ID V8NY07_OPHHA Unreviewed; 635 AA.
AC V8NY07;
DT 19-FEB-2014, integrated into UniProtKB/TrEMBL.
DT 19-FEB-2014, sequence version 1.
DT 24-JAN-2024, entry version 26.
DE SubName: Full=Ectonucleoside triphosphate diphosphohydrolase 7 {ECO:0000313|EMBL:ETE66836.1};
DE Flags: Fragment;
GN Name=ENTPD7 {ECO:0000313|EMBL:ETE66836.1};
GN ORFNames=L345_07384 {ECO:0000313|EMBL:ETE66836.1};
OS Ophiophagus hannah (King cobra) (Naja hannah).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Lepidosauria; Squamata; Bifurcata; Unidentata; Episquamata; Toxicofera;
OC Serpentes; Colubroidea; Elapidae; Elapinae; Ophiophagus.
OX NCBI_TaxID=8665 {ECO:0000313|EMBL:ETE66836.1, ECO:0000313|Proteomes:UP000018936};
RN [1] {ECO:0000313|EMBL:ETE66836.1, ECO:0000313|Proteomes:UP000018936}
RP NUCLEOTIDE SEQUENCE.
RC TISSUE=Blood {ECO:0000313|EMBL:ETE66836.1};
RX PubMed=24297900; DOI=10.1073/pnas.1314702110;
RA Vonk F.J., Casewell N.R., Henkel C.V., Heimberg A.M., Jansen H.J.,
RA McCleary R.J., Kerkkamp H.M., Vos R.A., Guerreiro I., Calvete J.J.,
RA Wuster W., Woods A.E., Logan J.M., Harrison R.A., Castoe T.A.,
RA de Koning A.P., Pollock D.D., Yandell M., Calderon D., Renjifo C.,
RA Currier R.B., Salgado D., Pla D., Sanz L., Hyder A.S., Ribeiro J.M.,
RA Arntzen J.W., van den Thillart G.E., Boetzer M., Pirovano W., Dirks R.P.,
RA Spaink H.P., Duboule D., McGlinn E., Kini R.M., Richardson M.K.;
RT "The king cobra genome reveals dynamic gene evolution and adaptation in the
RT snake venom system.";
RL Proc. Natl. Acad. Sci. U.S.A. 110:20651-20656(2013).
CC -!- SIMILARITY: Belongs to the GDA1/CD39 NTPase family.
CC {ECO:0000256|ARBA:ARBA00009283, ECO:0000256|RuleBase:RU003833}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:ETE66836.1}.
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DR EMBL; AZIM01001465; ETE66836.1; -; Genomic_DNA.
DR AlphaFoldDB; V8NY07; -.
DR Proteomes; UP000018936; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0016787; F:hydrolase activity; IEA:UniProtKB-KW.
DR CDD; cd00012; NBD_sugar-kinase_HSP70_actin; 1.
DR Gene3D; 3.30.420.40; -; 1.
DR Gene3D; 3.30.420.150; Exopolyphosphatase. Domain 2; 1.
DR InterPro; IPR000407; GDA1_CD39_NTPase.
DR PANTHER; PTHR11782; ADENOSINE/GUANOSINE DIPHOSPHATASE; 1.
DR PANTHER; PTHR11782:SF37; ECTONUCLEOSIDE TRIPHOSPHATE DIPHOSPHOHYDROLASE 7; 1.
DR Pfam; PF01150; GDA1_CD39; 1.
DR PROSITE; PS01238; GDA1_CD39_NTPASE; 1.
PE 3: Inferred from homology;
KW ATP-binding {ECO:0000256|PIRSR:PIRSR600407-2};
KW Hydrolase {ECO:0000256|RuleBase:RU003833, ECO:0000313|EMBL:ETE66836.1};
KW Membrane {ECO:0000256|SAM:Phobius};
KW Nucleotide-binding {ECO:0000256|PIRSR:PIRSR600407-2};
KW Reference proteome {ECO:0000313|Proteomes:UP000018936};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT TRANSMEM 57..78
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 584..602
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT ACT_SITE 244
FT /note="Proton acceptor"
FT /evidence="ECO:0000256|PIRSR:PIRSR600407-1"
FT BINDING 293..297
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /evidence="ECO:0000256|PIRSR:PIRSR600407-2"
FT NON_TER 1
FT /evidence="ECO:0000313|EMBL:ETE66836.1"
SQ SEQUENCE 635 AA; 72433 MW; C42A480FAD01A9A1 CRC64;
MTAGLIKAAA LGPLRQLQPR PPIGRLFRAR SISFSCLCPA SWHFTLPSVS LCLRQRLALV
LLLFTVFLLL IVAIKNLWHW KTDSRDREFE RYLARYRALE ATDTKDPALS YGVVVDCGSS
GSRVFVYYWP PHNGNPHHLL DIRQMRDHSS EPVVKKIKPG ISTLAKTPEK ANEYMKPLLT
FAAAYVPKVK HKETPLYIMC TAGMRLLPDK QQEAILKDLV RDIPLEYDFL FSESQAEVIS
GKQEGVYAWI GINFVLGRFD HAEEEDALIS VTLSGQEEPM VRKRTVGILD MGGASLQIAY
EVPSSISFSS PQQEEAAKSL LADFNLGCDV QHTKHVYRVY VNTFLGFGGN FARQRYEELV
LNQTIAHNRL HSVQIGMNPE VPVLDPCLPM GLEEVVDKGR QAIHLRGQGD WRSCAEQLRP
LLAGDNSSGS SLSNSYQASI DFANSEFFGF SEFYYCTDDV LRLGGPYQSS TFTRAAQDYC
SLSWSVLLQR FHDKLYSRHA DLHRVKYQCF KSAWMHQVLH EGFHFPKDYS SLHTVQLLYD
REVQWTLGAI LYKTRFLPLR DIQRESFHQS HSSWFHLSFV YNHYLFFGCI LVVTLAIGLY
LLRLRRIHHQ PLQSAPLDLL WLEEVVPLPA QEEGS
//
