ID V8NDR9_OPHHA Unreviewed; 1444 AA.
AC V8NDR9;
DT 19-FEB-2014, integrated into UniProtKB/TrEMBL.
DT 19-FEB-2014, sequence version 1.
DT 27-MAR-2024, entry version 31.
DE RecName: Full=ribonuclease H {ECO:0000256|ARBA:ARBA00012180};
DE EC=3.1.26.4 {ECO:0000256|ARBA:ARBA00012180};
DE Flags: Fragment;
GN Name=PEG10 {ECO:0000313|EMBL:ETE60414.1};
GN ORFNames=L345_13844 {ECO:0000313|EMBL:ETE60414.1};
OS Ophiophagus hannah (King cobra) (Naja hannah).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Lepidosauria; Squamata; Bifurcata; Unidentata; Episquamata; Toxicofera;
OC Serpentes; Colubroidea; Elapidae; Elapinae; Ophiophagus.
OX NCBI_TaxID=8665 {ECO:0000313|EMBL:ETE60414.1, ECO:0000313|Proteomes:UP000018936};
RN [1] {ECO:0000313|EMBL:ETE60414.1, ECO:0000313|Proteomes:UP000018936}
RP NUCLEOTIDE SEQUENCE.
RC TISSUE=Blood {ECO:0000313|EMBL:ETE60414.1};
RX PubMed=24297900; DOI=10.1073/pnas.1314702110;
RA Vonk F.J., Casewell N.R., Henkel C.V., Heimberg A.M., Jansen H.J.,
RA McCleary R.J., Kerkkamp H.M., Vos R.A., Guerreiro I., Calvete J.J.,
RA Wuster W., Woods A.E., Logan J.M., Harrison R.A., Castoe T.A.,
RA de Koning A.P., Pollock D.D., Yandell M., Calderon D., Renjifo C.,
RA Currier R.B., Salgado D., Pla D., Sanz L., Hyder A.S., Ribeiro J.M.,
RA Arntzen J.W., van den Thillart G.E., Boetzer M., Pirovano W., Dirks R.P.,
RA Spaink H.P., Duboule D., McGlinn E., Kini R.M., Richardson M.K.;
RT "The king cobra genome reveals dynamic gene evolution and adaptation in the
RT snake venom system.";
RL Proc. Natl. Acad. Sci. U.S.A. 110:20651-20656(2013).
CC -!- SIMILARITY: Belongs to the beta type-B retroviral polymerase family.
CC HERV class-II K(HML-2) pol subfamily. {ECO:0000256|ARBA:ARBA00010879}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:ETE60414.1}.
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DR EMBL; AZIM01004693; ETE60414.1; -; Genomic_DNA.
DR Proteomes; UP000018936; Unassembled WGS sequence.
DR GO; GO:0003676; F:nucleic acid binding; IEA:InterPro.
DR GO; GO:0008270; F:zinc ion binding; IEA:InterPro.
DR GO; GO:0015074; P:DNA integration; IEA:InterPro.
DR CDD; cd00303; retropepsin_like; 1.
DR CDD; cd09274; RNase_HI_RT_Ty3; 1.
DR CDD; cd01647; RT_LTR; 1.
DR Gene3D; 3.30.70.270; -; 2.
DR Gene3D; 2.40.70.10; Acid Proteases; 1.
DR Gene3D; 3.10.10.10; HIV Type 1 Reverse Transcriptase, subunit A, domain 1; 1.
DR Gene3D; 3.30.420.10; Ribonuclease H-like superfamily/Ribonuclease H; 1.
DR InterPro; IPR043502; DNA/RNA_pol_sf.
DR InterPro; IPR032549; DUF4939.
DR InterPro; IPR001584; Integrase_cat-core.
DR InterPro; IPR021109; Peptidase_aspartic_dom_sf.
DR InterPro; IPR043128; Rev_trsase/Diguanyl_cyclase.
DR InterPro; IPR012337; RNaseH-like_sf.
DR InterPro; IPR036397; RNaseH_sf.
DR InterPro; IPR000477; RT_dom.
DR InterPro; IPR041577; RT_RNaseH_2.
DR InterPro; IPR036875; Znf_CCHC_sf.
DR PANTHER; PTHR24559:SF437; RIBONUCLEASE H; 1.
DR PANTHER; PTHR24559; TRANSPOSON TY3-I GAG-POL POLYPROTEIN; 1.
DR Pfam; PF16297; DUF4939; 1.
DR Pfam; PF17919; RT_RNaseH_2; 1.
DR Pfam; PF08284; RVP_2; 1.
DR Pfam; PF00078; RVT_1; 1.
DR SUPFAM; SSF56672; DNA/RNA polymerases; 1.
DR SUPFAM; SSF57756; Retrovirus zinc finger-like domains; 1.
DR SUPFAM; SSF53098; Ribonuclease H-like; 1.
DR PROSITE; PS50994; INTEGRASE; 1.
PE 3: Inferred from homology;
KW Reference proteome {ECO:0000313|Proteomes:UP000018936}.
FT DOMAIN 1036..1193
FT /note="Integrase catalytic"
FT /evidence="ECO:0000259|PROSITE:PS50994"
FT REGION 39..97
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 83..97
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT NON_TER 1
FT /evidence="ECO:0000313|EMBL:ETE60414.1"
SQ SEQUENCE 1444 AA; 162247 MW; D56AC4C2E18D7267 CRC64;
MLRVPGFYTI SGFKLPRAQE EYPDWLLSEI IASFQMRMAE VSESEDSDEG PACDAGLGPG
PSGSGMLPLE IVEAGSSDEE APEEPVPSTH ACRADQRKEQ LKQHGKCPVA VPDKFTSKQA
MFPAVLGQCQ LFISLRAEDF PTDWDKVGFV ISLLSGSAAR WATPLLHPAH TFSHWVAAMN
HDSGFCDHLH LMYEDPIKTQ AAARHLKDLQ QGQESQDSAW NEAALMDTLQ DGLSDKLQDE
LAWVDCPMTL NMLIHLCLRI DACLQRDSCG PCGVETPAPQ EEAMDLGATR PCLSVTEHNR
RRAKGLCLYC RELGYLAASC PKKQREALAL VSSVSVPDSQ TQTTLSGNGR TDMDSGPPRH
LILVVQGFLA NSSQGIPVHA LVDSGTTTNF MDMAFATQYE VPQCPVVPPL LVETIDGRVL
LSGPIRAATQ PFHLTISSHE EAIQFYITSR LHFPMVLGVA WLQSHDPQIY WSQNLITFLS
LQCTDHTHQV CARQVMTLPE VSVPSEHTDF ADIFSEQEVG QLLPHQPYDC SIDLVPDAAL
PVGHLYSMSD MELATLWDFL DKNLARSFIR PSSSPLSAPV LFVKKKMGDL HLCCDYRQFN
AITQLREATV FMKLDLHGAY NLVWIWPRDE WKTAFGTRYG HFEYTVMPFG LTNAPTVFQH
FINDIFWDLL DQFVVVYLND ILIYSNLRDS HLHHLHLVLQ WLWENCLYAK LEKCQFFQST
IKCLGHCISL EGISMELSKD VQQFLRFANY YSTFIPGFTS LTAPLTWFLQ KKVPFWWGAP
EQQVFQALKQ AFMNEPILKH AVPHHPFVVE ADASNVAVGA MLLKAHASGG ILFPCAYYSR
KLNPAKHNWE KELLVIKAGF EAWKHHLEGA CHQVEVQTVH KNLEFLKTAQ KLNQHQIWWY
VFFAHFNFHV TYIPSGRNQW ADALSWKPEN LCPEDQPPLW TVLPVESFSI MQEPVDLRAQ
IRETQRHNTW ADQQKTRGGI QLAMIVHGGT LALFRALRPL QDIASHVSDF LVALTTTRCV
VLCYVLCAML AGQVGGCSSP CRHQRDLGIC PPSSGFTTVF VVIDMLTKMA HFIPCCGLPM
ARATTGMFIQ HIFWIHGLPN RMVSDRGMQF TAQFWKGLMM ALDIKICLLS SHHLETEGRM
EKVIGILEQY LRFFFAFNNS QHTSMQITPF LTNVGYHPWF FPLTPLDSLV LEVKNFLSEL
QAVHQLVQHY LQKAKDDFNN TTIGCGGSGV VVYLAPSVRS AGEEARPSIP WYIPCRGSNQ
LSHLLPDFAL LAMGPSSFHR SLLVPEQLVC LLLQPAPALP TRGDSNTLSN GRAMDQKHSL
GRMRCLSMSW LWWKSFTQNS RCSCIWTVRH GERALCRCGW LRSWRARTQM REPACDAGMG
PGPSGSGMLP LELWRLAAVM KRPLRSPCPV RMRAGLLKGK SSCSSMGDSG PAEKLKFFAE
GKEV
//
