ID V8NVH3_OPHHA Unreviewed; 1254 AA.
AC V8NVH3;
DT 19-FEB-2014, integrated into UniProtKB/TrEMBL.
DT 19-FEB-2014, sequence version 1.
DT 27-MAR-2024, entry version 42.
DE SubName: Full=Neurofascin {ECO:0000313|EMBL:ETE66249.1};
DE Flags: Fragment;
GN Name=NFASC {ECO:0000313|EMBL:ETE66249.1};
GN ORFNames=L345_07975 {ECO:0000313|EMBL:ETE66249.1};
OS Ophiophagus hannah (King cobra) (Naja hannah).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Lepidosauria; Squamata; Bifurcata; Unidentata; Episquamata; Toxicofera;
OC Serpentes; Colubroidea; Elapidae; Elapinae; Ophiophagus.
OX NCBI_TaxID=8665 {ECO:0000313|EMBL:ETE66249.1, ECO:0000313|Proteomes:UP000018936};
RN [1] {ECO:0000313|EMBL:ETE66249.1, ECO:0000313|Proteomes:UP000018936}
RP NUCLEOTIDE SEQUENCE.
RC TISSUE=Blood {ECO:0000313|EMBL:ETE66249.1};
RX PubMed=24297900; DOI=10.1073/pnas.1314702110;
RA Vonk F.J., Casewell N.R., Henkel C.V., Heimberg A.M., Jansen H.J.,
RA McCleary R.J., Kerkkamp H.M., Vos R.A., Guerreiro I., Calvete J.J.,
RA Wuster W., Woods A.E., Logan J.M., Harrison R.A., Castoe T.A.,
RA de Koning A.P., Pollock D.D., Yandell M., Calderon D., Renjifo C.,
RA Currier R.B., Salgado D., Pla D., Sanz L., Hyder A.S., Ribeiro J.M.,
RA Arntzen J.W., van den Thillart G.E., Boetzer M., Pirovano W., Dirks R.P.,
RA Spaink H.P., Duboule D., McGlinn E., Kini R.M., Richardson M.K.;
RT "The king cobra genome reveals dynamic gene evolution and adaptation in the
RT snake venom system.";
RL Proc. Natl. Acad. Sci. U.S.A. 110:20651-20656(2013).
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004479}; Single-
CC pass type I membrane protein {ECO:0000256|ARBA:ARBA00004479}.
CC -!- SIMILARITY: Belongs to the immunoglobulin superfamily.
CC L1/neurofascin/NgCAM family. {ECO:0000256|ARBA:ARBA00008588}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:ETE66249.1}.
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DR EMBL; AZIM01001615; ETE66249.1; -; Genomic_DNA.
DR AlphaFoldDB; V8NVH3; -.
DR Proteomes; UP000018936; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0007155; P:cell adhesion; IEA:UniProtKB-KW.
DR CDD; cd00063; FN3; 5.
DR CDD; cd05731; Ig3_L1-CAM_like; 1.
DR Gene3D; 2.60.40.10; Immunoglobulins; 9.
DR InterPro; IPR003961; FN3_dom.
DR InterPro; IPR036116; FN3_sf.
DR InterPro; IPR007110; Ig-like_dom.
DR InterPro; IPR036179; Ig-like_dom_sf.
DR InterPro; IPR013783; Ig-like_fold.
DR InterPro; IPR013098; Ig_I-set.
DR InterPro; IPR003599; Ig_sub.
DR InterPro; IPR003598; Ig_sub2.
DR InterPro; IPR026966; Neurofascin/L1/NrCAM_C.
DR PANTHER; PTHR44170:SF12; NEUROFASCIN; 1.
DR PANTHER; PTHR44170; PROTEIN SIDEKICK; 1.
DR Pfam; PF13882; Bravo_FIGEY; 1.
DR Pfam; PF00041; fn3; 4.
DR Pfam; PF07679; I-set; 4.
DR SMART; SM00060; FN3; 5.
DR SMART; SM00409; IG; 5.
DR SMART; SM00408; IGc2; 5.
DR SUPFAM; SSF49265; Fibronectin type III; 3.
DR SUPFAM; SSF48726; Immunoglobulin; 5.
DR PROSITE; PS50853; FN3; 4.
DR PROSITE; PS50835; IG_LIKE; 5.
PE 3: Inferred from homology;
KW Cell adhesion {ECO:0000256|ARBA:ARBA00022889};
KW Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Immunoglobulin domain {ECO:0000256|ARBA:ARBA00023319};
KW Membrane {ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000018936};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT TRANSMEM 1124..1145
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 38..119
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 156..244
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 254..327
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 333..420
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 424..511
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 518..613
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 618..713
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 718..820
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 824..920
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT REGION 987..1006
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1155..1254
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1159..1178
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1179..1202
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1225..1239
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1240..1254
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT NON_TER 1
FT /evidence="ECO:0000313|EMBL:ETE66249.1"
SQ SEQUENCE 1254 AA; 140172 MW; 0BC8BC84F7CB7F67 CRC64;
MVVVLASYLH NLIRAIEVPR DHAISLTRFI ISESPLWPKE NLDIQEVHEG ASLILACNPP
PGLPPPAIFW MSSSMEPIHQ DKRVSQGQNG DLYFSNVMQQ DALTDYSCNA RFAFTHTIQQ
KNPYTLKVLT KYPHNEASFR NHTDMYSARG IAERQPSFMY PLGTSSSQMV LRGEDLLLEC
IASGVPTPDI MWHKKGGDLP SGRIKLENFN KALHIANISE EDSGEYFCLA SNKVGISRHS
ILVKVKENLI LAPGEDGRLL CRANGNPKPS VQWLVNGELL ESSAPNPSRE VTGDTVMFRD
IQSGSSGVYQ CNASNEHGYL LANAFVSVLD VVPRILVPRN QLIKVIQNNR TLLDCPFFGS
PIPTLRWFKN GQGSTLHGGN YKAHENGTLE IIRARKEDQG TYTCVATNLL GKAQNQVRLE
IKDPTRIIEG PKDAVPKKGS TIHLVCQTRH DPTLRLTVTW LKDDIPVYFG NRMKKEEDGL
TIHGVSEKDQ GYYTCVASTE LDKDTARAHL TVLARPERPR DLELTDLAER SVRLTWIPGD
DNNSPITDYI VEFEEDKFQP GTWHNHSRYP GNVNSAILHL APYVNYQFRV IAVNDVGSSY
PSLPSERYHT NGARPEFNPS GVKGSGTAKN NMVISWTPLN ATQVYGPNLK YIVKWRRRDT
RESWNNRTVK GDVSQYTVAP TPIYTPYEIK VQALNDYGIA MEPDIIIGYS GEDYPKAAPT
DIRLKVVNST AISLQWSKVY PETIQGQLKE YRAYYWRESS LLKNLWVSKK KQSMGFIGDR
TRGIVSRLFP YSNYKLEMVV VNGRGDGPRS EILEFTTPEG VPSAPRYFRI RQPNLETVTL
EWEHPEHPNG ILIGYTLRYQ AFNGSKTGRT MVEVFSPNQT KFLLQRTDPI SRYRFNLRGR
TQIGEGEPAT GESPIPLNEV MQRSHIWFST MGRMEGEWMD DCFLHFPLLV LISPTIHQTT
DVPTVAATTI SETTVPTTIT EVVTTTTEVT PTTTTEAVTT TTTEATTTTE PAIITTLVAS
TIAGVGKLPP IWNVKISSNN NWANITWNHT FDADTEFVVE YSNSNKTVKS SPAKGFLELS
DLIPGEKYIV RVFLKGNESV FSSETFHTSP AYTKNQGDIA TQGWFIGLMC AIALLVLILL
IVCFIKRSRG GKYPVRANKD VPLDPDDQKV DNGSFDYSDE DNKPLQGSQT SLDGTIKQQE
SDDSLVDYGE GGEGQFNEDG SFIGQYTVKK DKEETEGNES SEATSPVNAI YSLA
//
