ID V8P9Y7_OPHHA Unreviewed; 641 AA.
AC V8P9Y7;
DT 19-FEB-2014, integrated into UniProtKB/TrEMBL.
DT 19-FEB-2014, sequence version 1.
DT 22-FEB-2023, entry version 22.
DE SubName: Full=Tumor necrosis factor receptor superfamily member 11A {ECO:0000313|EMBL:ETE71140.1};
DE Flags: Fragment;
GN Name=TNFRSF11A {ECO:0000313|EMBL:ETE71140.1};
GN ORFNames=L345_03042 {ECO:0000313|EMBL:ETE71140.1};
OS Ophiophagus hannah (King cobra) (Naja hannah).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Lepidosauria; Squamata; Bifurcata; Unidentata; Episquamata; Toxicofera;
OC Serpentes; Colubroidea; Elapidae; Elapinae; Ophiophagus.
OX NCBI_TaxID=8665 {ECO:0000313|EMBL:ETE71140.1, ECO:0000313|Proteomes:UP000018936};
RN [1] {ECO:0000313|EMBL:ETE71140.1, ECO:0000313|Proteomes:UP000018936}
RP NUCLEOTIDE SEQUENCE.
RC TISSUE=Blood {ECO:0000313|EMBL:ETE71140.1};
RX PubMed=24297900; DOI=10.1073/pnas.1314702110;
RA Vonk F.J., Casewell N.R., Henkel C.V., Heimberg A.M., Jansen H.J.,
RA McCleary R.J., Kerkkamp H.M., Vos R.A., Guerreiro I., Calvete J.J.,
RA Wuster W., Woods A.E., Logan J.M., Harrison R.A., Castoe T.A.,
RA de Koning A.P., Pollock D.D., Yandell M., Calderon D., Renjifo C.,
RA Currier R.B., Salgado D., Pla D., Sanz L., Hyder A.S., Ribeiro J.M.,
RA Arntzen J.W., van den Thillart G.E., Boetzer M., Pirovano W., Dirks R.P.,
RA Spaink H.P., Duboule D., McGlinn E., Kini R.M., Richardson M.K.;
RT "The king cobra genome reveals dynamic gene evolution and adaptation in the
RT snake venom system.";
RL Proc. Natl. Acad. Sci. U.S.A. 110:20651-20656(2013).
CC -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00206}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:ETE71140.1}.
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DR EMBL; AZIM01000423; ETE71140.1; -; Genomic_DNA.
DR AlphaFoldDB; V8P9Y7; -.
DR Proteomes; UP000018936; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR CDD; cd13411; TNFRSF11A; 1.
DR Gene3D; 2.10.50.10; Tumor Necrosis Factor Receptor, subunit A, domain 2; 2.
DR InterPro; IPR041648; RANK_CRD_2.
DR InterPro; IPR001368; TNFR/NGFR_Cys_rich_reg.
DR InterPro; IPR022361; TNFR_11A.
DR InterPro; IPR034040; TNFRSF11A_N.
DR PANTHER; PTHR47134; TUMOR NECROSIS FACTOR RECEPTOR SUPERFAMILY MEMBER 11A; 1.
DR PANTHER; PTHR47134:SF1; TUMOR NECROSIS FACTOR RECEPTOR SUPERFAMILY MEMBER 11A; 1.
DR Pfam; PF18278; RANK_CRD_2; 1.
DR Pfam; PF00020; TNFR_c6; 1.
DR PRINTS; PR01974; TNFACTORR11A.
DR SMART; SM00208; TNFR; 4.
DR SUPFAM; SSF57586; TNF receptor-like; 2.
DR PROSITE; PS00652; TNFR_NGFR_1; 1.
DR PROSITE; PS50050; TNFR_NGFR_2; 1.
PE 4: Predicted;
KW Disulfide bond {ECO:0000256|PROSITE-ProRule:PRU00206};
KW Membrane {ECO:0000256|SAM:Phobius}; Receptor {ECO:0000313|EMBL:ETE71140.1};
KW Reference proteome {ECO:0000313|Proteomes:UP000018936};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT TRANSMEM 192..215
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT REPEAT 16..51
FT /note="TNFR-Cys"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00206"
FT DOMAIN 16..51
FT /note="TNFR-Cys"
FT /evidence="ECO:0000259|PROSITE:PS50050"
FT REGION 461..517
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 609..641
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 466..486
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 495..517
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 616..630
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT DISULFID 30..43
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00206"
FT DISULFID 33..51
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00206"
FT NON_TER 1
FT /evidence="ECO:0000313|EMBL:ETE71140.1"
SQ SEQUENCE 641 AA; 70904 MW; EE2F73468A395EE6 CRC64;
MHSLGIPKLY LQVKPSCSSE QQYEYSGRCC TKCEPGKYMA KKCTVFSETV CKPCGSNEYM
DIWNEEEKCF LHKICDRGKA LIEVIPGNST FQRQCACTAG YHWNRDCDCC RRNTKCSPGS
GVKFPIQQDK NTVCVPCPTG YFSNVSSATD ACKAWTNCTA LGTEEKIPGN NWSDAVCKIQ
EKTHSEDENK KLFYVLIVPF FLIALAGVII LTVYYRSKGK LLTADLQYWA QEICQQIKGK
KDSSCDTFVN TNVAHPAGHQ LLGETYLLDL DQYGFPEEVH HPCEHLLSEK DGPDQILYGS
RENFPALFLT TTSEDGHFRQ MPTEDEYTDK VSHGQCYLPL VSQSDSKPAS PFSEPLEVGE
NDSLNYFFTG TENLEELVHC CCLDTSCAMD PIHASSHKYL QSSCNHFTCA KMRNVDNEDA
GTSLLLSKEK HSFARSSCRQ PRNKLDNATD SLKENGSALL GTFGLESSPE DQNGSANNVG
DQSDSSDGKD QNTKRTSESN YNVSDPPAAS GNVTGNGNST FISSGQVMNF KGEIIFVYVS
QNSQEGSMTP GSSDDSLGNP VQEENLNRCE TFAGNADQYK EKCAEINTCH SMESGEPQST
VEGYKRTFGP IGQEENCESQ KKHLSHEASQ PIQEEGKPGY S
//
