ID V8PIM7_OPHHA Unreviewed; 380 AA.
AC V8PIM7;
DT 19-FEB-2014, integrated into UniProtKB/TrEMBL.
DT 19-FEB-2014, sequence version 1.
DT 22-FEB-2023, entry version 34.
DE RecName: Full=Cytoplasmic protein {ECO:0000256|PIRNR:PIRNR037874};
GN Name=NCK2 {ECO:0000313|EMBL:ETE73868.1};
GN ORFNames=L345_00291 {ECO:0000313|EMBL:ETE73868.1};
OS Ophiophagus hannah (King cobra) (Naja hannah).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Lepidosauria; Squamata; Bifurcata; Unidentata; Episquamata; Toxicofera;
OC Serpentes; Colubroidea; Elapidae; Elapinae; Ophiophagus.
OX NCBI_TaxID=8665 {ECO:0000313|EMBL:ETE73868.1, ECO:0000313|Proteomes:UP000018936};
RN [1] {ECO:0000313|EMBL:ETE73868.1, ECO:0000313|Proteomes:UP000018936}
RP NUCLEOTIDE SEQUENCE.
RC TISSUE=Blood {ECO:0000313|EMBL:ETE73868.1};
RX PubMed=24297900; DOI=10.1073/pnas.1314702110;
RA Vonk F.J., Casewell N.R., Henkel C.V., Heimberg A.M., Jansen H.J.,
RA McCleary R.J., Kerkkamp H.M., Vos R.A., Guerreiro I., Calvete J.J.,
RA Wuster W., Woods A.E., Logan J.M., Harrison R.A., Castoe T.A.,
RA de Koning A.P., Pollock D.D., Yandell M., Calderon D., Renjifo C.,
RA Currier R.B., Salgado D., Pla D., Sanz L., Hyder A.S., Ribeiro J.M.,
RA Arntzen J.W., van den Thillart G.E., Boetzer M., Pirovano W., Dirks R.P.,
RA Spaink H.P., Duboule D., McGlinn E., Kini R.M., Richardson M.K.;
RT "The king cobra genome reveals dynamic gene evolution and adaptation in the
RT snake venom system.";
RL Proc. Natl. Acad. Sci. U.S.A. 110:20651-20656(2013).
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|PIRNR:PIRNR037874}.
CC Endoplasmic reticulum {ECO:0000256|PIRNR:PIRNR037874}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:ETE73868.1}.
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DR EMBL; AZIM01000026; ETE73868.1; -; Genomic_DNA.
DR AlphaFoldDB; V8PIM7; -.
DR Proteomes; UP000018936; Unassembled WGS sequence.
DR GO; GO:0005829; C:cytosol; IEA:UniProtKB-UniRule.
DR GO; GO:0005783; C:endoplasmic reticulum; IEA:UniProtKB-SubCell.
DR GO; GO:0030838; P:positive regulation of actin filament polymerization; IEA:UniProtKB-UniRule.
DR GO; GO:0006417; P:regulation of translation; IEA:UniProtKB-KW.
DR CDD; cd10409; SH2_Nck2; 1.
DR CDD; cd11899; SH3_Nck2_1; 1.
DR CDD; cd11902; SH3_Nck2_2; 1.
DR CDD; cd11903; SH3_Nck2_3; 1.
DR Gene3D; 3.30.505.10; SH2 domain; 1.
DR Gene3D; 2.30.30.40; SH3 Domains; 3.
DR InterPro; IPR017304; NCK.
DR InterPro; IPR035883; Nck2_SH2.
DR InterPro; IPR035559; Nck2_SH3_1.
DR InterPro; IPR035560; Nck2_SH3_2.
DR InterPro; IPR035561; Nck2_SH3_3.
DR InterPro; IPR000980; SH2.
DR InterPro; IPR036860; SH2_dom_sf.
DR InterPro; IPR036028; SH3-like_dom_sf.
DR InterPro; IPR001452; SH3_domain.
DR PANTHER; PTHR19969:SF12; CYTOPLASMIC PROTEIN NCK2; 1.
DR PANTHER; PTHR19969; SH2-SH3 ADAPTOR PROTEIN-RELATED; 1.
DR Pfam; PF00017; SH2; 1.
DR Pfam; PF00018; SH3_1; 2.
DR Pfam; PF14604; SH3_9; 1.
DR PIRSF; PIRSF037874; Cytoplasmic_NCK; 1.
DR PRINTS; PR00401; SH2DOMAIN.
DR PRINTS; PR00452; SH3DOMAIN.
DR SMART; SM00252; SH2; 1.
DR SMART; SM00326; SH3; 3.
DR SUPFAM; SSF55550; SH2 domain; 1.
DR SUPFAM; SSF50044; SH3-domain; 3.
DR PROSITE; PS50001; SH2; 1.
DR PROSITE; PS50002; SH3; 3.
PE 4: Predicted;
KW Cytoplasm {ECO:0000256|PIRNR:PIRNR037874};
KW Endoplasmic reticulum {ECO:0000256|PIRNR:PIRNR037874};
KW Reference proteome {ECO:0000313|Proteomes:UP000018936};
KW SH2 domain {ECO:0000256|PROSITE-ProRule:PRU00191};
KW SH3 domain {ECO:0000256|ARBA:ARBA00022443, ECO:0000256|PROSITE-
KW ProRule:PRU00192}; Translation regulation {ECO:0000256|PIRNR:PIRNR037874}.
FT DOMAIN 2..61
FT /note="SH3"
FT /evidence="ECO:0000259|PROSITE:PS50002"
FT DOMAIN 111..170
FT /note="SH3"
FT /evidence="ECO:0000259|PROSITE:PS50002"
FT DOMAIN 195..257
FT /note="SH3"
FT /evidence="ECO:0000259|PROSITE:PS50002"
FT DOMAIN 285..379
FT /note="SH2"
FT /evidence="ECO:0000259|PROSITE:PS50001"
FT REGION 79..102
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 87..102
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 380 AA; 43070 MW; D05BE044E8269E83 CRC64;
MTEEVIVIAK WDYTAQQDQE LDIKKNERLW LLDDSKTWWR VRNTANKTGY VPSNYVERKN
SLKKGSLVKN LKDTLGLGKT KRKTSARDAS PTPSTDAEYP SNGSSADRIY DLNIPAYVKF
AYVAEREDEL SLVKGSRVIV MEKCSDGWWR GSYNGHIGWF PSNYVVEEVE EATADSPSFL
SLRKGASMSN GQAMKILHIV QTLYPFSSVT EEELNFEKGE TMEVIEKPEN DPEWWKCKNS
RGQIGLVPKN YVVILSDGPT INTSHPPQIS YTGPSSTGRF AGKEWYYGNV TRHQAECALN
ERGSEGDFLV RDSESSPSDF SVSLKASGKN KHFKVQLVDN VYCIGQRRFN TMDELVEHYK
KAPIFTSEHG EKLYLVKALQ
//
