ID V7PWH4_9BACT Unreviewed; 746 AA.
AC V7PWH4;
DT 19-FEB-2014, integrated into UniProtKB/TrEMBL.
DT 19-FEB-2014, sequence version 1.
DT 13-SEP-2023, entry version 47.
DE RecName: Full=HMA domain-containing protein {ECO:0000259|PROSITE:PS50846};
GN ORFNames=O210_OD1C00001G0447 {ECO:0000313|EMBL:ETB63969.1};
OS Parcubacteria bacterium RAAC4_OD1_1.
OC Bacteria; Candidatus Parcubacteria.
OX NCBI_TaxID=1394712 {ECO:0000313|EMBL:ETB63969.1, ECO:0000313|Proteomes:UP000018547};
RN [1] {ECO:0000313|EMBL:ETB63969.1, ECO:0000313|Proteomes:UP000018547}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Kantor R.S., Wrighton K.C., Handley K.M., Sharon I., Hug L.A.,
RA Castelle C.J., Thomas B.C., Banfield J.F.;
RT "Small genomes and sparse metabolisms of sediment-associated bacteria from
RT four candidate phyla.";
RL Submitted (NOV-2013) to the EMBL/GenBank/DDBJ databases.
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000256|RuleBase:RU362081}.
CC -!- SIMILARITY: Belongs to the cation transport ATPase (P-type) (TC 3.A.3)
CC family. Type IB subfamily. {ECO:0000256|ARBA:ARBA00006024,
CC ECO:0000256|RuleBase:RU362081}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:ETB63969.1}.
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DR EMBL; AWSN01000001; ETB63969.1; -; Genomic_DNA.
DR AlphaFoldDB; V7PWH4; -.
DR STRING; 1394712.O210_OD1C00001G0447; -.
DR PATRIC; fig|1394712.3.peg.419; -.
DR Proteomes; UP000018547; Unassembled WGS sequence.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR GO; GO:0016887; F:ATP hydrolysis activity; IEA:InterPro.
DR GO; GO:0019829; F:ATPase-coupled monoatomic cation transmembrane transporter activity; IEA:InterPro.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR CDD; cd00371; HMA; 1.
DR CDD; cd02094; P-type_ATPase_Cu-like; 1.
DR Gene3D; 3.30.70.100; -; 1.
DR Gene3D; 3.40.1110.10; Calcium-transporting ATPase, cytoplasmic domain N; 1.
DR Gene3D; 2.70.150.10; Calcium-transporting ATPase, cytoplasmic transduction domain A; 1.
DR Gene3D; 3.40.50.1000; HAD superfamily/HAD-like; 1.
DR InterPro; IPR023299; ATPase_P-typ_cyto_dom_N.
DR InterPro; IPR018303; ATPase_P-typ_P_site.
DR InterPro; IPR023298; ATPase_P-typ_TM_dom_sf.
DR InterPro; IPR008250; ATPase_P-typ_transduc_dom_A_sf.
DR InterPro; IPR036412; HAD-like_sf.
DR InterPro; IPR023214; HAD_sf.
DR InterPro; IPR017969; Heavy-metal-associated_CS.
DR InterPro; IPR006121; HMA_dom.
DR InterPro; IPR036163; HMA_dom_sf.
DR InterPro; IPR027256; P-typ_ATPase_IB.
DR InterPro; IPR001757; P_typ_ATPase.
DR InterPro; IPR044492; P_typ_ATPase_HD_dom.
DR NCBIfam; TIGR01511; ATPase-IB1_Cu; 1.
DR NCBIfam; TIGR01512; ATPase-IB2_Cd; 1.
DR NCBIfam; TIGR01525; ATPase-IB_hvy; 1.
DR NCBIfam; TIGR01494; ATPase_P-type; 1.
DR PANTHER; PTHR43520; ATP7, ISOFORM B; 1.
DR PANTHER; PTHR43520:SF8; COPPER-TRANSPORTING ATPASE 2; 1.
DR Pfam; PF00122; E1-E2_ATPase; 1.
DR Pfam; PF00403; HMA; 1.
DR Pfam; PF00702; Hydrolase; 1.
DR PRINTS; PR00119; CATATPASE.
DR PRINTS; PR00943; CUATPASE.
DR SFLD; SFLDS00003; Haloacid_Dehalogenase; 1.
DR SFLD; SFLDF00027; p-type_atpase; 1.
DR SUPFAM; SSF81653; Calcium ATPase, transduction domain A; 1.
DR SUPFAM; SSF81665; Calcium ATPase, transmembrane domain M; 1.
DR SUPFAM; SSF56784; HAD-like; 1.
DR SUPFAM; SSF55008; HMA, heavy metal-associated domain; 1.
DR PROSITE; PS00154; ATPASE_E1_E2; 1.
DR PROSITE; PS01047; HMA_1; 1.
DR PROSITE; PS50846; HMA_2; 1.
PE 3: Inferred from homology;
KW ATP-binding {ECO:0000256|RuleBase:RU362081};
KW Cell membrane {ECO:0000256|RuleBase:RU362081};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|RuleBase:RU362081};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723,
KW ECO:0000256|RuleBase:RU362081};
KW Nucleotide-binding {ECO:0000256|RuleBase:RU362081};
KW Reference proteome {ECO:0000313|Proteomes:UP000018547};
KW Translocase {ECO:0000256|ARBA:ARBA00022967};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692,
KW ECO:0000256|RuleBase:RU362081};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|RuleBase:RU362081}.
FT TRANSMEM 96..113
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU362081"
FT TRANSMEM 125..145
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU362081"
FT TRANSMEM 166..185
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU362081"
FT TRANSMEM 197..216
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU362081"
FT TRANSMEM 353..377
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU362081"
FT TRANSMEM 383..406
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU362081"
FT TRANSMEM 692..715
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU362081"
FT TRANSMEM 721..739
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU362081"
FT DOMAIN 2..68
FT /note="HMA"
FT /evidence="ECO:0000259|PROSITE:PS50846"
SQ SEQUENCE 746 AA; 81124 MW; 2DFA5F18BEAB5EAF CRC64;
MKNKIFKIEG MHCASCATII SKEVSKLPGI NKVNVNFANE KAKIDFDENK TNLEIMNSSI
EKLGYHIVDQ EGSTPYNQMK TKSDIEEINN KSKTKFIMPI SIIVFFIMMW DILAKTSSLV
PNIPIPMELL NTIMMIISTI VLFYIGKPFL KGVTRFIRYG KANMDTLIGI GTLTAYIYSS
IITLFPQVNM AMNLPDYTYF DVVIVVIGFI TFGKYLESRS KKKTGEAIEK LIKLGAKTAI
VKRDGKEIEI EVSEVKVGDM IIVKPGMKIP VDGKITEGTT SIDESMITGE SMPVDKKVGD
IVTGATINKQ GSIVFEATKV GEETVLSSII KMVENAQGSK APIEALADRV SNIFVPTVLI
VAFITLILWM IIGIPILGKS IAISYGLLSF VGILVIACPC ALGLATPTAI IVGVGKGAEH
GILIKDAESL EKLSKVDTIV LDKTGTITKG KPEVTNIVSL DSIYKETDII KITASLEALS
EHPLGLAIKN YALSQNIILN KVDDFAALEG IGVKGKIKDL NVFIHKPEDK DINEELRELQ
NEGKTVIIIE VENKKIGLMA LSDTIKDNAK ETINKLHKKG IKVIMLTGDN HLAAKYIADQ
VNIDNVYSEV LPKDKIDKII SLQKEGRIVA MAGDGINDAP ALTEADVGIA MATGSDIAIE
SAGITLLNGD IHKLSEAIIL SKKTFATVKQ NLFWAFIYNV IGIPIAAGIL FPIWGIILNP
IFAGLAMALS SVSVVGNSLR LKVKKI
//
