ID V8NZF4_OPHHA Unreviewed; 1209 AA.
AC V8NZF4;
DT 19-FEB-2014, integrated into UniProtKB/TrEMBL.
DT 19-FEB-2014, sequence version 1.
DT 24-JAN-2024, entry version 40.
DE SubName: Full=Tight junction protein ZO-2 {ECO:0000313|EMBL:ETE66962.1};
DE Flags: Fragment;
GN Name=TJP2 {ECO:0000313|EMBL:ETE66962.1};
GN ORFNames=L345_07251 {ECO:0000313|EMBL:ETE66962.1};
OS Ophiophagus hannah (King cobra) (Naja hannah).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Lepidosauria; Squamata; Bifurcata; Unidentata; Episquamata; Toxicofera;
OC Serpentes; Colubroidea; Elapidae; Elapinae; Ophiophagus.
OX NCBI_TaxID=8665 {ECO:0000313|EMBL:ETE66962.1, ECO:0000313|Proteomes:UP000018936};
RN [1] {ECO:0000313|EMBL:ETE66962.1, ECO:0000313|Proteomes:UP000018936}
RP NUCLEOTIDE SEQUENCE.
RC TISSUE=Blood {ECO:0000313|EMBL:ETE66962.1};
RX PubMed=24297900; DOI=10.1073/pnas.1314702110;
RA Vonk F.J., Casewell N.R., Henkel C.V., Heimberg A.M., Jansen H.J.,
RA McCleary R.J., Kerkkamp H.M., Vos R.A., Guerreiro I., Calvete J.J.,
RA Wuster W., Woods A.E., Logan J.M., Harrison R.A., Castoe T.A.,
RA de Koning A.P., Pollock D.D., Yandell M., Calderon D., Renjifo C.,
RA Currier R.B., Salgado D., Pla D., Sanz L., Hyder A.S., Ribeiro J.M.,
RA Arntzen J.W., van den Thillart G.E., Boetzer M., Pirovano W., Dirks R.P.,
RA Spaink H.P., Duboule D., McGlinn E., Kini R.M., Richardson M.K.;
RT "The king cobra genome reveals dynamic gene evolution and adaptation in the
RT snake venom system.";
RL Proc. Natl. Acad. Sci. U.S.A. 110:20651-20656(2013).
CC -!- SUBCELLULAR LOCATION: Cell junction, tight junction
CC {ECO:0000256|ARBA:ARBA00004435}. Cell membrane
CC {ECO:0000256|ARBA:ARBA00004413}; Peripheral membrane protein
CC {ECO:0000256|ARBA:ARBA00004413}; Cytoplasmic side
CC {ECO:0000256|ARBA:ARBA00004413}. Membrane
CC {ECO:0000256|ARBA:ARBA00004287}; Peripheral membrane protein
CC {ECO:0000256|ARBA:ARBA00004287}; Cytoplasmic side
CC {ECO:0000256|ARBA:ARBA00004287}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:ETE66962.1}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; AZIM01001418; ETE66962.1; -; Genomic_DNA.
DR AlphaFoldDB; V8NZF4; -.
DR Proteomes; UP000018936; Unassembled WGS sequence.
DR GO; GO:0005923; C:bicellular tight junction; IEA:UniProtKB-SubCell.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR CDD; cd00992; PDZ_signaling; 3.
DR CDD; cd12027; SH3_ZO-2; 1.
DR Gene3D; 2.30.42.10; -; 3.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR Gene3D; 2.30.30.40; SH3 Domains; 1.
DR InterPro; IPR008145; GK/Ca_channel_bsu.
DR InterPro; IPR008144; Guanylate_kin-like_dom.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR001478; PDZ.
DR InterPro; IPR036034; PDZ_sf.
DR InterPro; IPR036028; SH3-like_dom_sf.
DR InterPro; IPR001452; SH3_domain.
DR InterPro; IPR005417; ZO.
DR InterPro; IPR005419; ZO-2.
DR InterPro; IPR035598; ZO-2_SH3.
DR PANTHER; PTHR13865; TIGHT JUNCTION PROTEIN; 1.
DR PANTHER; PTHR13865:SF26; TIGHT JUNCTION PROTEIN ZO-2; 1.
DR Pfam; PF00625; Guanylate_kin; 1.
DR Pfam; PF00595; PDZ; 3.
DR Pfam; PF07653; SH3_2; 1.
DR PRINTS; PR01597; ZONOCCLUDNS.
DR PRINTS; PR01599; ZONOCCLUDNS2.
DR SMART; SM00072; GuKc; 1.
DR SMART; SM00228; PDZ; 3.
DR SMART; SM00326; SH3; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR SUPFAM; SSF50156; PDZ domain-like; 3.
DR SUPFAM; SSF50044; SH3-domain; 1.
DR PROSITE; PS50052; GUANYLATE_KINASE_2; 1.
DR PROSITE; PS50106; PDZ; 3.
DR PROSITE; PS50002; SH3; 1.
PE 4: Predicted;
KW Cell junction {ECO:0000256|ARBA:ARBA00022949};
KW Cell membrane {ECO:0000256|ARBA:ARBA00022475};
KW Membrane {ECO:0000256|ARBA:ARBA00022475};
KW Reference proteome {ECO:0000313|Proteomes:UP000018936};
KW SH3 domain {ECO:0000256|ARBA:ARBA00022443, ECO:0000256|PROSITE-
KW ProRule:PRU00192}; Tight junction {ECO:0000256|ARBA:ARBA00022427}.
FT DOMAIN 128..215
FT /note="PDZ"
FT /evidence="ECO:0000259|PROSITE:PS50106"
FT DOMAIN 359..433
FT /note="PDZ"
FT /evidence="ECO:0000259|PROSITE:PS50106"
FT DOMAIN 558..624
FT /note="PDZ"
FT /evidence="ECO:0000259|PROSITE:PS50106"
FT DOMAIN 653..718
FT /note="SH3"
FT /evidence="ECO:0000259|PROSITE:PS50002"
FT DOMAIN 823..925
FT /note="Guanylate kinase-like"
FT /evidence="ECO:0000259|PROSITE:PS50052"
FT REGION 230..363
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 445..508
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 940..1071
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1130..1209
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 232..250
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 259..312
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 322..344
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 453..494
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 976..1000
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1016..1030
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1147..1161
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT NON_TER 1
FT /evidence="ECO:0000313|EMBL:ETE66962.1"
SQ SEQUENCE 1209 AA; 137226 MW; CA5EEAD98305D109 CRC64;
MLEMAHRYHT KDFWGLVIST YPEVGMKTRS RDETWLIKFR MKCKKYVAIL EAAVGITPLN
KREMLPVVRH VNLWQQPGDQ TSIYPSPCEW DCSCNLNPRH FTGSALRRLK PDLPQGPVME
ELIWEQYTVT LQKDSKRGFG IAVSGGRDNP HFENGETSIV VSDVLAGGPA DGLLQENDRV
IMVNGTPMEN VAHAFAVQQL RKIQRSPSLD YDYRAFEAVD DRAEFDGRST RSVYSERSWQ
SGNAGRSQSW GDNLDRGYRM TPNKGRTHSR ERSFSRDRSR GRSMDRERSL DREYQRPRSR
GRSVDRYDTY DYGYDGGRSL PRDYDWQSRP DPQRGREKKS GSRDRLSTQS PTSDPYDCRT
QEEPVKYGLR LGSQIFIKEM TSTGLATKDG NLHEGDIILK INGTVTENMS LSDARKLIEK
SRGKLQLVVM RDKRQTLINI PTMQDSESEM EDISEIESNR SCSPQDERRL HHSDVEFHSS
NEKLKEKLSG KEDPTNRLSK MGAMPTPFRS TVDSTAGLIP ETNSQVKYQD DPPVVHSKPA
TRIFLQPNPE DQAIYGPDTK MVQFRKGDSV GLRLAGGNDV GIFVAGIQEG TSAEQEGLQE
GDQILKVNSQ DFRGIIREDA VLYLLEIPKG DIVTILAQSK YDVYRDIMAC GRGDSFFIRT
HFECEKETPH SLAFTRGDVF RVVDTLYDGK LGHWLAVRID SELEKGLIPN KSRAEQLASV
QNAQRDGSSD RADFWRMRGQ RSGMKKNLKK SREDLTAIAS VGTKFPAYER VMLREAGFRR
PVVIFGPIAD IAMEKLYNEL PELYQPAKTE PKDAGSEKSA GVVRLNTVRQ IIEQDKHALL
DVTPKAVDLL NYTQWFPIVV FFNPDSKQCV KVMRQRLIPT SNKSARKLYD QANKLKKTCF
HLFTASIDLN SANDGWYGSL KDTIQQQQNE AVCDSRLISD MEDTDGEGGA YTDNELDEPY
YEPRVSSIGR SSEPVQQEEN LRKFSPEPKG QMRKAGSREV LRDPSPPPAF KPEPPKAKLQ
NKEDPYDMPK NYEPRTNSPN AASIENLGGP AKIAPPPIAM KPNFGRPVLK TSQPIIQPSE
VEEKVGEVVE ENTPKSVLGK VKIFEKMDHK ARLQRMQELQ EAQNARVEIA QKHPDIYAVP
MKTQKPEHNR PQISSSRPPE PQKPAVRSYV DNPGVYGSDA EEEDYRRQLS DQSKRGYYGQ
PSRYRDTEL
//
