ID V7D2B4_PHAVU Unreviewed; 669 AA.
AC V7D2B4;
DT 19-FEB-2014, integrated into UniProtKB/TrEMBL.
DT 19-FEB-2014, sequence version 1.
DT 27-MAR-2024, entry version 32.
DE RecName: Full=Nicastrin {ECO:0000256|ARBA:ARBA00015303};
GN ORFNames=PHAVU_001G228700g {ECO:0000313|EMBL:ESW35361.1};
OS Phaseolus vulgaris (Kidney bean) (French bean).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC rosids; fabids; Fabales; Fabaceae; Papilionoideae; 50 kb inversion clade;
OC NPAAA clade; indigoferoid/millettioid clade; Phaseoleae; Phaseolus.
OX NCBI_TaxID=3885 {ECO:0000313|EMBL:ESW35361.1, ECO:0000313|Proteomes:UP000000226};
RN [1] {ECO:0000313|Proteomes:UP000000226}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. G19833 {ECO:0000313|Proteomes:UP000000226};
RX PubMed=24908249; DOI=10.1038/ng.3008;
RA Schmutz J., McClean P.E., Mamidi S., Wu G.A., Cannon S.B., Grimwood J.,
RA Jenkins J., Shu S., Song Q., Chavarro C., Torres-Torres M., Geffroy V.,
RA Moghaddam S.M., Gao D., Abernathy B., Barry K., Blair M., Brick M.A.,
RA Chovatia M., Gepts P., Goodstein D.M., Gonzales M., Hellsten U.,
RA Hyten D.L., Jia G., Kelly J.D., Kudrna D., Lee R., Richard M.M.,
RA Miklas P.N., Osorno J.M., Rodrigues J., Thareau V., Urrea C.A., Wang M.,
RA Yu Y., Zhang M., Wing R.A., Cregan P.B., Rokhsar D.S., Jackson S.A.;
RT "A reference genome for common bean and genome-wide analysis of dual
RT domestications.";
RL Nat. Genet. 46:707-713(2014).
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004479}; Single-
CC pass type I membrane protein {ECO:0000256|ARBA:ARBA00004479}.
CC -!- SIMILARITY: Belongs to the nicastrin family.
CC {ECO:0000256|ARBA:ARBA00007717}.
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DR EMBL; CM002288; ESW35361.1; -; Genomic_DNA.
DR RefSeq; XP_007163367.1; XM_007163305.1.
DR AlphaFoldDB; V7D2B4; -.
DR STRING; 3885.V7D2B4; -.
DR EnsemblPlants; ESW35361; ESW35361; PHAVU_001G228700g.
DR GeneID; 18642272; -.
DR Gramene; ESW35361; ESW35361; PHAVU_001G228700g.
DR KEGG; pvu:PHAVU_001G228700g; -.
DR eggNOG; KOG2657; Eukaryota.
DR OMA; ECVYPGV; -.
DR OrthoDB; 1330770at2759; -.
DR Proteomes; UP000000226; Chromosome 1.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProt.
DR GO; GO:0007219; P:Notch signaling pathway; IEA:UniProtKB-KW.
DR GO; GO:0016485; P:protein processing; IEA:InterPro.
DR CDD; cd03881; M28_Nicastrin; 1.
DR Gene3D; 3.40.630.10; Zn peptidases; 1.
DR InterPro; IPR041084; Ncstrn_small.
DR InterPro; IPR008710; Nicastrin.
DR PANTHER; PTHR21092; NICASTRIN; 1.
DR PANTHER; PTHR21092:SF0; NICASTRIN; 1.
DR Pfam; PF18266; Ncstrn_small; 1.
DR Pfam; PF05450; Nicastrin; 1.
DR SUPFAM; SSF53187; Zn-dependent exopeptidases; 1.
PE 3: Inferred from homology;
KW Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Notch signaling pathway {ECO:0000256|ARBA:ARBA00022976};
KW Reference proteome {ECO:0000313|Proteomes:UP000000226};
KW Signal {ECO:0000256|ARBA:ARBA00022729, ECO:0000256|SAM:SignalP};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT SIGNAL 1..23
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 24..669
FT /note="Nicastrin"
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5004756424"
FT TRANSMEM 639..662
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 46..203
FT /note="Nicastrin small lobe"
FT /evidence="ECO:0000259|Pfam:PF18266"
SQ SEQUENCE 669 AA; 72638 MW; F95ADDD2355F4F5F CRC64;
MALLVLSLCL LLFTFHLPFR SSGQSSSMES VPDLQNTMYA SIEGYPCVRL LNLSGNIGCS
NPGRDKVVAP IVRFENVDKI AEPSAILVSL EEFPILFTRI SDDSRFASKV SGVLVEPSTD
LQNKLNGFSP DQKFPQGQFA PYHNTGYEWN PIGSGIMWKS YSFPVFLLTE SGSKTLKEFV
TKNEDKKKAY TSNVAEFDLV MQTVKSGTLD SKSCLKEETC LPLGGYSVWS SLPPINTSSL
QQSKPILLTV ASMDSASFFR DKSLGADSPI SGLIALLAAV DALSHLDGLG DLSKQLVFAV
FTGEAWGYLG SRRFLVELDL HSDAVHGLNQ GLIESVIEIG SVGKGLSEGV NKFFAHTEGD
SSATNQTLAA LKRAQESLLS ENVKIASASS SNPGIPPSSL MSFLEKNPAI SGVVLEDFDS
VFVNKFYHSH LDDLSNVNSS AVVAAASLVA RTLYILASEI EDVQDPTLAA INVNVSLVEQ
LMGCLLDCDP GLSCELVKKY ISPLSTCPSH YVGVILDEPS STPYTGYIND VPRFIWNFLA
DRTSIPRETN SSGCQHGCNG KDEVCIKVET DGKGVCALST TRYVPAYSTR LKFESGVWNV
LSPNSSEKMG IVDPVWTESN WNSIGMRVYT VQNAAYDRFV LFGGITLTVF SYLAIATART
FFSKAMKRD
//
