ID V8NV23_OPHHA Unreviewed; 1187 AA.
AC V8NV23;
DT 19-FEB-2014, integrated into UniProtKB/TrEMBL.
DT 19-FEB-2014, sequence version 1.
DT 27-MAR-2024, entry version 45.
DE RecName: Full=Eukaryotic translation initiation factor 5B {ECO:0000256|ARBA:ARBA00013824};
DE AltName: Full=Translation initiation factor IF-2 {ECO:0000256|ARBA:ARBA00032478};
DE Flags: Fragment;
GN Name=EIF5B {ECO:0000313|EMBL:ETE65518.1};
GN ORFNames=L345_08720 {ECO:0000313|EMBL:ETE65518.1};
OS Ophiophagus hannah (King cobra) (Naja hannah).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Lepidosauria; Squamata; Bifurcata; Unidentata; Episquamata; Toxicofera;
OC Serpentes; Colubroidea; Elapidae; Elapinae; Ophiophagus.
OX NCBI_TaxID=8665 {ECO:0000313|EMBL:ETE65518.1, ECO:0000313|Proteomes:UP000018936};
RN [1] {ECO:0000313|EMBL:ETE65518.1, ECO:0000313|Proteomes:UP000018936}
RP NUCLEOTIDE SEQUENCE.
RC TISSUE=Blood {ECO:0000313|EMBL:ETE65518.1};
RX PubMed=24297900; DOI=10.1073/pnas.1314702110;
RA Vonk F.J., Casewell N.R., Henkel C.V., Heimberg A.M., Jansen H.J.,
RA McCleary R.J., Kerkkamp H.M., Vos R.A., Guerreiro I., Calvete J.J.,
RA Wuster W., Woods A.E., Logan J.M., Harrison R.A., Castoe T.A.,
RA de Koning A.P., Pollock D.D., Yandell M., Calderon D., Renjifo C.,
RA Currier R.B., Salgado D., Pla D., Sanz L., Hyder A.S., Ribeiro J.M.,
RA Arntzen J.W., van den Thillart G.E., Boetzer M., Pirovano W., Dirks R.P.,
RA Spaink H.P., Duboule D., McGlinn E., Kini R.M., Richardson M.K.;
RT "The king cobra genome reveals dynamic gene evolution and adaptation in the
RT snake venom system.";
RL Proc. Natl. Acad. Sci. U.S.A. 110:20651-20656(2013).
CC -!- SIMILARITY: Belongs to the TRAFAC class translation factor GTPase
CC superfamily. Classic translation factor GTPase family. IF-2 subfamily.
CC {ECO:0000256|ARBA:ARBA00007733}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:ETE65518.1}.
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DR EMBL; AZIM01001864; ETE65518.1; -; Genomic_DNA.
DR AlphaFoldDB; V8NV23; -.
DR Proteomes; UP000018936; Unassembled WGS sequence.
DR GO; GO:0005525; F:GTP binding; IEA:InterPro.
DR GO; GO:0003924; F:GTPase activity; IEA:InterPro.
DR GO; GO:0003743; F:translation initiation factor activity; IEA:UniProtKB-KW.
DR CDD; cd03703; aeIF5B_II; 1.
DR CDD; cd16266; IF2_aeIF5B_IV; 1.
DR CDD; cd01887; IF2_eIF5B; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR Gene3D; 2.40.30.10; Translation factors; 2.
DR Gene3D; 3.40.50.10050; Translation initiation factor IF- 2, domain 3; 1.
DR InterPro; IPR029459; EFTU-type.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR005225; Small_GTP-bd_dom.
DR InterPro; IPR000795; T_Tr_GTP-bd_dom.
DR InterPro; IPR015760; TIF_IF2.
DR InterPro; IPR023115; TIF_IF2_dom3.
DR InterPro; IPR036925; TIF_IF2_dom3_sf.
DR InterPro; IPR009000; Transl_B-barrel_sf.
DR NCBIfam; TIGR00231; small_GTP; 1.
DR PANTHER; PTHR43381:SF4; EUKARYOTIC TRANSLATION INITIATION FACTOR 5B; 1.
DR PANTHER; PTHR43381; TRANSLATION INITIATION FACTOR IF-2-RELATED; 1.
DR Pfam; PF00009; GTP_EFTU; 1.
DR Pfam; PF14578; GTP_EFTU_D4; 1.
DR Pfam; PF11987; IF-2; 1.
DR PRINTS; PR00315; ELONGATNFCT.
DR SUPFAM; SSF52156; Initiation factor IF2/eIF5b, domain 3; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR SUPFAM; SSF50447; Translation proteins; 1.
DR PROSITE; PS51722; G_TR_2; 1.
PE 3: Inferred from homology;
KW Initiation factor {ECO:0000256|ARBA:ARBA00022540,
KW ECO:0000313|EMBL:ETE65518.1};
KW Protein biosynthesis {ECO:0000256|ARBA:ARBA00022917};
KW Reference proteome {ECO:0000313|Proteomes:UP000018936}.
FT DOMAIN 596..813
FT /note="Tr-type G"
FT /evidence="ECO:0000259|PROSITE:PS51722"
FT REGION 25..417
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 438..575
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 25..94
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 101..179
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 186..235
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 251..291
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 299..372
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 388..412
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 459..474
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 475..495
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 496..526
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 527..575
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT NON_TER 1
FT /evidence="ECO:0000313|EMBL:ETE65518.1"
SQ SEQUENCE 1187 AA; 135214 MW; C0C37A3072E0F717 CRC64;
MRLYPLRRVL KTEDDILKEL EELSLETQGG RVEKEPVVAK VENENEELGL SKQDKKKKGK
NKKASLEEED GSEETEEKEK KSKKSLKPKK ELLSESDDDD DDFDLKKRRG KVQKSGNKHE
FSEEDETGIV KKSKELAHPV SSGESEDELD EGSQAKKGQK KNQKVKLVAE TESGDDLNDS
SFKIKTVAQK KAEKKEREKK KREEEKAKLR KQKEKEDLEA NKEQAKMKKT DKRTASDQLS
TSATLEKGET PEAAEVNDNE GEKKKKDKDK KKKKGEKDEK EKEKKKGPSK ATVKAMQEAL
AKLKEEEERA KREEEERIRQ LEELEAKRKE EERLEQEKKE RKKQKEKERK ERLKKEGKLL
TKSQRESKAR AEVTLKLLQA QGVEVPSKDS IPKKRPIYED KKKKKQQQQE SREGDKCCLW
ITVNTETDIT ELASPVEEAA EIVVPEQEEI NLQAEPVSEE KEEEPEDGGL DDWEAMASDE
EREKERKTVH IEVKEQNDED EDEDEDEDED MEESEEYEEG ESEGSEEEKT SDEKESDPQA
SAKHSVEKKL NKEISSDSES DSDDDRTKEE RSYDKAKRRI EKRRIENNKN ANTEKLRAPV
ICVLGHVDTG KTKILDKLRH THVQDSEAGG ITQQIGATNV PLEAINEQAK MVKTFDRETV
KIPGMLIIDT PGHESFSNLR NRGSSLCDIA ILVVDIMHGL EPQTIESINL LKSKKCPFIV
ALNKIDRLYD WKKSPDTDVA VTLKKQKKNT KDEFEERAKA IIVEFAQQGL NAALYYENKD
PRTFVSLVPT SAHTGDGMGS LIALLVELTQ TMLNKRLAHC EELRAQVMEV KALPGMGTTI
DVILINGRLK EGDTIIVPGV EGPIVTQIRG LLLPPPMKEL RVKNQYEKHK EIIAAQGVKI
LGKDLEKTLA GLPLLVAYKE DEIPVLKDEL IHELKQTLNA IKLEEKGVYV QASTLGSLEA
LLEFLKTSEV PYAGINIGPV HKKDVMKASV MLEHDPQYAV ILAFDVRIER DAQEMADSLG
VRIFSAEIIY HLFDAFTKYR QDYKKQKQEE FKHIAVFPCK MKILPQFIFN SRDPIVMGVV
VDAGQVKQGT PICVPSKNFI DIGIITSIEI NHKQVDVAKK GQEVCVKIEP IPGEAPKMYG
RHFEATDILV SKISRQSIDA LKDWFRDEMQ KSDWQLIVEL KKVFEII
//
