ID V8NLJ5_OPHHA Unreviewed; 731 AA.
AC V8NLJ5;
DT 19-FEB-2014, integrated into UniProtKB/TrEMBL.
DT 19-FEB-2014, sequence version 1.
DT 27-MAR-2024, entry version 40.
DE SubName: Full=Collagen alpha-1(XXVIII) chain {ECO:0000313|EMBL:ETE62935.1};
DE Flags: Fragment;
GN Name=Col28a1 {ECO:0000313|EMBL:ETE62935.1};
GN ORFNames=L345_11309 {ECO:0000313|EMBL:ETE62935.1};
OS Ophiophagus hannah (King cobra) (Naja hannah).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Lepidosauria; Squamata; Bifurcata; Unidentata; Episquamata; Toxicofera;
OC Serpentes; Colubroidea; Elapidae; Elapinae; Ophiophagus.
OX NCBI_TaxID=8665 {ECO:0000313|EMBL:ETE62935.1, ECO:0000313|Proteomes:UP000018936};
RN [1] {ECO:0000313|EMBL:ETE62935.1, ECO:0000313|Proteomes:UP000018936}
RP NUCLEOTIDE SEQUENCE.
RC TISSUE=Blood {ECO:0000313|EMBL:ETE62935.1};
RX PubMed=24297900; DOI=10.1073/pnas.1314702110;
RA Vonk F.J., Casewell N.R., Henkel C.V., Heimberg A.M., Jansen H.J.,
RA McCleary R.J., Kerkkamp H.M., Vos R.A., Guerreiro I., Calvete J.J.,
RA Wuster W., Woods A.E., Logan J.M., Harrison R.A., Castoe T.A.,
RA de Koning A.P., Pollock D.D., Yandell M., Calderon D., Renjifo C.,
RA Currier R.B., Salgado D., Pla D., Sanz L., Hyder A.S., Ribeiro J.M.,
RA Arntzen J.W., van den Thillart G.E., Boetzer M., Pirovano W., Dirks R.P.,
RA Spaink H.P., Duboule D., McGlinn E., Kini R.M., Richardson M.K.;
RT "The king cobra genome reveals dynamic gene evolution and adaptation in the
RT snake venom system.";
RL Proc. Natl. Acad. Sci. U.S.A. 110:20651-20656(2013).
CC -!- FUNCTION: Collagen VI acts as a cell-binding protein.
CC {ECO:0000256|ARBA:ARBA00043858}.
CC -!- SUBCELLULAR LOCATION: Secreted, extracellular space, extracellular
CC matrix {ECO:0000256|ARBA:ARBA00004498}.
CC -!- SIMILARITY: Belongs to the type VI collagen family.
CC {ECO:0000256|ARBA:ARBA00044000}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:ETE62935.1}.
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DR EMBL; AZIM01002986; ETE62935.1; -; Genomic_DNA.
DR AlphaFoldDB; V8NLJ5; -.
DR Proteomes; UP000018936; Unassembled WGS sequence.
DR GO; GO:0005581; C:collagen trimer; IEA:UniProtKB-KW.
DR GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR GO; GO:0004867; F:serine-type endopeptidase inhibitor activity; IEA:InterPro.
DR GO; GO:0090729; F:toxin activity; IEA:UniProtKB-KW.
DR GO; GO:0007155; P:cell adhesion; IEA:UniProtKB-KW.
DR CDD; cd22628; Kunitz_collagen_alpha1_XXVIII; 1.
DR Gene3D; 4.10.410.10; Pancreatic trypsin inhibitor Kunitz domain; 1.
DR Gene3D; 3.40.50.410; von Willebrand factor, type A domain; 1.
DR InterPro; IPR008160; Collagen.
DR InterPro; IPR002223; Kunitz_BPTI.
DR InterPro; IPR036880; Kunitz_BPTI_sf.
DR InterPro; IPR020901; Prtase_inh_Kunz-CS.
DR InterPro; IPR002035; VWF_A.
DR InterPro; IPR036465; vWFA_dom_sf.
DR PANTHER; PTHR22588:SF5; COLLAGEN ALPHA-6(VI) CHAIN; 1.
DR PANTHER; PTHR22588; UNCHARACTERIZED; 1.
DR Pfam; PF01391; Collagen; 1.
DR Pfam; PF00014; Kunitz_BPTI; 1.
DR Pfam; PF00092; VWA; 1.
DR PRINTS; PR00759; BASICPTASE.
DR PRINTS; PR00453; VWFADOMAIN.
DR SMART; SM00131; KU; 1.
DR SMART; SM00327; VWA; 1.
DR SUPFAM; SSF57362; BPTI-like; 1.
DR SUPFAM; SSF53300; vWA-like; 1.
DR PROSITE; PS00280; BPTI_KUNITZ_1; 1.
DR PROSITE; PS50279; BPTI_KUNITZ_2; 1.
DR PROSITE; PS50234; VWFA; 1.
PE 3: Inferred from homology;
KW Cell adhesion {ECO:0000256|ARBA:ARBA00022889};
KW Collagen {ECO:0000256|ARBA:ARBA00023119, ECO:0000313|EMBL:ETE62935.1};
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157};
KW Extracellular matrix {ECO:0000256|ARBA:ARBA00022530};
KW Reference proteome {ECO:0000313|Proteomes:UP000018936};
KW Secreted {ECO:0000256|ARBA:ARBA00022530};
KW Toxin {ECO:0000256|ARBA:ARBA00022656}.
FT DOMAIN 354..538
FT /note="VWFA"
FT /evidence="ECO:0000259|PROSITE:PS50234"
FT DOMAIN 595..645
FT /note="BPTI/Kunitz inhibitor"
FT /evidence="ECO:0000259|PROSITE:PS50279"
FT REGION 1..327
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT NON_TER 1
FT /evidence="ECO:0000313|EMBL:ETE62935.1"
FT NON_TER 731
FT /evidence="ECO:0000313|EMBL:ETE62935.1"
SQ SEQUENCE 731 AA; 76227 MW; 5E57E7FC8AC8141D CRC64;
GERGLPGPVG LTGETGVGLP GPKGDIGLTG RPGPPGPPGI GEPGLPGTQG PQGIQGERGS
EGEGLPGPKG DRGFEGPKGP RGQPGIGIKG EKGEIGPPGL PGPIGLPGIG IQGEKGVEGP
KGPLGPRGPP GQGLPGPKGE PGTSGLAGLP GLPGEDGAPG QKGEPGLPGP RGPEGAPGIG
IQGQRGIRGL SGPTGVPGPA GAKGDIGLPG PPGPIGEQGI GIPGPKGDRG HPGPPGPFGP
KGDGYPGLTG LPGLPGAPGE PGPDGVGLPG PKGNIGRQGP PGALGPPGEG IQGPKGEQGI
QGMPGPRGPP GEGLLGPKGR TGPKGVQGLT REDIIKLIKE ICGCGIKCKE IPMELVFVID
SSESVGPENF EIIKDFVTAL VDRVTVGRNA TRIGLVLYSL EVRLEFGLNR YTAQQDVKQA
IRKMLYMGEG TYTGTAIRKA TQEGFFGART GVRKVAIVLT DGQADKREAV KLDIAVREAH
AANIEMYAIG IVNTSDPTQV EFLRELNLIA SDPDREHMYL IDDFNTLPAL ESKLVNQFCE
DEHGALIYNR VGNGGSISGS LIHSVSSHTS QHLLHMNNKN GQAVSSMNIL RPPQCQLRLD
QGPCRVYIIK WYYDKQADSC AQFWYGGCNG NDNRFDREED CKKTCVLFSG GFPVSRIPHQ
ESGFSRKKGG GECMIQSLSN LFLKVLRKKS TLYFNRCLKI AHQTEWNRKD FLIRRKVEED
IYAFAKLRKI R
//