ID V8NDA5_OPHHA Unreviewed; 562 AA.
AC V8NDA5;
DT 19-FEB-2014, integrated into UniProtKB/TrEMBL.
DT 19-FEB-2014, sequence version 1.
DT 24-JAN-2024, entry version 31.
DE SubName: Full=VPS10 domain-containing receptor SorCS1 {ECO:0000313|EMBL:ETE60259.1};
DE Flags: Fragment;
GN Name=Sorcs1 {ECO:0000313|EMBL:ETE60259.1};
GN ORFNames=L345_13999 {ECO:0000313|EMBL:ETE60259.1};
OS Ophiophagus hannah (King cobra) (Naja hannah).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Lepidosauria; Squamata; Bifurcata; Unidentata; Episquamata; Toxicofera;
OC Serpentes; Colubroidea; Elapidae; Elapinae; Ophiophagus.
OX NCBI_TaxID=8665 {ECO:0000313|EMBL:ETE60259.1, ECO:0000313|Proteomes:UP000018936};
RN [1] {ECO:0000313|EMBL:ETE60259.1, ECO:0000313|Proteomes:UP000018936}
RP NUCLEOTIDE SEQUENCE.
RC TISSUE=Blood {ECO:0000313|EMBL:ETE60259.1};
RX PubMed=24297900; DOI=10.1073/pnas.1314702110;
RA Vonk F.J., Casewell N.R., Henkel C.V., Heimberg A.M., Jansen H.J.,
RA McCleary R.J., Kerkkamp H.M., Vos R.A., Guerreiro I., Calvete J.J.,
RA Wuster W., Woods A.E., Logan J.M., Harrison R.A., Castoe T.A.,
RA de Koning A.P., Pollock D.D., Yandell M., Calderon D., Renjifo C.,
RA Currier R.B., Salgado D., Pla D., Sanz L., Hyder A.S., Ribeiro J.M.,
RA Arntzen J.W., van den Thillart G.E., Boetzer M., Pirovano W., Dirks R.P.,
RA Spaink H.P., Duboule D., McGlinn E., Kini R.M., Richardson M.K.;
RT "The king cobra genome reveals dynamic gene evolution and adaptation in the
RT snake venom system.";
RL Proc. Natl. Acad. Sci. U.S.A. 110:20651-20656(2013).
CC -!- SIMILARITY: Belongs to the VPS10-related sortilin family. SORCS
CC subfamily. {ECO:0000256|ARBA:ARBA00010818}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:ETE60259.1}.
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DR EMBL; AZIM01004822; ETE60259.1; -; Genomic_DNA.
DR AlphaFoldDB; V8NDA5; -.
DR Proteomes; UP000018936; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:InterPro.
DR CDD; cd15482; Sialidase_non-viral; 1.
DR Gene3D; 2.10.70.80; -; 1.
DR Gene3D; 2.120.10.10; -; 1.
DR Gene3D; 3.30.60.270; -; 1.
DR Gene3D; 2.60.40.10; Immunoglobulins; 1.
DR InterPro; IPR013783; Ig-like_fold.
DR InterPro; IPR000601; PKD_dom.
DR InterPro; IPR035986; PKD_dom_sf.
DR InterPro; IPR031777; Sortilin_C.
DR InterPro; IPR031778; Sortilin_N.
DR InterPro; IPR006581; VPS10.
DR PANTHER; PTHR12106; SORTILIN RELATED; 1.
DR PANTHER; PTHR12106:SF8; VPS10 DOMAIN-CONTAINING RECEPTOR SORCS1; 1.
DR Pfam; PF00801; PKD; 1.
DR Pfam; PF15902; Sortilin-Vps10; 1.
DR Pfam; PF15901; Sortilin_C; 1.
DR SMART; SM00602; VPS10; 1.
DR SUPFAM; SSF110296; Oligoxyloglucan reducing end-specific cellobiohydrolase; 1.
DR SUPFAM; SSF49299; PKD domain; 1.
DR PROSITE; PS50093; PKD; 1.
PE 3: Inferred from homology;
KW Receptor {ECO:0000313|EMBL:ETE60259.1};
KW Reference proteome {ECO:0000313|Proteomes:UP000018936};
KW Repeat {ECO:0000256|ARBA:ARBA00022737}.
FT DOMAIN 462..506
FT /note="PKD"
FT /evidence="ECO:0000259|PROSITE:PS50093"
FT NON_TER 1
FT /evidence="ECO:0000313|EMBL:ETE60259.1"
SQ SEQUENCE 562 AA; 63334 MW; 538616EE26877EC1 CRC64;
MQNCSEAVRS KPFPGYIDSD SLIVQDDYVF VQLTSGGRPH YYVSYRRNTF AQMKLPKYAL
PKDMHVISTD ENQVFAAVQE WNQNDTYNLY ISDTQGIYFT LALENVKSSR DLEGNVMIDL
YEVAGIKGMF LANKKIDNQV KTFITYNKGR DWHLLQAPDT DLRGNPVHCL LPYCSLHLHL
KVSENPYTSG NIASRDTAPG IIVASGNIGS ELSENDISMF VSSDAGNTWR QIFEDEHSVL
YLDQGGVLVA MKHTSLPIRH LWLSFDEGRS WSNVFGHFSH RSEWQLVKVD YKSIFDRRCA
EDDYQPWQLH SQGEACIMGA KRTYKKRKSE KKCMQGKYAG AMSSEPCVCT EADFDCDYGF
ERHSNGQCLP AFWYNPSSLS KECSLGQSYL NSTGYRKVVS NNCTDGVRER YTAKSQQCPG
KAPRGLRVVT SDGTLTSEQG HNVTFMVQLE EGDIQRSIIR VDFGDGSAVS YANLSSTEDG
IRHIYQNVGI FRVTAQIKNS LGTDTAVLYL HHVHLSLPFV TTKNKEVNAT AILWPSQVGT
LTYIWWFGNN TEVCISCSKV NG
//
