ID   V8P7K7_OPHHA            Unreviewed;       386 AA.
AC   V8P7K7;
DT   19-FEB-2014, integrated into UniProtKB/TrEMBL.
DT   19-FEB-2014, sequence version 1.
DT   27-MAR-2024, entry version 15.
DE   RecName: Full=Kelch domain-containing protein 8B {ECO:0000256|ARBA:ARBA00041086};
DE   Flags: Fragment;
GN   Name=KLHDC8B {ECO:0000313|EMBL:ETE69877.1};
GN   ORFNames=L345_04322 {ECO:0000313|EMBL:ETE69877.1};
OS   Ophiophagus hannah (King cobra) (Naja hannah).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Lepidosauria; Squamata; Bifurcata; Unidentata; Episquamata; Toxicofera;
OC   Serpentes; Colubroidea; Elapidae; Elapinae; Ophiophagus.
OX   NCBI_TaxID=8665 {ECO:0000313|EMBL:ETE69877.1, ECO:0000313|Proteomes:UP000018936};
RN   [1] {ECO:0000313|EMBL:ETE69877.1, ECO:0000313|Proteomes:UP000018936}
RP   NUCLEOTIDE SEQUENCE.
RC   TISSUE=Blood {ECO:0000313|EMBL:ETE69877.1};
RX   PubMed=24297900; DOI=10.1073/pnas.1314702110;
RA   Vonk F.J., Casewell N.R., Henkel C.V., Heimberg A.M., Jansen H.J.,
RA   McCleary R.J., Kerkkamp H.M., Vos R.A., Guerreiro I., Calvete J.J.,
RA   Wuster W., Woods A.E., Logan J.M., Harrison R.A., Castoe T.A.,
RA   de Koning A.P., Pollock D.D., Yandell M., Calderon D., Renjifo C.,
RA   Currier R.B., Salgado D., Pla D., Sanz L., Hyder A.S., Ribeiro J.M.,
RA   Arntzen J.W., van den Thillart G.E., Boetzer M., Pirovano W., Dirks R.P.,
RA   Spaink H.P., Duboule D., McGlinn E., Kini R.M., Richardson M.K.;
RT   "The king cobra genome reveals dynamic gene evolution and adaptation in the
RT   snake venom system.";
RL   Proc. Natl. Acad. Sci. U.S.A. 110:20651-20656(2013).
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|ARBA:ARBA00004496}.
CC       Midbody {ECO:0000256|ARBA:ARBA00004214}.
CC   -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC       whole genome shotgun (WGS) entry which is preliminary data.
CC       {ECO:0000313|EMBL:ETE69877.1}.
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DR   EMBL; AZIM01000670; ETE69877.1; -; Genomic_DNA.
DR   AlphaFoldDB; V8P7K7; -.
DR   Proteomes; UP000018936; Unassembled WGS sequence.
DR   Gene3D; 2.120.10.80; Kelch-type beta propeller; 2.
DR   InterPro; IPR015915; Kelch-typ_b-propeller.
DR   InterPro; IPR006652; Kelch_1.
DR   PANTHER; PTHR46260:SF2; KELCH DOMAIN-CONTAINING PROTEIN 8B; 1.
DR   PANTHER; PTHR46260; RING-TYPE DOMAIN-CONTAINING PROTEIN; 1.
DR   Pfam; PF01344; Kelch_1; 3.
DR   SMART; SM00612; Kelch; 5.
DR   SUPFAM; SSF117281; Kelch motif; 2.
PE   4: Predicted;
KW   Kelch repeat {ECO:0000256|ARBA:ARBA00022441};
KW   Reference proteome {ECO:0000313|Proteomes:UP000018936};
KW   Repeat {ECO:0000256|ARBA:ARBA00022737}.
FT   NON_TER         1
FT                   /evidence="ECO:0000313|EMBL:ETE69877.1"
FT   NON_TER         386
FT                   /evidence="ECO:0000313|EMBL:ETE69877.1"
SQ   SEQUENCE   386 AA;  41623 MW;  F99A768E0BE24A4D CRC64;
     ILEKNGSFSC GDPNAWSSRQ SLPVSLGHPG LSRQSELPPN VLGHCGCGVA KVEEISPSIC
     FRPWGKMEAA NTKSFFWETF PPMPTCRVYC SPTYQDGHLF VVGGCSQQGQ PLDTLEMLDV
     VSHKWMALPS MATPRAGAAA VMLGKEVLVI GGVDSTQRPL ASVEVYHTDE GRWEKKADLA
     QPSMGISALE KDGVVYALGG MGADTSPQAL LRMYEPAKDH WQPLPSMPTP CYGASTFLHG
     NKIYVMGGRQ GKLPVTAFEA FDLEVRSWTR YPSVPSRRAF ASCAMAEGCF FSLGGLQQPG
     PHNFYSRPHF VNTVEMFDLE EGNQSSALGS AEGFNPAKKK WEPLPSMPTG RCSCATLEAP
     NLLFVIGGVA QGPSSAVEAL SLQEEV
//