ID   V7JKU2_MYCAV            Unreviewed;       656 AA.
AC   V7JKU2;
DT   19-FEB-2014, integrated into UniProtKB/TrEMBL.
DT   19-FEB-2014, sequence version 1.
DT   24-JAN-2024, entry version 31.
DE   SubName: Full=2-oxoglutarate ferredoxin oxidoreductase subunit alpha {ECO:0000313|EMBL:ETA98945.1};
GN   ORFNames=O982_08550 {ECO:0000313|EMBL:ETA98945.1};
OS   Mycobacterium avium 10-5581.
OC   Bacteria; Actinomycetota; Actinomycetes; Mycobacteriales; Mycobacteriaceae;
OC   Mycobacterium; Mycobacterium avium complex (MAC).
OX   NCBI_TaxID=1392000 {ECO:0000313|EMBL:ETA98945.1, ECO:0000313|Proteomes:UP000018557};
RN   [1] {ECO:0000313|EMBL:ETA98945.1, ECO:0000313|Proteomes:UP000018557}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=10-5581 {ECO:0000313|EMBL:ETA98945.1,
RC   ECO:0000313|Proteomes:UP000018557};
RA   Bannantine J.P., Robbe-Austerman S., O'Connell C.;
RT   "Genome sequence of MAC strains.";
RL   Submitted (OCT-2013) to the EMBL/GenBank/DDBJ databases.
CC   -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC       whole genome shotgun (WGS) entry which is preliminary data.
CC       {ECO:0000313|EMBL:ETA98945.1}.
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DR   EMBL; AYNT01000090; ETA98945.1; -; Genomic_DNA.
DR   AlphaFoldDB; V7JKU2; -.
DR   PATRIC; fig|1392000.4.peg.1816; -.
DR   Proteomes; UP000018557; Unassembled WGS sequence.
DR   GO; GO:0000287; F:magnesium ion binding; IEA:UniProt.
DR   GO; GO:0016903; F:oxidoreductase activity, acting on the aldehyde or oxo group of donors; IEA:InterPro.
DR   CDD; cd07034; TPP_PYR_PFOR_IOR-alpha_like; 1.
DR   Gene3D; 3.40.50.920; -; 1.
DR   Gene3D; 3.40.50.970; -; 1.
DR   Gene3D; 3.40.920.10; Pyruvate-ferredoxin oxidoreductase, PFOR, domain III; 1.
DR   InterPro; IPR022367; 2-oxoacid/accept_OxRdtase_asu.
DR   InterPro; IPR033412; PFOR_II.
DR   InterPro; IPR019752; Pyrv/ketoisovalerate_OxRed_cat.
DR   InterPro; IPR002880; Pyrv_Fd/Flavodoxin_OxRdtase_N.
DR   InterPro; IPR002869; Pyrv_flavodox_OxRed_cen.
DR   InterPro; IPR029061; THDP-binding.
DR   InterPro; IPR009014; Transketo_C/PFOR_II.
DR   NCBIfam; TIGR03710; OAFO_sf; 1.
DR   PANTHER; PTHR32154:SF20; 2-OXOGLUTARATE OXIDOREDUCTASE SUBUNIT KORA; 1.
DR   PANTHER; PTHR32154; PYRUVATE-FLAVODOXIN OXIDOREDUCTASE-RELATED; 1.
DR   Pfam; PF17147; PFOR_II; 1.
DR   Pfam; PF01558; POR; 1.
DR   Pfam; PF01855; POR_N; 1.
DR   SUPFAM; SSF53323; Pyruvate-ferredoxin oxidoreductase, PFOR, domain III; 1.
DR   SUPFAM; SSF52518; Thiamin diphosphate-binding fold (THDP-binding); 1.
DR   SUPFAM; SSF52922; TK C-terminal domain-like; 1.
PE   4: Predicted;
KW   Oxidoreductase {ECO:0000256|ARBA:ARBA00023002}.
FT   DOMAIN          43..230
FT                   /note="Pyruvate/ketoisovalerate oxidoreductase catalytic"
FT                   /evidence="ECO:0000259|Pfam:PF01558"
FT   DOMAIN          279..491
FT                   /note="Pyruvate flavodoxin/ferredoxin oxidoreductase
FT                   pyrimidine binding"
FT                   /evidence="ECO:0000259|Pfam:PF01855"
FT   DOMAIN          531..616
FT                   /note="Pyruvate:ferredoxin oxidoreductase core"
FT                   /evidence="ECO:0000259|Pfam:PF17147"
FT   REGION          1..30
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        10..30
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   656 AA;  69390 MW;  84D4FF460041E1FD CRC64;
     MEGNDVDPNG SGAGSDSQNG ASPNGSSRQR LEQVVIRFAG DSGDGMQLTG DRFTSEAALF
     GNDLATQPNY PAEIRAPAGT LPGVSSFQIQ IADYDILTAG DRPDVLVAMN PAALKANIGD
     LPRGGMVIAN SDEFTKRNLT KVGYVTNPLE TDELSDYVVH SVAMTTLTLG AVESIGASKK
     DGQRAKNMFA LGLLSWMYGR PIETSEKFIR EKFARKPEVA ETNVLALKAG WNYGETTEAF
     GTTYEVSRAT LPAGEYRQIS GNTALAYGIV AAGQLADIPV VLGSYPITPA SDILHELSKH
     KNFNVITFQA EDEIGGICAA IGASYGGALG VTTTSGPGIS LKSEALGLAV MTELPLLVVD
     VQRGGPSTGL PTKTEQADLL QALFGRNGES PVAVLAPRSP SDCFETALEA ARIAVSYHTP
     VIVLSDGAIA NGSEPWRIPD VSTLPRITHA FAKPDEPFQP YARDPETLAR QFAVPGTPGL
     EHRIGGLEAA NGSGNISYEP VNHDLMVRLR QAKIDGISVP DLEVDDPTGD AELLLIGWGS
     SYGPIGEACR RARRKGIKVA HAHLRYLNPF PANLGEVLRR YPQVVCPEMN LGQLALLLRG
     KYLVDVQSVS KVQGVAFLAD EIGRVIRAAL GGTLAEVEND KTMVARMAAA TVGASA
//