ID V8PHH1_OPHHA Unreviewed; 1222 AA.
AC V8PHH1;
DT 19-FEB-2014, integrated into UniProtKB/TrEMBL.
DT 19-FEB-2014, sequence version 1.
DT 24-JAN-2024, entry version 25.
DE RecName: Full=Acylamino-acid-releasing enzyme {ECO:0000256|ARBA:ARBA00018421};
DE EC=3.4.19.1 {ECO:0000256|ARBA:ARBA00012917};
DE Flags: Fragment;
GN Name=Apeh {ECO:0000313|EMBL:ETE73342.1};
GN ORFNames=L345_00820 {ECO:0000313|EMBL:ETE73342.1};
OS Ophiophagus hannah (King cobra) (Naja hannah).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Lepidosauria; Squamata; Bifurcata; Unidentata; Episquamata; Toxicofera;
OC Serpentes; Colubroidea; Elapidae; Elapinae; Ophiophagus.
OX NCBI_TaxID=8665 {ECO:0000313|EMBL:ETE73342.1, ECO:0000313|Proteomes:UP000018936};
RN [1] {ECO:0000313|EMBL:ETE73342.1, ECO:0000313|Proteomes:UP000018936}
RP NUCLEOTIDE SEQUENCE.
RC TISSUE=Blood {ECO:0000313|EMBL:ETE73342.1};
RX PubMed=24297900; DOI=10.1073/pnas.1314702110;
RA Vonk F.J., Casewell N.R., Henkel C.V., Heimberg A.M., Jansen H.J.,
RA McCleary R.J., Kerkkamp H.M., Vos R.A., Guerreiro I., Calvete J.J.,
RA Wuster W., Woods A.E., Logan J.M., Harrison R.A., Castoe T.A.,
RA de Koning A.P., Pollock D.D., Yandell M., Calderon D., Renjifo C.,
RA Currier R.B., Salgado D., Pla D., Sanz L., Hyder A.S., Ribeiro J.M.,
RA Arntzen J.W., van den Thillart G.E., Boetzer M., Pirovano W., Dirks R.P.,
RA Spaink H.P., Duboule D., McGlinn E., Kini R.M., Richardson M.K.;
RT "The king cobra genome reveals dynamic gene evolution and adaptation in the
RT snake venom system.";
RL Proc. Natl. Acad. Sci. U.S.A. 110:20651-20656(2013).
CC -!- CATALYTIC ACTIVITY:
CC Reaction=Cleavage of an N-acetyl or N-formyl amino acid from the N-
CC terminus of a polypeptide.; EC=3.4.19.1;
CC Evidence={ECO:0000256|ARBA:ARBA00000721};
CC -!- SUBUNIT: Homotetramer. {ECO:0000256|ARBA:ARBA00011881}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|ARBA:ARBA00004496}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:ETE73342.1}.
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DR EMBL; AZIM01000105; ETE73342.1; -; Genomic_DNA.
DR AlphaFoldDB; V8PHH1; -.
DR Proteomes; UP000018936; Unassembled WGS sequence.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0008236; F:serine-type peptidase activity; IEA:InterPro.
DR GO; GO:0006508; P:proteolysis; IEA:InterPro.
DR Gene3D; 3.40.50.1820; alpha/beta hydrolase; 2.
DR Gene3D; 2.120.10.30; TolB, C-terminal domain; 1.
DR InterPro; IPR011042; 6-blade_b-propeller_TolB-like.
DR InterPro; IPR045550; AARE_N.
DR InterPro; IPR029058; AB_hydrolase.
DR InterPro; IPR001375; Peptidase_S9.
DR PANTHER; PTHR42776:SF4; ACYLAMINO-ACID-RELEASING ENZYME; 1.
DR PANTHER; PTHR42776; SERINE PEPTIDASE S9 FAMILY MEMBER; 1.
DR Pfam; PF19283; APEH_N; 2.
DR Pfam; PF00326; Peptidase_S9; 2.
DR SUPFAM; SSF53474; alpha/beta-Hydrolases; 2.
DR SUPFAM; SSF50993; Peptidase/esterase 'gauge' domain; 1.
PE 4: Predicted;
KW Cytoplasm {ECO:0000256|ARBA:ARBA00022490};
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW Reference proteome {ECO:0000313|Proteomes:UP000018936}.
FT DOMAIN 56..325
FT /note="Acylamino-acid-releasing enzyme N-terminal"
FT /evidence="ECO:0000259|Pfam:PF19283"
FT DOMAIN 561..741
FT /note="Peptidase S9 prolyl oligopeptidase catalytic"
FT /evidence="ECO:0000259|Pfam:PF00326"
FT DOMAIN 754..866
FT /note="Acylamino-acid-releasing enzyme N-terminal"
FT /evidence="ECO:0000259|Pfam:PF19283"
FT DOMAIN 1014..1221
FT /note="Peptidase S9 prolyl oligopeptidase catalytic"
FT /evidence="ECO:0000259|Pfam:PF00326"
FT NON_TER 1
FT /evidence="ECO:0000313|EMBL:ETE73342.1"
SQ SEQUENCE 1222 AA; 136694 MW; 17B538C272F17A21 CRC64;
MNEVGLSWQV ASIWPIHSVH PGFRDSAGQF HLNVQKDKYI LSVALLPFML LNDTEEIAAL
YRDLSQYPSL SHACIGPEVT TQYGGKHCNI YTEWSQRDLE RAENVKFCRQ YLVFHDNQSV
IYSGPSGNCT EVKGELLSRD SPSGTQKAVV RKMCNSKGEE KQFLEVWEKN RKVKSIELSA
LEKHGQVYDD DQFGCLAWSH SETHLLYVAE KKRPKTESFF KHRAPELNTE EELAKTERDK
AGEQFVFYED WGETLVAKSI PVLCVLDIES NNVSVLEGVP EYISPGQAFW TPDDTGVVFT
GWYHEPFRLG LKYCINRRSS LFHVDLTGGQ CELLSDDNKA IWSPRLSPDQ CRIVYLENQA
SGPHQQCSRI CMYDWYTKLT SVIVDIVPRQ IQDGFAGIYS TALPEHCWAA DSQRVVLDTT
QRSRQELIVV DMASKSVCSL TKGSSLGSWV LLTIDRDLMV ARFSTPNSPP MLMVAFLPPA
GKEADVNWVC LEETSPIQGI SWDVHILQPS PEQDNPQYRG LDFEAILLKP TQVPEQTKLP
LVVSPHGGPH SVFTTTWMLY PAVLCQMGFA VLLVNYRGSL GFGQDSVDSL PGNVGCQDVN
DVQFCVEQML QKEPLDSKRV ALLGGSHGGF LSCHLIGQYP GTYKACVTRN PVVNMASMIG
STDIPDWCMT EVGLPYDQAA LPVPEQWEKM LLHSPMQFVD KVQAPVLLLI GEEDRRVPPK
QGLEYYRALR SRGIPTRIQV ITMHYPVWRL RQTVWSNSGR VRNINLTALD KHGKVYTDEQ
FRCFAWSNSE TQIVYVAERK HSPKQQFFSQ EEFTEGQENE RFVYNDNWGE ALGDKSVPVL
CVLNIETTKV SVLEDIPGHL SPGQVFMGFT QEHCPCFAGP LTIKESYLAL LREVESWTLL
GVQQDLLVVS CSSPSCPPSL KVGVLPSEGS ELELQWISVE ESSVLPDMEW KILTVDPALS
EKGSPYTDQS FEAILLIPRG SKQGEEALFP LVVSPHGGPH SVFDACWRPT MAGLCRLGFA
VLMVNYRGSL GFGQDSIDSL ISHVGVQDVA DTQLAVEVAL QMKCLDPNRI ALLGGSHGGF
ICCHLIGRFP EMYKACAVRN SVTNMATLLG TSDIPDWRYA SLGLPYSYER IPTEKDLAAM
LLSSPITHAT KVQAPVLLCV GAKDRQVSPS QALEYYRVLK ARGIPVRLMW YPEENHALSG
VVAEADVFMN CAQWITHHLS KT
//