ID V8P7U1_OPHHA Unreviewed; 780 AA.
AC V8P7U1;
DT 19-FEB-2014, integrated into UniProtKB/TrEMBL.
DT 19-FEB-2014, sequence version 1.
DT 27-MAR-2024, entry version 49.
DE SubName: Full=Nuclear receptor subfamily 2 group C member 1 {ECO:0000313|EMBL:ETE69952.1};
DE Flags: Fragment;
GN Name=NR2C1 {ECO:0000313|EMBL:ETE69952.1};
GN ORFNames=L345_04241 {ECO:0000313|EMBL:ETE69952.1};
OS Ophiophagus hannah (King cobra) (Naja hannah).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Lepidosauria; Squamata; Bifurcata; Unidentata; Episquamata; Toxicofera;
OC Serpentes; Colubroidea; Elapidae; Elapinae; Ophiophagus.
OX NCBI_TaxID=8665 {ECO:0000313|EMBL:ETE69952.1, ECO:0000313|Proteomes:UP000018936};
RN [1] {ECO:0000313|EMBL:ETE69952.1, ECO:0000313|Proteomes:UP000018936}
RP NUCLEOTIDE SEQUENCE.
RC TISSUE=Blood {ECO:0000313|EMBL:ETE69952.1};
RX PubMed=24297900; DOI=10.1073/pnas.1314702110;
RA Vonk F.J., Casewell N.R., Henkel C.V., Heimberg A.M., Jansen H.J.,
RA McCleary R.J., Kerkkamp H.M., Vos R.A., Guerreiro I., Calvete J.J.,
RA Wuster W., Woods A.E., Logan J.M., Harrison R.A., Castoe T.A.,
RA de Koning A.P., Pollock D.D., Yandell M., Calderon D., Renjifo C.,
RA Currier R.B., Salgado D., Pla D., Sanz L., Hyder A.S., Ribeiro J.M.,
RA Arntzen J.W., van den Thillart G.E., Boetzer M., Pirovano W., Dirks R.P.,
RA Spaink H.P., Duboule D., McGlinn E., Kini R.M., Richardson M.K.;
RT "The king cobra genome reveals dynamic gene evolution and adaptation in the
RT snake venom system.";
RL Proc. Natl. Acad. Sci. U.S.A. 110:20651-20656(2013).
CC -!- SUBCELLULAR LOCATION: Nucleus, PML body
CC {ECO:0000256|ARBA:ARBA00004322}.
CC -!- SIMILARITY: Belongs to the nuclear hormone receptor family. NR2
CC subfamily. {ECO:0000256|ARBA:ARBA00006421}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:ETE69952.1}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; AZIM01000654; ETE69952.1; -; Genomic_DNA.
DR AlphaFoldDB; V8P7U1; -.
DR Proteomes; UP000018936; Unassembled WGS sequence.
DR GO; GO:0016605; C:PML body; IEA:UniProtKB-SubCell.
DR GO; GO:0003700; F:DNA-binding transcription factor activity; IEA:InterPro.
DR GO; GO:0043565; F:sequence-specific DNA binding; IEA:InterPro.
DR GO; GO:0008270; F:zinc ion binding; IEA:InterPro.
DR CDD; cd06967; NR_DBD_TR2_like; 1.
DR CDD; cd06952; NR_LBD_TR2_like; 1.
DR Gene3D; 3.30.50.10; Erythroid Transcription Factor GATA-1, subunit A; 1.
DR Gene3D; 1.10.565.10; Retinoid X Receptor; 1.
DR Gene3D; 3.30.40.10; Zinc/RING finger domain, C3HC4 (zinc finger); 1.
DR InterPro; IPR035500; NHR-like_dom_sf.
DR InterPro; IPR048245; NR2C1/2-like_DBD.
DR InterPro; IPR048246; NR2C1/2-like_LBD.
DR InterPro; IPR000536; Nucl_hrmn_rcpt_lig-bd.
DR InterPro; IPR001723; Nuclear_hrmn_rcpt.
DR InterPro; IPR000306; Znf_FYVE.
DR InterPro; IPR011011; Znf_FYVE_PHD.
DR InterPro; IPR001628; Znf_hrmn_rcpt.
DR InterPro; IPR013088; Znf_NHR/GATA.
DR InterPro; IPR013083; Znf_RING/FYVE/PHD.
DR PANTHER; PTHR24083; NUCLEAR HORMONE RECEPTOR; 1.
DR PANTHER; PTHR24083:SF49; NUCLEAR RECEPTOR SUBFAMILY 2 GROUP C MEMBER 1; 1.
DR Pfam; PF01363; FYVE; 1.
DR Pfam; PF00104; Hormone_recep; 1.
DR Pfam; PF00105; zf-C4; 1.
DR PRINTS; PR00398; STRDHORMONER.
DR PRINTS; PR00047; STROIDFINGER.
DR SMART; SM00064; FYVE; 1.
DR SMART; SM00430; HOLI; 1.
DR SMART; SM00399; ZnF_C4; 1.
DR SUPFAM; SSF57903; FYVE/PHD zinc finger; 1.
DR SUPFAM; SSF57716; Glucocorticoid receptor-like (DNA-binding domain); 1.
DR SUPFAM; SSF48508; Nuclear receptor ligand-binding domain; 1.
DR SUPFAM; SSF50729; PH domain-like; 1.
DR PROSITE; PS51843; NR_LBD; 1.
DR PROSITE; PS00031; NUCLEAR_REC_DBD_1; 1.
DR PROSITE; PS51030; NUCLEAR_REC_DBD_2; 1.
PE 3: Inferred from homology;
KW DNA-binding {ECO:0000256|ARBA:ARBA00023125, ECO:0000256|RuleBase:RU004334};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723,
KW ECO:0000256|RuleBase:RU004334};
KW Nucleus {ECO:0000256|ARBA:ARBA00023242, ECO:0000256|RuleBase:RU004334};
KW Receptor {ECO:0000256|ARBA:ARBA00023170, ECO:0000256|RuleBase:RU004334};
KW Reference proteome {ECO:0000313|Proteomes:UP000018936};
KW Repressor {ECO:0000256|ARBA:ARBA00022491};
KW Transcription {ECO:0000256|ARBA:ARBA00023163,
KW ECO:0000256|RuleBase:RU004334};
KW Transcription regulation {ECO:0000256|ARBA:ARBA00023015,
KW ECO:0000256|RuleBase:RU004334};
KW Zinc {ECO:0000256|ARBA:ARBA00022833, ECO:0000256|RuleBase:RU004334};
KW Zinc-finger {ECO:0000256|ARBA:ARBA00022771, ECO:0000256|RuleBase:RU004334}.
FT DOMAIN 302..377
FT /note="Nuclear receptor"
FT /evidence="ECO:0000259|PROSITE:PS51030"
FT DOMAIN 512..767
FT /note="NR LBD"
FT /evidence="ECO:0000259|PROSITE:PS51843"
FT NON_TER 780
FT /evidence="ECO:0000313|EMBL:ETE69952.1"
SQ SEQUENCE 780 AA; 86851 MW; 2A0357F204ED11B1 CRC64;
MKQGDNFQKL MQIQYSLTGH HEIVQPGRFN DTLLYTTPLQ SGMYKLNNML SLAGMKADQE
KEEERPVGSK APIWIPDTRA TMCMICTSEF TLTWRRHHCR ACGKVVSANT EDSSISGYLY
RSKGTKKPWK HLWFVIKNKV LYTYAASEDV AALESQPLLG FTVAEVKDEH LESKITHSQG
SVTQTLMDGT AQRIQIVPAD AGLSLPQRIQ IVTDQQTGQK IQIVTALDQT ATSKQFILTN
HDGSAPSKVI LARQDATPGK VFLTTPDAAG GQLFFTTPDI SAQHIQILTD NSSTEQTLNK
VFDLCVVCGD KASGRHYGAV TCEGCKGFFK RSIRKNLVYS CRGTRDCVIN KHHRNRCQYC
RLQRCIAFGM KQDSVQCERK PVEASREKSS NCAASTEKIY IRKDLRSPLT ATPTFVTDSE
TARSTGMLES GMFVNIHQSG LKNEPAVLMT ADKVETCQGD LSTLANVVTS LANLNKSKDI
SQNSDDLSMI ENLSNGDTSL SELQQDEHAS ADVSRAFDTL AKALNPGEST PCPSSAESME
ASAHLAGEEA SMNILTMPSP MPEYLNVHYI CESASRLLFL SMHWARSIPS FQALGQDNSI
SLVKACWNEL FTLGLAQCSQ VMNVATILTA FVNHLHNSLQ QDKLSEDRGK LVMEHIFKLQ
EFCNSMVKLC LDGYEYAYLK AIVLFSPDHP GLENVEQIEK FQEKAYMEFQ DYVMKVYPDD
TYRLSRLLLR LPALRLMSAA ITEELFFAGL IGNVQIDSII PYILRMETAD YNSQIIGHTI
//
