ID V8P408_OPHHA Unreviewed; 870 AA.
AC V8P408;
DT 19-FEB-2014, integrated into UniProtKB/TrEMBL.
DT 19-FEB-2014, sequence version 1.
DT 27-MAR-2024, entry version 26.
DE SubName: Full=Transmembrane protein 63C {ECO:0000313|EMBL:ETE68753.1};
DE Flags: Fragment;
GN Name=TMEM63C {ECO:0000313|EMBL:ETE68753.1};
GN ORFNames=L345_05442 {ECO:0000313|EMBL:ETE68753.1};
OS Ophiophagus hannah (King cobra) (Naja hannah).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Lepidosauria; Squamata; Bifurcata; Unidentata; Episquamata; Toxicofera;
OC Serpentes; Colubroidea; Elapidae; Elapinae; Ophiophagus.
OX NCBI_TaxID=8665 {ECO:0000313|EMBL:ETE68753.1, ECO:0000313|Proteomes:UP000018936};
RN [1] {ECO:0000313|EMBL:ETE68753.1, ECO:0000313|Proteomes:UP000018936}
RP NUCLEOTIDE SEQUENCE.
RC TISSUE=Blood {ECO:0000313|EMBL:ETE68753.1};
RX PubMed=24297900; DOI=10.1073/pnas.1314702110;
RA Vonk F.J., Casewell N.R., Henkel C.V., Heimberg A.M., Jansen H.J.,
RA McCleary R.J., Kerkkamp H.M., Vos R.A., Guerreiro I., Calvete J.J.,
RA Wuster W., Woods A.E., Logan J.M., Harrison R.A., Castoe T.A.,
RA de Koning A.P., Pollock D.D., Yandell M., Calderon D., Renjifo C.,
RA Currier R.B., Salgado D., Pla D., Sanz L., Hyder A.S., Ribeiro J.M.,
RA Arntzen J.W., van den Thillart G.E., Boetzer M., Pirovano W., Dirks R.P.,
RA Spaink H.P., Duboule D., McGlinn E., Kini R.M., Richardson M.K.;
RT "The king cobra genome reveals dynamic gene evolution and adaptation in the
RT snake venom system.";
RL Proc. Natl. Acad. Sci. U.S.A. 110:20651-20656(2013).
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the CSC1 (TC 1.A.17) family.
CC {ECO:0000256|ARBA:ARBA00007779}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:ETE68753.1}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; AZIM01000947; ETE68753.1; -; Genomic_DNA.
DR AlphaFoldDB; V8P408; -.
DR Proteomes; UP000018936; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005227; F:calcium-activated cation channel activity; IEA:InterPro.
DR InterPro; IPR045122; Csc1-like.
DR InterPro; IPR003864; CSC1/OSCA1-like_7TM.
DR InterPro; IPR027815; CSC1/OSCA1-like_cyt.
DR InterPro; IPR032880; Csc1/OSCA1-like_N.
DR PANTHER; PTHR13018:SF21; CALCIUM PERMEABLE STRESS-GATED CATION CHANNEL 1; 1.
DR PANTHER; PTHR13018; PROBABLE MEMBRANE PROTEIN DUF221-RELATED; 1.
DR Pfam; PF14703; PHM7_cyt; 1.
DR Pfam; PF02714; RSN1_7TM; 1.
DR Pfam; PF13967; RSN1_TM; 1.
PE 3: Inferred from homology;
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000018936};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}; Transport {ECO:0000256|ARBA:ARBA00022448}.
FT TRANSMEM 118..137
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 219..241
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 261..278
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 468..488
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 508..531
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 552..575
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 658..688
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 709..731
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 743..764
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 118..277
FT /note="CSC1/OSCA1-like N-terminal transmembrane"
FT /evidence="ECO:0000259|Pfam:PF13967"
FT DOMAIN 278..456
FT /note="CSC1/OSCA1-like cytosolic"
FT /evidence="ECO:0000259|Pfam:PF14703"
FT DOMAIN 469..738
FT /note="CSC1/OSCA1-like 7TM region"
FT /evidence="ECO:0000259|Pfam:PF02714"
FT NON_TER 1
FT /evidence="ECO:0000313|EMBL:ETE68753.1"
SQ SEQUENCE 870 AA; 99287 MW; 78FB5DA258D22B4E CRC64;
MLGPWVGPVK FLYPSGIQHK SMTQRDSLPA NSEVASGLWD EMPLKRAQSF LGMLIPKPEV
LIMDNMIMTT SSPEDTSSIS LNVLMHLDTL TNSTEEQCFS ARSHSTVLQG LPFGGVPTVL
ALNFLLWMVL LFIFSCLRKA AWDYGRLALL MDNDSLTSLF YGEQSEKEKS PSESSPLDAD
NKDVGFCSWL LSIYQMKDEE IQSKCGIDAT TYLSFQRHLL VLLLIVCVLS VAVILPVNFS
GKNPANFGRT TIANVPKDDR LLWLHSIFAL LYFIITLART LMVTKIPKEI TDTSLVIKHF
HEAYPSCTVT GVQFCSDVRR LMKLDSERRK AMKGRLYFTT KAQKEGKIMI KIHPCSRIFC
CRICGFEEVD AEQYYGELEE KLTDEFNAER SRIALKRLDM AFVTFQDERM TATILKDYSR
IRCRKHPQQS SVTTVVKSHC WGVSYAPAPN DIIWENLSIG GALWWVKFIL LNICLFILLF
FLTTPAIIVN TMDMFNVTRP VETLKNPIVT QFFPTLLLWA FSVFLPFIVY YSAFFESHWT
RSSENQITMH KCYFFLVFMV IILPSLGLTS LDLFFRWLFD THFVDQAEIK FQCVFLPDNG
AFFVNYVVTS SLIGTAMELL RIPGLIVYAT RLCFAKSEPE RLHIKRNQAY EFQFGLEYAW
TCCIFAVVMT YSITCPIIVP FGLLYMLLKH MVDRYNIYYV YIPTRLNHRI HLAAVNQVVT
APILCMFWLL FFSILRLGSV RPITIFTCVV LLSCIPFSFF GLCLKKFHPR KPSSYQMSEQ
SDGAFNDTET SSISSTPNSN MFVATVLQEP ELSLTPAASP AHQSYGTMGS HLDQAENIEE
GGLPSFEAEL ENTEGKYRTR PLLDTQTHYH
//
