ID V7JTH2_MYCAV Unreviewed; 616 AA.
AC V7JTH2;
DT 19-FEB-2014, integrated into UniProtKB/TrEMBL.
DT 19-FEB-2014, sequence version 1.
DT 27-MAR-2024, entry version 37.
DE RecName: Full=protein-glutamate O-methyltransferase {ECO:0000256|ARBA:ARBA00012534};
DE EC=2.1.1.80 {ECO:0000256|ARBA:ARBA00012534};
GN ORFNames=O982_03490 {ECO:0000313|EMBL:ETB00558.1};
OS Mycobacterium avium 10-5581.
OC Bacteria; Actinomycetota; Actinomycetes; Mycobacteriales; Mycobacteriaceae;
OC Mycobacterium; Mycobacterium avium complex (MAC).
OX NCBI_TaxID=1392000 {ECO:0000313|EMBL:ETB00558.1, ECO:0000313|Proteomes:UP000018557};
RN [1] {ECO:0000313|EMBL:ETB00558.1, ECO:0000313|Proteomes:UP000018557}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=10-5581 {ECO:0000313|EMBL:ETB00558.1,
RC ECO:0000313|Proteomes:UP000018557};
RA Bannantine J.P., Robbe-Austerman S., O'Connell C.;
RT "Genome sequence of MAC strains.";
RL Submitted (OCT-2013) to the EMBL/GenBank/DDBJ databases.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=L-glutamyl-[protein] + S-adenosyl-L-methionine = [protein]-L-
CC glutamate 5-O-methyl ester + S-adenosyl-L-homocysteine;
CC Xref=Rhea:RHEA:24452, Rhea:RHEA-COMP:10208, Rhea:RHEA-COMP:10311,
CC ChEBI:CHEBI:29973, ChEBI:CHEBI:57856, ChEBI:CHEBI:59789,
CC ChEBI:CHEBI:82795; EC=2.1.1.80;
CC Evidence={ECO:0000256|ARBA:ARBA00001541};
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:ETB00558.1}.
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DR EMBL; AYNT01000043; ETB00558.1; -; Genomic_DNA.
DR AlphaFoldDB; V7JTH2; -.
DR PATRIC; fig|1392000.4.peg.750; -.
DR Proteomes; UP000018557; Unassembled WGS sequence.
DR GO; GO:0008983; F:protein-glutamate O-methyltransferase activity; IEA:UniProtKB-EC.
DR GO; GO:0032259; P:methylation; IEA:UniProtKB-KW.
DR GO; GO:0006355; P:regulation of DNA-templated transcription; IEA:InterPro.
DR CDD; cd02440; AdoMet_MTases; 1.
DR CDD; cd00130; PAS; 2.
DR Gene3D; 1.10.155.10; Chemotaxis receptor methyltransferase CheR, N-terminal domain; 1.
DR Gene3D; 1.10.287.620; Helix Hairpins; 1.
DR Gene3D; 3.30.450.20; PAS domain; 2.
DR Gene3D; 3.40.50.150; Vaccinia Virus protein VP39; 1.
DR InterPro; IPR022642; CheR_C.
DR InterPro; IPR000780; CheR_MeTrfase.
DR InterPro; IPR022641; CheR_N.
DR InterPro; IPR036804; CheR_N_sf.
DR InterPro; IPR000014; PAS.
DR InterPro; IPR035965; PAS-like_dom_sf.
DR InterPro; IPR013767; PAS_fold.
DR InterPro; IPR029063; SAM-dependent_MTases_sf.
DR NCBIfam; TIGR00229; sensory_box; 2.
DR PANTHER; PTHR24422; CHEMOTAXIS PROTEIN METHYLTRANSFERASE; 1.
DR PANTHER; PTHR24422:SF25; CHEMOTAXIS PROTEIN METHYLTRANSFERASE; 1.
DR Pfam; PF01739; CheR; 1.
DR Pfam; PF03705; CheR_N; 1.
DR Pfam; PF00989; PAS; 1.
DR Pfam; PF13426; PAS_9; 1.
DR PRINTS; PR00996; CHERMTFRASE.
DR SMART; SM00138; MeTrc; 1.
DR SMART; SM00091; PAS; 2.
DR SUPFAM; SSF47757; Chemotaxis receptor methyltransferase CheR, N-terminal domain; 1.
DR SUPFAM; SSF55785; PYP-like sensor domain (PAS domain); 2.
DR SUPFAM; SSF53335; S-adenosyl-L-methionine-dependent methyltransferases; 1.
DR PROSITE; PS50123; CHER; 1.
DR PROSITE; PS50112; PAS; 1.
PE 4: Predicted;
KW Coiled coil {ECO:0000256|SAM:Coils};
KW Methyltransferase {ECO:0000256|ARBA:ARBA00022603};
KW S-adenosyl-L-methionine {ECO:0000256|ARBA:ARBA00022691};
KW Transferase {ECO:0000256|ARBA:ARBA00022679}.
FT DOMAIN 1..270
FT /note="CheR-type methyltransferase"
FT /evidence="ECO:0000259|PROSITE:PS50123"
FT DOMAIN 501..545
FT /note="PAS"
FT /evidence="ECO:0000259|PROSITE:PS50112"
FT COILED 418..494
FT /evidence="ECO:0000256|SAM:Coils"
SQ SEQUENCE 616 AA; 69181 MW; 27F8C7BE98B35D11 CRC64;
MNSTTDEADE AFEALLRYMR DSRGFDFTGY KRTSLMRRVR HRMDQAGYTA FDEYLDFLQA
SSDEFTALFN TILINVTSFF RDPDAWEFVA AEVIPRLLAE RGPNDPIRVW SAGCASGQEA
YTLAMLLAEA LGFDAFRQRV KIYATDVDED ALTEARGASY DARAVESVPA DLLARYFEQV
NGRYVFHKDL RRAVIFGRND LVKDAPISRV DLLVCRNTLM YLNAETQRNV LGRLHFALAP
QGTLFLGHAE MLLSHGDRFT PLSLKHRIFR KAVGSHSGLD HYDPAGAFYE RHADLPGLAT
VRDLAFRASP VAQIVVTGED TVAMINQQAE TVFGLSARDI GRLLRDLEVS YRPVELRAYL
EQAKVERRSA RIQDVKWQRP GAETVWFEIH VNPLVDAENG LLGVSIVFFD VTATRALLDK
VVQTNRQLEA AYEELQSTNE ELETTNEELQ STVEELETTN EELQSTNEEL ETMNEELQST
NDELHTINDM LRERSLELDD AKSFLDSLVD SVRMGMVVVD REMKVILWNR GCEELWGLRA
DETTGTMLTA LDIGLPLDAV RPLIGNAFVD PDGSGEVVVD AVNRRGRPAR VRVTCTSFRG
NEGTVGGALL LMDVVG
//
