ID V8P8N4_OPHHA Unreviewed; 371 AA.
AC V8P8N4;
DT 19-FEB-2014, integrated into UniProtKB/TrEMBL.
DT 19-FEB-2014, sequence version 1.
DT 27-MAR-2024, entry version 36.
DE RecName: Full=tRNA (guanine(10)-N2)-methyltransferase homolog {ECO:0000256|ARBA:ARBA00013960};
DE AltName: Full=tRNA guanosine-2'-O-methyltransferase TRM11 homolog {ECO:0000256|ARBA:ARBA00032604};
DE Flags: Fragment;
GN Name=HEMK1 {ECO:0000313|EMBL:ETE70373.1};
GN ORFNames=L345_03813 {ECO:0000313|EMBL:ETE70373.1};
OS Ophiophagus hannah (King cobra) (Naja hannah).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Lepidosauria; Squamata; Bifurcata; Unidentata; Episquamata; Toxicofera;
OC Serpentes; Colubroidea; Elapidae; Elapinae; Ophiophagus.
OX NCBI_TaxID=8665 {ECO:0000313|EMBL:ETE70373.1, ECO:0000313|Proteomes:UP000018936};
RN [1] {ECO:0000313|EMBL:ETE70373.1, ECO:0000313|Proteomes:UP000018936}
RP NUCLEOTIDE SEQUENCE.
RC TISSUE=Blood {ECO:0000313|EMBL:ETE70373.1};
RX PubMed=24297900; DOI=10.1073/pnas.1314702110;
RA Vonk F.J., Casewell N.R., Henkel C.V., Heimberg A.M., Jansen H.J.,
RA McCleary R.J., Kerkkamp H.M., Vos R.A., Guerreiro I., Calvete J.J.,
RA Wuster W., Woods A.E., Logan J.M., Harrison R.A., Castoe T.A.,
RA de Koning A.P., Pollock D.D., Yandell M., Calderon D., Renjifo C.,
RA Currier R.B., Salgado D., Pla D., Sanz L., Hyder A.S., Ribeiro J.M.,
RA Arntzen J.W., van den Thillart G.E., Boetzer M., Pirovano W., Dirks R.P.,
RA Spaink H.P., Duboule D., McGlinn E., Kini R.M., Richardson M.K.;
RT "The king cobra genome reveals dynamic gene evolution and adaptation in the
RT snake venom system.";
RL Proc. Natl. Acad. Sci. U.S.A. 110:20651-20656(2013).
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:ETE70373.1}.
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DR EMBL; AZIM01000562; ETE70373.1; -; Genomic_DNA.
DR AlphaFoldDB; V8P8N4; -.
DR Proteomes; UP000018936; Unassembled WGS sequence.
DR GO; GO:0008168; F:methyltransferase activity; IEA:UniProtKB-KW.
DR GO; GO:0000049; F:tRNA binding; IEA:UniProtKB-KW.
DR GO; GO:0032259; P:methylation; IEA:UniProtKB-KW.
DR GO; GO:0034470; P:ncRNA processing; IEA:UniProt.
DR GO; GO:0009451; P:RNA modification; IEA:UniProt.
DR Gene3D; 1.10.8.10; DNA helicase RuvA subunit, C-terminal domain; 1.
DR Gene3D; 3.40.50.150; Vaccinia Virus protein VP39; 1.
DR InterPro; IPR002052; DNA_methylase_N6_adenine_CS.
DR InterPro; IPR040758; PrmC_N.
DR InterPro; IPR000241; RlmKL-like_Mtase.
DR InterPro; IPR029063; SAM-dependent_MTases_sf.
DR PANTHER; PTHR18895; HEMK METHYLTRANSFERASE; 1.
DR PANTHER; PTHR18895:SF74; MTRF1L RELEASE FACTOR GLUTAMINE METHYLTRANSFERASE; 1.
DR Pfam; PF17827; PrmC_N; 1.
DR Pfam; PF01170; UPF0020; 1.
DR SUPFAM; SSF53335; S-adenosyl-L-methionine-dependent methyltransferases; 1.
DR PROSITE; PS00092; N6_MTASE; 1.
PE 4: Predicted;
KW Methyltransferase {ECO:0000256|ARBA:ARBA00022603,
KW ECO:0000313|EMBL:ETE70373.1};
KW Reference proteome {ECO:0000313|Proteomes:UP000018936};
KW S-adenosyl-L-methionine {ECO:0000256|ARBA:ARBA00022691};
KW Transferase {ECO:0000256|ARBA:ARBA00022679, ECO:0000313|EMBL:ETE70373.1}.
FT DOMAIN 70..140
FT /note="Release factor glutamine methyltransferase N-
FT terminal"
FT /evidence="ECO:0000259|Pfam:PF17827"
FT DOMAIN 190..249
FT /note="UPF0020"
FT /evidence="ECO:0000259|Pfam:PF01170"
FT NON_TER 1
FT /evidence="ECO:0000313|EMBL:ETE70373.1"
SQ SEQUENCE 371 AA; 42699 MW; 0B7CF176899149DC CRC64;
MALLAAELKR LPRAPEELFP LVHLISAIRR RLAVFPFYRM NRIEDTLLNP WHKLLRNYSY
YKANLVSAVD AVKYWQGVFE ANNIPEAQTS SEYIVSHVLG AKTNLNGNSI SAPLSAKQQK
EIQQLCAKRL QRMPVQYVLG EWDFQDLTLK MKPPELVSLI LDEERRKRLT SACSKVLQDF
PETRGPVILE SQLIAIDKLE AAVNLTKENA ERLHLQERIH IFHHDITSCP WECLQPWGLV
DTIISNPPYI FHEDMSDLAA EILCFEDLGA LDGGIDGMSI IKEILAMASY ILKDCGSVYL
EVDPRHPKMV TNWLSNHPDL FLFVSATHKD FYGKSWTKYC ILFFSLNTWS SKMTLVKLKK
SLEMYLHHEK I
//
