ID V8PHC3_OPHHA Unreviewed; 1222 AA.
AC V8PHC3;
DT 19-FEB-2014, integrated into UniProtKB/TrEMBL.
DT 19-FEB-2014, sequence version 1.
DT 27-MAR-2024, entry version 40.
DE SubName: Full=Peroxidasin-like protein {ECO:0000313|EMBL:ETE73745.1};
DE Flags: Fragment;
GN Name=Pxdn {ECO:0000313|EMBL:ETE73745.1};
GN ORFNames=L345_00420 {ECO:0000313|EMBL:ETE73745.1};
OS Ophiophagus hannah (King cobra) (Naja hannah).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Lepidosauria; Squamata; Bifurcata; Unidentata; Episquamata; Toxicofera;
OC Serpentes; Colubroidea; Elapidae; Elapinae; Ophiophagus.
OX NCBI_TaxID=8665 {ECO:0000313|EMBL:ETE73745.1, ECO:0000313|Proteomes:UP000018936};
RN [1] {ECO:0000313|EMBL:ETE73745.1, ECO:0000313|Proteomes:UP000018936}
RP NUCLEOTIDE SEQUENCE.
RC TISSUE=Blood {ECO:0000313|EMBL:ETE73745.1};
RX PubMed=24297900; DOI=10.1073/pnas.1314702110;
RA Vonk F.J., Casewell N.R., Henkel C.V., Heimberg A.M., Jansen H.J.,
RA McCleary R.J., Kerkkamp H.M., Vos R.A., Guerreiro I., Calvete J.J.,
RA Wuster W., Woods A.E., Logan J.M., Harrison R.A., Castoe T.A.,
RA de Koning A.P., Pollock D.D., Yandell M., Calderon D., Renjifo C.,
RA Currier R.B., Salgado D., Pla D., Sanz L., Hyder A.S., Ribeiro J.M.,
RA Arntzen J.W., van den Thillart G.E., Boetzer M., Pirovano W., Dirks R.P.,
RA Spaink H.P., Duboule D., McGlinn E., Kini R.M., Richardson M.K.;
RT "The king cobra genome reveals dynamic gene evolution and adaptation in the
RT snake venom system.";
RL Proc. Natl. Acad. Sci. U.S.A. 110:20651-20656(2013).
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:ETE73745.1}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; AZIM01000047; ETE73745.1; -; Genomic_DNA.
DR AlphaFoldDB; V8PHC3; -.
DR Proteomes; UP000018936; Unassembled WGS sequence.
DR GO; GO:0005576; C:extracellular region; IEA:UniProtKB-KW.
DR GO; GO:0020037; F:heme binding; IEA:InterPro.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0004601; F:peroxidase activity; IEA:InterPro.
DR GO; GO:0006979; P:response to oxidative stress; IEA:InterPro.
DR CDD; cd05745; Ig3_Peroxidasin; 1.
DR CDD; cd05746; Ig4_Peroxidasin; 1.
DR CDD; cd09826; peroxidasin_like; 1.
DR Gene3D; 6.20.200.20; -; 1.
DR Gene3D; 1.10.640.10; Haem peroxidase domain superfamily, animal type; 1.
DR Gene3D; 2.60.40.10; Immunoglobulins; 4.
DR InterPro; IPR019791; Haem_peroxidase_animal.
DR InterPro; IPR010255; Haem_peroxidase_sf.
DR InterPro; IPR037120; Haem_peroxidase_sf_animal.
DR InterPro; IPR007110; Ig-like_dom.
DR InterPro; IPR036179; Ig-like_dom_sf.
DR InterPro; IPR013783; Ig-like_fold.
DR InterPro; IPR013098; Ig_I-set.
DR InterPro; IPR003599; Ig_sub.
DR InterPro; IPR003598; Ig_sub2.
DR InterPro; IPR047018; Peroxidasin_Ig-like3.
DR InterPro; IPR034828; Peroxidasin_Ig-like4.
DR InterPro; IPR034824; Peroxidasin_peroxidase.
DR InterPro; IPR001007; VWF_dom.
DR PANTHER; PTHR11475; OXIDASE/PEROXIDASE; 1.
DR PANTHER; PTHR11475:SF75; PEROXIDASIN HOMOLOG; 1.
DR Pfam; PF03098; An_peroxidase; 1.
DR Pfam; PF07679; I-set; 4.
DR Pfam; PF00093; VWC; 1.
DR PRINTS; PR00457; ANPEROXIDASE.
DR SMART; SM00409; IG; 4.
DR SMART; SM00408; IGc2; 4.
DR SMART; SM00214; VWC; 1.
DR SUPFAM; SSF57603; FnI-like domain; 1.
DR SUPFAM; SSF48113; Heme-dependent peroxidases; 1.
DR SUPFAM; SSF48726; Immunoglobulin; 4.
DR PROSITE; PS50835; IG_LIKE; 4.
DR PROSITE; PS50292; PEROXIDASE_3; 1.
DR PROSITE; PS01208; VWFC_1; 1.
DR PROSITE; PS50184; VWFC_2; 1.
PE 4: Predicted;
KW Coiled coil {ECO:0000256|SAM:Coils};
KW Heme {ECO:0000256|PIRSR:PIRSR619791-2};
KW Iron {ECO:0000256|PIRSR:PIRSR619791-2};
KW Metal-binding {ECO:0000256|PIRSR:PIRSR619791-2};
KW Oxidoreductase {ECO:0000256|ARBA:ARBA00023002};
KW Reference proteome {ECO:0000313|Proteomes:UP000018936};
KW Secreted {ECO:0000256|ARBA:ARBA00022525}.
FT DOMAIN 19..105
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 117..189
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 194..281
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 282..371
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 1154..1212
FT /note="VWFC"
FT /evidence="ECO:0000259|PROSITE:PS50184"
FT REGION 1..28
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 1130..1157
FT /evidence="ECO:0000256|SAM:Coils"
FT BINDING 815
FT /ligand="heme b"
FT /ligand_id="ChEBI:CHEBI:60344"
FT /ligand_part="Fe"
FT /ligand_part_id="ChEBI:CHEBI:18248"
FT /note="axial binding residue"
FT /evidence="ECO:0000256|PIRSR:PIRSR619791-2"
FT NON_TER 1
FT /evidence="ECO:0000313|EMBL:ETE73745.1"
SQ SEQUENCE 1222 AA; 136949 MW; 47E208C53B346147 CRC64;
MRRLQPHVNI QGGSREERPR ITSEPQDVDV TSGNTVYFTC RAEGNPKPEI IWLRNNNELS
MKADSRLNLL DDGTLMIQNT RETDQGIYQC MAKNIAGEVK TQEVTLRYFG SPEVLVGESV
TLECSATGHP QPRITWTKGD RTPLPNDPRI TITPSGGLYI QNVEQEEGGE YTCFATNSLD
SIHATAFIIV QAVPQFTVTP QDRSVIEGQT VDFPCEAQGY PQPVIAWTKG GSQLSVDRRH
LVLSSGTLRI STVALHDQGQ YECQAVNIVG SQRVAVHLNV QPRVTPVFAN VPSDMTVEVG
TNVQIPCSSQ GEPEPIITWN KDGVQVTESG KFHVSSEGFL TIRDVGPADQ GRYECVARNT
IGYSSVSMVL TVNVPDVSRN GDPFVASSIV EAIATVDRAI NSTRTHLFDS RPRSPNDLLA
LFRYPRDPYT IEQARAGEIF ERTLQLIQEH VQDGLMVDLN GTSCTAHRRV NNCSDMCYHQ
KYRTHDGTCN NLQHPMWGAS LTAFERMLKS VYENGFNLPR GIGPNRHYNG HTLPMPRLVS
TTLIGTETIT PDDQFSHMLM QWGQFLDHDL DSTVAALSEA RFSDGQHCSS VCTNDPPCFS
IMIPPNDPRV RNGARCMFFV RSSPVCGSGM TSLLMNSVYP REQINQLTSY IDASNVYGSS
EHEAQEVRDL ASHRGLLRQG IVQRSGKPLL PFATGPPTEC MRDENESPIP CFLAGDHRAN
EQLGLTSMHT LWFREHNRIA TELLKLNPHW DGDTIYHETR KIVGAEMQHI TYSHWLPKIL
GVVGLKMLGE YKGYDPNVNS GITNEFATAA FRFGHTLINP VLYRLDENFE TIPQGPISLH
KAFFSPFRIV NEGGIDPLLR GLFGTAGKMR VTSQLLNTEL TERLFSMARA VALDLAAMNI
QRGRDHGIPP YHEFRVYCNL SSTHTFEDLK NEIKNPEIRE KLKRLYGSPL NIDLFPALIL
EDLVPGSRLG PTLMCLLSTQ FKRLRDGDRL WYENPGVFSP AQLTQIKQSS LARVLCDNGD
NITRVQRDVF RVAEFPHGYG SCAEVPKVDL RMWQDCCEDC RTRGQFNAFS YHFRGRRSLD
YSFREDKPSK YLKIPRASSF TRGNTFFNST TSSFDEHKKA PIMNDFKEFV GDMQKTITDL
RKQIKKLESR LSRTECTDEN GKSYSSNDTW KKDPCTTCEC KVGQVTCYVE SCPSLDCATP
VKLKGICCPV CLKQTVSKGN AP
//