutz J., McClean P.E., Mamidi S., Wu G.A., Cannon S.B., Grimwood J.,
RA Jenkins J., Shu S., Song Q., Chavarro C., Torres-Torres M., Geffroy V.,
RA Moghaddam S.M., Gao D., Abernathy B., Barry K., Blair M., Brick M.A.,
RA Chovatia M., Gepts P., Goodstein D.M., Gonzales M., Hellsten U.,
RA Hyten D.L., Jia G., Kelly J.D., Kudrna D., Lee R., Richard M.M.,
RA Miklas P.N., Osorno J.M., Rodrigues J., Thareau V., Urrea C.A., Wang M.,
RA Yu Y., Zhang M., Wing R.A., Cregan P.B., Rokhsar D.S., Jackson S.A.;
RT "A reference genome for common bean and genome-wide analysis of dual
RT domestications.";
RL Nat. Genet. 46:707-713(2014).
CC -!- CATALYTIC ACTIVITY:
CC Reaction=H2O + NAD(+) = ADP-D-ribose + H(+) + nicotinamide;
CC Xref=Rhea:RHEA:16301, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378,
CC ChEBI:CHEBI:17154, ChEBI:CHEBI:57540, ChEBI:CHEBI:57967; EC=3.2.2.6;
CC Evidence={ECO:0000256|ARBA:ARBA00000404};
CC PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:16302;
CC Evidence={ECO:0000256|ARBA:ARBA00000404};
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DR EMBL; CM002289; ESW32451.1; -; Genomic_DNA.
DR EMBL; CM002289; ESW32452.1; -; Genomic_DNA.
DR EMBL; CM002289; ESW32453.1; -; Genomic_DNA.
DR RefSeq; XP_007160457.1; XM_007160395.1.
DR RefSeq; XP_007160458.1; XM_007160396.1.
DR RefSeq; XP_007160459.1; XM_007160397.1.
DR EnsemblPlants; ESW32451; ESW32451; PHAVU_002G323800g.
DR EnsemblPlants; ESW32452; ESW32452; PHAVU_002G323800g.
DR EnsemblPlants; ESW32453; ESW32453; PHAVU_002G323800g.
DR GeneID; 18639804; -.
DR Gramene; ESW32451; ESW32451; PHAVU_002G323800g.
DR Gramene; ESW32452; ESW32452; PHAVU_002G323800g.
DR Gramene; ESW32453; ESW32453; PHAVU_002G323800g.
DR KEGG; pvu:PHAVU_002G323800g; -.
DR eggNOG; ENOG502SI7S; Eukaryota.
DR OMA; IMEDMEC; -.
DR OrthoDB; 949558at2759; -.
DR Proteomes; UP000000226; Chromosome 2.
DR GO; GO:0043531; F:ADP binding; IEA:InterPro.
DR GO; GO:0016887; F:ATP hydrolysis activity; IEA:InterPro.
DR GO; GO:0008757; F:S-adenosylmethionine-dependent methyltransferase activity; IEA:UniProt.
DR GO; GO:0006952; P:defense response; IEA:UniProtKB-KW.
DR GO; GO:0007165; P:signal transduction; IEA:InterPro.
DR Gene3D; 1.10.8.430; Helical domain of apoptotic protease-activating factors; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR Gene3D; 3.80.10.10; Ribonuclease Inhibitor; 3.
DR Gene3D; 3.40.50.10140; Toll/interleukin-1 receptor homology (TIR) domain; 1.
DR InterPro; IPR003593; AAA+_ATPase.
DR InterPro; IPR042197; Apaf_helical.
DR InterPro; IPR045344; C-JID.
DR InterPro; IPR044974; Disease_R_plants.
DR InterPro; IPR011713; Leu-rich_rpt_3.
DR InterPro; IPR032675; LRR_dom_sf.
DR InterPro; IPR002182; NB-ARC.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR000157; TIR_dom.
DR InterPro; IPR035897; Toll_tir_struct_dom_sf.
DR InterPro; IPR036390; WH_DNA-bd_sf.
DR PANTHER; PTHR11017:SF591; ADP-RIBOSYL CYCLASE_CYCLIC ADP-RIBOSE HYDROLASE; 1.
DR PANTHER; PTHR11017; LEUCINE-RICH REPEAT-CONTAINING PROTEIN; 1.
DR Pfam; PF20160; C-JID; 1.
DR Pfam; PF07725; LRR_3; 1.
DR Pfam; PF00931; NB-ARC; 1.
DR Pfam; PF01582; TIR; 1.
DR PRINTS; PR00364; DISEASERSIST.
DR SMART; SM00382; AAA; 1.
DR SMART; SM00255; TIR; 1.
DR SUPFAM; SSF52058; L domain-like; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR SUPFAM; SSF52047; RNI-like; 1.
DR SUPFAM; SSF52200; Toll/Interleukin receptor TIR domain; 1.
DR SUPFAM; SSF46785; Winged helix' DNA-binding domain; 1.
DR PROSITE; PS50104; TIR; 1.
PE 4: Predicted;
KW NAD {ECO:0000256|ARBA:ARBA00023027};
KW Plant defense {ECO:0000256|ARBA:ARBA00022821};
KW Reference proteome {ECO:0000313|Proteomes:UP000000226}.
FT DOMAIN 15..181
FT /note="TIR"
FT /evidence="ECO:0000259|PROSITE:PS50104"
FT REGION 1276..1301
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1301 AA; 147606 MW; 5AAFE28932DBAE4A CRC64;
MSASSSSLAM SASLTKHDVF LSFRGEDTRD NFISHLHPAL QRKNIEAYID ETLPRGEEIS
SALLSAIEES KIYIVVFSQN YASSTWCLNE LTKILDCKKR YGRDVIPVFY KVDPSTIRKQ
EQRYKEAFEK HEQQFKHDMD KVQGWKDALT EAAGLSGWDS KVTRSEHTLV EGIVGDILRK
LNRYSTSYDQ GIIGIEKNIE GIQSLLHLDL PDVRIIGICG MGGIGKSTIC DQIYHKLELQ
FDSRSLVLDV QEKIQRDGID SIRTKYLSEL KRTKVLLILD DVTDSAQLQK LIRGSDSFGQ
GSRIIITSRD RQVLRNAGAD DIYEVKELNF NDSQKLFSLH AFKQKSSEEI GYRELSKKVL
TYAKGIPLAL QILGSLLYGR TKEAWESQLQ KLKKGQHLGI FNVLKLSYDW LEEEEKNIFL
DIACFYRGRQ EIEVAERLDD FGFSSKIGMD ILKDRGLISV IDGRIVMHDL IQEMGKEIVH
KECPQHPGKR SRLFNDEEIC EVLRKNKGSD AIQCILLNTW GTWKVKEVVV HAQSFEKMDN
LRMLRLYTLG LESKVSPESS LVGLPDTLKI LYWDDFPQRF WPPKFCPQNL VTLEMPRNHL
EQLWEGDQNL PKLKRLNLSH SSNLTRIPDL STSPNIEEIK LSYCSKLIEV HSSIFLSKLS
CLCLDHCYDL NSVNIPNNIL STLPGLIILS CCRKLNMFST SEPRFPHMKL RHKRGNMIVE
AQCASGVHIF RSSSEIFSIT FDRYNEEVAN NTLYLQFEVS ANLRGGVPLN FQSLKNLCYL
DLSDCSSLTI FPFDLSDMKF LKQLSLRGCS KLEYLPQIQD TLEDLAVLIL DDTAIQALPS
SLCRLVGLQQ LSLRSCFNLQ IIPSSIGTLT RLCKLDLTHC NSLQTFPSTI FNLKLRKFDL
GGCSRLRSFP EITEPAHTFA HINLTSTAVK ELPSSFGNLV NLRSLELHKC TDLDSLPNCI
VNLKLLSKLD CSGCPKLTEI PRHIGRLTSL MKLSLRNSGI VNLPGSIAHL SSLKSLDLSD
CKKLECIPQI PPFLKQLVAL DCPSIRRVMP NSLVRNLSNS EEGVFKFHFT NAQQLDSGGR
ANIEEDARLR MTDDAYRCVF FCFPGSAVPG WFNFRGKGHS VTINEDLSFC SDDRLTGFAL
SVVFGVLDTY AMNGRYGSFS YSLTFESDDD GTQIIPNNDV LNSYFKWNGE ERCVDKDHTF
VWKFNLESLR ASGMSLRLCD ARSFTFEISP CDYDFGWPDY ESVVRELKSV ITIKECGICP
LYTKKKDDEY GGAVEIEESS GSNVAQSSRE TREDRKWKAE S
//
