ID V8NKF8_OPHHA Unreviewed; 692 AA.
AC V8NKF8;
DT 19-FEB-2014, integrated into UniProtKB/TrEMBL.
DT 19-FEB-2014, sequence version 1.
DT 27-MAR-2024, entry version 36.
DE RecName: Full=F-box/LRR-repeat protein 5 {ECO:0000256|ARBA:ARBA00020540};
DE AltName: Full=F-box and leucine-rich repeat protein 5 {ECO:0000256|ARBA:ARBA00030695};
GN Name=FBXL5 {ECO:0000313|EMBL:ETE62158.1};
GN ORFNames=L345_12087 {ECO:0000313|EMBL:ETE62158.1};
OS Ophiophagus hannah (King cobra) (Naja hannah).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Lepidosauria; Squamata; Bifurcata; Unidentata; Episquamata; Toxicofera;
OC Serpentes; Colubroidea; Elapidae; Elapinae; Ophiophagus.
OX NCBI_TaxID=8665 {ECO:0000313|EMBL:ETE62158.1, ECO:0000313|Proteomes:UP000018936};
RN [1] {ECO:0000313|EMBL:ETE62158.1, ECO:0000313|Proteomes:UP000018936}
RP NUCLEOTIDE SEQUENCE.
RC TISSUE=Blood {ECO:0000313|EMBL:ETE62158.1};
RX PubMed=24297900; DOI=10.1073/pnas.1314702110;
RA Vonk F.J., Casewell N.R., Henkel C.V., Heimberg A.M., Jansen H.J.,
RA McCleary R.J., Kerkkamp H.M., Vos R.A., Guerreiro I., Calvete J.J.,
RA Wuster W., Woods A.E., Logan J.M., Harrison R.A., Castoe T.A.,
RA de Koning A.P., Pollock D.D., Yandell M., Calderon D., Renjifo C.,
RA Currier R.B., Salgado D., Pla D., Sanz L., Hyder A.S., Ribeiro J.M.,
RA Arntzen J.W., van den Thillart G.E., Boetzer M., Pirovano W., Dirks R.P.,
RA Spaink H.P., Duboule D., McGlinn E., Kini R.M., Richardson M.K.;
RT "The king cobra genome reveals dynamic gene evolution and adaptation in the
RT snake venom system.";
RL Proc. Natl. Acad. Sci. U.S.A. 110:20651-20656(2013).
CC -!- COFACTOR:
CC Name=[2Fe-2S] cluster; Xref=ChEBI:CHEBI:190135;
CC Evidence={ECO:0000256|ARBA:ARBA00034078};
CC -!- PATHWAY: Protein modification; protein ubiquitination.
CC {ECO:0000256|ARBA:ARBA00004906}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm, perinuclear region
CC {ECO:0000256|ARBA:ARBA00004556}. Nucleus
CC {ECO:0000256|ARBA:ARBA00004123}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:ETE62158.1}.
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DR EMBL; AZIM01003416; ETE62158.1; -; Genomic_DNA.
DR AlphaFoldDB; V8NKF8; -.
DR UniPathway; UPA00143; -.
DR Proteomes; UP000018936; Unassembled WGS sequence.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0048471; C:perinuclear region of cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0051536; F:iron-sulfur cluster binding; IEA:UniProtKB-KW.
DR GO; GO:0006879; P:intracellular iron ion homeostasis; IEA:InterPro.
DR GO; GO:0016567; P:protein ubiquitination; IEA:UniProtKB-UniPathway.
DR CDD; cd22118; F-box_FBXL5; 1.
DR CDD; cd12109; Hr_FBXL5; 1.
DR Gene3D; 1.20.1280.50; -; 1.
DR Gene3D; 1.20.120.520; nmb1532 protein domain like; 1.
DR Gene3D; 3.80.10.10; Ribonuclease Inhibitor; 2.
DR InterPro; IPR036047; F-box-like_dom_sf.
DR InterPro; IPR001810; F-box_dom.
DR InterPro; IPR012312; Hemerythrin-like.
DR InterPro; IPR045808; Hr_FBXL5.
DR InterPro; IPR001611; Leu-rich_rpt.
DR InterPro; IPR006553; Leu-rich_rpt_Cys-con_subtyp.
DR InterPro; IPR032675; LRR_dom_sf.
DR PANTHER; PTHR13382:SF7; DNA REPAIR PROTEIN RAD7; 1.
DR PANTHER; PTHR13382; MITOCHONDRIAL ATP SYNTHASE COUPLING FACTOR B; 1.
DR Pfam; PF12937; F-box-like; 1.
DR Pfam; PF01814; Hemerythrin; 1.
DR Pfam; PF13516; LRR_6; 2.
DR SMART; SM00256; FBOX; 1.
DR SMART; SM00367; LRR_CC; 4.
DR SUPFAM; SSF81383; F-box domain; 1.
DR SUPFAM; SSF52047; RNI-like; 1.
DR PROSITE; PS50181; FBOX; 1.
PE 4: Predicted;
KW Iron {ECO:0000256|ARBA:ARBA00023004};
KW Iron-sulfur {ECO:0000256|ARBA:ARBA00023014};
KW Metal-binding {ECO:0000256|ARBA:ARBA00023014};
KW Nucleus {ECO:0000256|ARBA:ARBA00023242};
KW Reference proteome {ECO:0000313|Proteomes:UP000018936};
KW Ubl conjugation {ECO:0000256|ARBA:ARBA00022843}.
FT DOMAIN 203..249
FT /note="F-box"
FT /evidence="ECO:0000259|PROSITE:PS50181"
FT REGION 286..305
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 287..303
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 692 AA; 78980 MW; 95FE574FB524434D CRC64;
MAPFPEEVDV FTAPHWRMKQ LVGLYCDKLS KTNFSNNNDF RALLQSLYAT FKEFKMHEQI
ENEYIIGLLQ QRSQTVYNVH SDNKLSEMLS LFEKGLKNVK NEYEQLNYAK QLKERLEAFT
RDFLPHMKEE EEVFQPMLME YFTYEELKDI KKKVIAQHCS QKETAAEIRR GISLWNQAEE
LQKAFKYSVD EKADHETEEP EQATSIVHLP SEVMLTIFTY LSPQELCRCS QVSSKWSQLA
KTGFLWKHLY PVHWARGNWS HGPPGDLDTE PDEEWVKNRK DESQAFQEWD EDADIDESEE
NGEESSAISI VQKEKDLLQG IIHNILPRVG SSVKTIVLAY SSAISNKMVR HILELCPNLE
YLDLTQTDIS DSAFESWSWI GCCQSLRHLD LSGCERITDM AVRKISKALG ILSSHEIQSQ
KSFQNRRGKT VWKNKEIALE FSKKECGLHY ITNENVIKEE GSHWNVPVRS EGFNSAYIWM
LDAKDLADIE DAAEWKHRKF EGDCVIEPAS PFPCSASCCN KDIFGLRTSF CWQEQQPCAS
AALTYCGHSF CCAGSALKTF QALPPSPELL NHTPRTNRQI EGKDLTHLMS AKSDQKTARV
LQFLSLSGCY QITDNGLRML ALRGGLPYLE HLNLSGCLTV TSAGLQDLVS VCPSLNHEHF
YYCDNINGPH AETASGCQNL QCGFRACCRS GE
//
