ID   V8NXE2_OPHHA            Unreviewed;       776 AA.
AC   V8NXE2;
DT   19-FEB-2014, integrated into UniProtKB/TrEMBL.
DT   19-FEB-2014, sequence version 1.
DT   22-FEB-2023, entry version 27.
DE   SubName: Full=Plakophilin-2 {ECO:0000313|EMBL:ETE66611.1};
GN   Name=PKP2 {ECO:0000313|EMBL:ETE66611.1};
GN   ORFNames=L345_07612 {ECO:0000313|EMBL:ETE66611.1};
OS   Ophiophagus hannah (King cobra) (Naja hannah).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Lepidosauria; Squamata; Bifurcata; Unidentata; Episquamata; Toxicofera;
OC   Serpentes; Colubroidea; Elapidae; Elapinae; Ophiophagus.
OX   NCBI_TaxID=8665 {ECO:0000313|EMBL:ETE66611.1, ECO:0000313|Proteomes:UP000018936};
RN   [1] {ECO:0000313|EMBL:ETE66611.1, ECO:0000313|Proteomes:UP000018936}
RP   NUCLEOTIDE SEQUENCE.
RC   TISSUE=Blood {ECO:0000313|EMBL:ETE66611.1};
RX   PubMed=24297900; DOI=10.1073/pnas.1314702110;
RA   Vonk F.J., Casewell N.R., Henkel C.V., Heimberg A.M., Jansen H.J.,
RA   McCleary R.J., Kerkkamp H.M., Vos R.A., Guerreiro I., Calvete J.J.,
RA   Wuster W., Woods A.E., Logan J.M., Harrison R.A., Castoe T.A.,
RA   de Koning A.P., Pollock D.D., Yandell M., Calderon D., Renjifo C.,
RA   Currier R.B., Salgado D., Pla D., Sanz L., Hyder A.S., Ribeiro J.M.,
RA   Arntzen J.W., van den Thillart G.E., Boetzer M., Pirovano W., Dirks R.P.,
RA   Spaink H.P., Duboule D., McGlinn E., Kini R.M., Richardson M.K.;
RT   "The king cobra genome reveals dynamic gene evolution and adaptation in the
RT   snake venom system.";
RL   Proc. Natl. Acad. Sci. U.S.A. 110:20651-20656(2013).
CC   -!- SIMILARITY: Belongs to the beta-catenin family.
CC       {ECO:0000256|ARBA:ARBA00005462}.
CC   -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC       whole genome shotgun (WGS) entry which is preliminary data.
CC       {ECO:0000313|EMBL:ETE66611.1}.
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DR   EMBL; AZIM01001519; ETE66611.1; -; Genomic_DNA.
DR   AlphaFoldDB; V8NXE2; -.
DR   Proteomes; UP000018936; Unassembled WGS sequence.
DR   GO; GO:0098609; P:cell-cell adhesion; IEA:InterPro.
DR   Gene3D; 1.25.10.10; Leucine-rich Repeat Variant; 1.
DR   InterPro; IPR011989; ARM-like.
DR   InterPro; IPR016024; ARM-type_fold.
DR   InterPro; IPR000225; Armadillo.
DR   InterPro; IPR028435; Plakophilin/d_Catenin.
DR   PANTHER; PTHR10372:SF25; PLAKOPHILIN-2; 1.
DR   PANTHER; PTHR10372; PLAKOPHILLIN-RELATED; 1.
DR   Pfam; PF00514; Arm; 2.
DR   SMART; SM00185; ARM; 6.
DR   SUPFAM; SSF48371; ARM repeat; 1.
DR   PROSITE; PS50176; ARM_REPEAT; 2.
PE   3: Inferred from homology;
KW   Cell adhesion {ECO:0000256|ARBA:ARBA00022889};
KW   Reference proteome {ECO:0000313|Proteomes:UP000018936}.
FT   REPEAT          374..409
FT                   /note="ARM"
FT                   /evidence="ECO:0000256|PROSITE-ProRule:PRU00259"
FT   REPEAT          416..459
FT                   /note="ARM"
FT                   /evidence="ECO:0000256|PROSITE-ProRule:PRU00259"
FT   REGION          253..285
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          577..605
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        587..605
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   776 AA;  86746 MW;  07FC3E9E2C14A70C CRC64;
     MAVHVSSSDS GYIRTVLGQQ GLEEQDSSTL ALPSRLSGGR AEAQKSLRIQ QQIQQTLARK
     SRSSLVNGGL HRASSVPEYV YKDAAETDFA SRSSFATSYY QSHQIGSQNS YENGWSPRSL
     PYNSYRAMEE RFHKQPLKRL EISPESSPEK PFLFHADMRY NRALTVRQNE NKRSCALPPR
     YARSEILGYT SRSASSRGPR QFYIGPTNET MVDCIPFNAG VPLYQRVGNS RSMSNLLEKE
     NYLTSGGAVG QARSSFHSQV GTQHRHSSWH QNTVKAQSTR ENSVPTSFAE AGGKRMTMTA
     AMAAAGANGT TEHERISASR SQVGNPEGEM NLERAVRILQ TENPLSSRVL AAIVFIQHES
     FQRAEARRKV YSLVGIPKLL ELLNVQNEEV QRAACGALRN LVYEDNDNKL EVSEQKGISI
     LLRLLRQTRD VETKKQITGL LWNLSSNDQL KNLLIREALE PLTQTVLIPY TGWPDRDYPK
     SSIIPDPDIF YNATGCIRNM SSAGPEGRKK MRECDGLIDS LVYYIQGTTA DRKPDDKATE
     NCVCILHNLS YQLEAELPSN YTEKLYVPKR DDPSTNNIGC FGTRSRKAKQ KQQDMPLPEE
     KSNPRSVEKL WHSTLIRIYL SLIAESTRNF TQEASLGALQ NLTAGSGPMP FGVAHIIVKK
     ANGLPNIRSM LHVSNVSIRK TAVSLLRNLS RNTLLQNEIA RLLLPELIAM LPDYVPTSDV
     DNEIAASVCY ALYNLIQNNS SNARLLLNND GVSKAGYKKM DFINNRTLRA YNLLKD
//