ID V9DBW2_9EURO Unreviewed; 676 AA.
AC V9DBW2;
DT 19-FEB-2014, integrated into UniProtKB/TrEMBL.
DT 19-FEB-2014, sequence version 1.
DT 27-MAR-2024, entry version 32.
DE RecName: Full=Lysophospholipase {ECO:0000256|ARBA:ARBA00013274, ECO:0000256|RuleBase:RU362103};
DE EC=3.1.1.5 {ECO:0000256|ARBA:ARBA00013274, ECO:0000256|RuleBase:RU362103};
GN ORFNames=G647_05254 {ECO:0000313|EMBL:ETI23452.1};
OS Cladophialophora carrionii CBS 160.54.
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC Chaetothyriomycetidae; Chaetothyriales; Herpotrichiellaceae;
OC Cladophialophora.
OX NCBI_TaxID=1279043 {ECO:0000313|EMBL:ETI23452.1, ECO:0000313|Proteomes:UP000030678};
RN [1] {ECO:0000313|EMBL:ETI23452.1, ECO:0000313|Proteomes:UP000030678}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=CBS 160.54 {ECO:0000313|EMBL:ETI23452.1,
RC ECO:0000313|Proteomes:UP000030678};
RG The Broad Institute Genomics Platform;
RA Cuomo C., de Hoog S., Gorbushina A., Walker B., Young S.K., Zeng Q.,
RA Gargeya S., Fitzgerald M., Haas B., Abouelleil A., Allen A.W., Alvarado L.,
RA Arachchi H.M., Berlin A.M., Chapman S.B., Gainer-Dewar J., Goldberg J.,
RA Griggs A., Gujja S., Hansen M., Howarth C., Imamovic A., Ireland A.,
RA Larimer J., McCowan C., Murphy C., Pearson M., Poon T.W., Priest M.,
RA Roberts A., Saif S., Shea T., Sisk P., Sykes S., Wortman J., Nusbaum C.,
RA Birren B.;
RT "The Genome Sequence of Cladophialophora carrionii CBS 160.54.";
RL Submitted (MAR-2013) to the EMBL/GenBank/DDBJ databases.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=a 1-acyl-sn-glycero-3-phosphocholine + H2O = a fatty acid +
CC H(+) + sn-glycerol 3-phosphocholine; Xref=Rhea:RHEA:15177,
CC ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:16870,
CC ChEBI:CHEBI:28868, ChEBI:CHEBI:58168; EC=3.1.1.5;
CC Evidence={ECO:0000256|ARBA:ARBA00000960,
CC ECO:0000256|RuleBase:RU362103};
CC -!- SIMILARITY: Belongs to the lysophospholipase family.
CC {ECO:0000256|ARBA:ARBA00008780, ECO:0000256|RuleBase:RU362103}.
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DR EMBL; KB822705; ETI23452.1; -; Genomic_DNA.
DR RefSeq; XP_008727807.1; XM_008729585.1.
DR AlphaFoldDB; V9DBW2; -.
DR GeneID; 19983747; -.
DR VEuPathDB; FungiDB:G647_05254; -.
DR HOGENOM; CLU_013227_0_0_1; -.
DR OrthoDB; 1997175at2759; -.
DR Proteomes; UP000030678; Unassembled WGS sequence.
DR GO; GO:0004622; F:lysophospholipase activity; IEA:UniProtKB-EC.
DR GO; GO:0102545; F:phosphatidyl phospholipase B activity; IEA:UniProtKB-EC.
DR GO; GO:0009395; P:phospholipid catabolic process; IEA:InterPro.
DR Gene3D; 3.40.1090.10; Cytosolic phospholipase A2 catalytic domain; 1.
DR InterPro; IPR016035; Acyl_Trfase/lysoPLipase.
DR InterPro; IPR002642; LysoPLipase_cat_dom.
DR PANTHER; PTHR10728; CYTOSOLIC PHOSPHOLIPASE A2; 1.
DR PANTHER; PTHR10728:SF40; LYSOPHOSPHOLIPASE; 1.
DR Pfam; PF01735; PLA2_B; 2.
DR SMART; SM00022; PLAc; 1.
DR SUPFAM; SSF52151; FabD/lysophospholipase-like; 1.
DR PROSITE; PS51210; PLA2C; 1.
PE 3: Inferred from homology;
KW Hydrolase {ECO:0000256|PROSITE-ProRule:PRU00555,
KW ECO:0000256|RuleBase:RU362103};
KW Lipid degradation {ECO:0000256|ARBA:ARBA00022963, ECO:0000256|PROSITE-
KW ProRule:PRU00555};
KW Lipid metabolism {ECO:0000256|PROSITE-ProRule:PRU00555,
KW ECO:0000256|RuleBase:RU362103}.
FT DOMAIN 83..676
FT /note="PLA2c"
FT /evidence="ECO:0000259|PROSITE:PS51210"
FT REGION 1..34
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1..21
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 676 AA; 74747 MW; 100C312F80F644E9 CRC64;
MPDRGGEDGR DGKDEDGHER PSSSPSAGSS GARAKVKGKL KSFWNKTVVP AFPEAIADIS
IIKAALKVEA TITKDLRDTS RHPEVAQSAT VRRGFELAPE EMRFRDVRKV KVRDAFCRYL
GLDPAEVHVD DVPIVAFGGS GGGYRAMIGM LGYGDEMKRT GLWDVLTYVS GVSGSCWSLA
AYYTWAGTSM DAVIRHCKQR LHPHHPLSPE AIREVLHAPG GPSKTLGPLV QKHRTGLSTV
AMDLYSVFTT GHLFLVHDPA LEPPGSHGRS GVKKEVAGQH EQWFKWSSAN AHLVDGQEPL
PILTAIRHER PWKDWVDQEH PFKDADPGAK EHEEAQDAWF NWFEISPIEV GCDELEAWCP
TWAFGRPFEK GRDTMQIPEQ SLALLLGLCT SAPAGPLTSY LATIKRSLPS GFIGNSINDM
AKGVARMWGE KGTEEFQAHH PLHAVNEHNF MFHLSKGENK DTPSPPIENS PRIHLIDSGM
DNNCPTYVML HPRRNVDVIL NMDASSDVLK GTFQDRVDQI ASRRCLKFSK RYPELQAGTD
PKNPDQFQGL YAQIYDGSIL VDRPEEVVDS YGHTVTNPPA PPCLHESTMI YLPLLPNQGA
VPDFDPSTAK FSGSYNLVWT PDQVEMLVRI CCANFKAGEE TIKMVLREQW LKKRAKRETA
AASVLPLADS PGEACA
//
