ID V9FDX8_PHYPR Unreviewed; 3658 AA.
AC V9FDX8;
DT 19-FEB-2014, integrated into UniProtKB/TrEMBL.
DT 19-FEB-2014, sequence version 1.
DT 27-MAR-2024, entry version 41.
DE SubName: Full=Uncharacterized protein {ECO:0000313|EMBL:ETI49669.1};
GN ORFNames=F443_06490 {ECO:0000313|EMBL:ETI49669.1};
OS Phytophthora parasitica P1569.
OC Eukaryota; Sar; Stramenopiles; Oomycota; Peronosporales; Peronosporaceae;
OC Phytophthora.
OX NCBI_TaxID=1317065 {ECO:0000313|EMBL:ETI49669.1, ECO:0000313|Proteomes:UP000018721};
RN [1] {ECO:0000313|EMBL:ETI49669.1, ECO:0000313|Proteomes:UP000018721}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=P1569 {ECO:0000313|EMBL:ETI49669.1,
RC ECO:0000313|Proteomes:UP000018721};
RG The Broad Institute Genomics Platform;
RA Russ C., Tyler B., Panabieres F., Shan W., Tripathy S., Grunwald N.,
RA Machado M., Johnson C.S., Arredondo F., Hong C., Coffey M., Young S.K.,
RA Zeng Q., Gargeya S., Fitzgerald M., Abouelleil A., Alvarado L.,
RA Chapman S.B., Gainer-Dewar J., Goldberg J., Griggs A., Gujja S., Hansen M.,
RA Howarth C., Imamovic A., Ireland A., Larimer J., McCowan C., Murphy C.,
RA Pearson M., Poon T.W., Priest M., Roberts A., Saif S., Shea T., Sykes S.,
RA Wortman J., Nusbaum C., Birren B.;
RT "The Genome Sequence of Phytophthora parasitica P1569.";
RL Submitted (NOV-2013) to the EMBL/GenBank/DDBJ databases.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:ETI49669.1}.
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DR EMBL; ANIZ01001092; ETI49669.1; -; Genomic_DNA.
DR EMBL; ANIZ01001092; ETI49670.1; -; Genomic_DNA.
DR EMBL; ANIZ01001092; ETI49671.1; -; Genomic_DNA.
DR EnsemblProtists; ETI49669; ETI49669; F443_06490.
DR EnsemblProtists; ETI49670; ETI49670; F443_06490.
DR EnsemblProtists; ETI49671; ETI49671; F443_06490.
DR OrthoDB; 8448at2759; -.
DR Proteomes; UP000018721; Unassembled WGS sequence.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0004677; F:DNA-dependent protein kinase activity; IEA:InterPro.
DR GO; GO:0006303; P:double-strand break repair via nonhomologous end joining; IEA:InterPro.
DR CDD; cd05172; PIKKc_DNA-PK; 1.
DR Gene3D; 1.25.10.10; Leucine-rich Repeat Variant; 1.
DR Gene3D; 1.10.1070.11; Phosphatidylinositol 3-/4-kinase, catalytic domain; 1.
DR InterPro; IPR011989; ARM-like.
DR InterPro; IPR016024; ARM-type_fold.
DR InterPro; IPR037706; DNA-PK_dom.
DR InterPro; IPR046804; DNA-PKcs_N.
DR InterPro; IPR046803; DNAPKcs_CC1-2.
DR InterPro; IPR012582; DNAPKcs_CC3.
DR InterPro; IPR045581; DNAPKcs_CC5.
DR InterPro; IPR003152; FATC_dom.
DR InterPro; IPR011009; Kinase-like_dom_sf.
DR InterPro; IPR000403; PI3/4_kinase_cat_dom.
DR InterPro; IPR036940; PI3/4_kinase_cat_sf.
DR PANTHER; PTHR11139; ATAXIA TELANGIECTASIA MUTATED ATM -RELATED; 1.
DR PANTHER; PTHR11139:SF68; DNA-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT; 1.
DR Pfam; PF20500; DNA-PKcs_N; 1.
DR Pfam; PF20502; DNAPKcs_CC1-2; 1.
DR Pfam; PF08163; DNAPKcs_CC3; 1.
DR Pfam; PF19704; DNAPKcs_CC5; 2.
DR Pfam; PF00454; PI3_PI4_kinase; 1.
DR SMART; SM01343; FATC; 1.
DR SMART; SM01344; NUC194; 1.
DR SMART; SM00146; PI3Kc; 1.
DR SUPFAM; SSF48371; ARM repeat; 2.
DR SUPFAM; SSF56112; Protein kinase-like (PK-like); 1.
DR PROSITE; PS51190; FATC; 1.
DR PROSITE; PS50290; PI3_4_KINASE_3; 1.
PE 4: Predicted;
KW DNA damage {ECO:0000256|ARBA:ARBA00022763};
KW DNA repair {ECO:0000256|ARBA:ARBA00023204};
KW Kinase {ECO:0000256|ARBA:ARBA00022527};
KW Phosphoprotein {ECO:0000256|ARBA:ARBA00022553};
KW Reference proteome {ECO:0000313|Proteomes:UP000018721};
KW Serine/threonine-protein kinase {ECO:0000256|ARBA:ARBA00022527};
KW Transferase {ECO:0000256|ARBA:ARBA00022527}.
FT DOMAIN 3223..3560
FT /note="PI3K/PI4K catalytic"
FT /evidence="ECO:0000259|PROSITE:PS50290"
FT DOMAIN 3626..3658
FT /note="FATC"
FT /evidence="ECO:0000259|PROSITE:PS51190"
FT REGION 3528..3566
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 3658 AA; 408540 MW; C0895A90A43CF4E9 CRC64;
MTAFAVQCLG WLASSIYVYL GAKGYGKIED KLKTFGESLL ALDTKVTAWR WPLFSQYVQC
IGQFVQERHG VPLDEGYVKF LGDMLCHVMA AYPQCLWKSK VVVHKSIAAV FAALSNWTVI
DPLVDRFVLH TLILSISNIT DSEVIIYHPD TGELVTNLLY EYESFWLAML GRCTEMAAEP
TLVAMKTGSD DVEMKEPSDV GRSLQTIIFD STVKHVLGII GQLNLSYQFD LQTTNNGKNA
TGYLVRCAAL RSFTCCLYDM SFYAQPQPTV PRDHSIMLNM TEFVERVLGQ VLRPLLRPWI
PLIMQRVMSS ASKLPLVSSF YRIGTVVAIA MDDLKFFDSP PIIDDRLSRF RDDFKTFVQR
VCAQARFYQD ELLLTCSEFV LTAPIELIAV HTMIGIVRSV LELGRSYLPA AIVAVTALER
WQKQCLNDLE DVISEVIPLL SAYLDQEALS DEESSLVKLS GKGMRNTSSN ETSDLAQLQR
RILLLLGKCG GKISLLMSEP PSLINADGSM GSISSPFFRL ELQLSELSIS LAMDPILSHL
GNLATHSSVR RVKASASEGY HALVCYLCGK TATYPHAAGK KSEFYDTWRG VFARIVRLAT
DPEKICRSLF EPLLFQLLRW MAANSDTFPF EYSSMLDELT RSLSDSETAV RTMSARCIAV
FLSLALENSK AQANADDIFE RVFSLCRHPG AVQRSGAAAS ISYFLRSFKE EDGQILTQFA
LPCLKNLLYA LRLCDNDVRN RIGGVDISRD VISKAVMKIK RGICRFPQLF LKGSTSARDV
DEDSVLQRTT LWLFQQTGAR EVLFRRLCQQ LFMSFSTLIS KSSAEWIQKY ASTHGSESVV
TVLVPMSSLA HTSITVQWME QLSASIESYV WCVEMLGDKA KDIFENSLTS RQESMKRKHF
ADVSAQEYSC QQTLSWAIAT FLKNGGPWED SLKGSHWTGA YLSVLTSLCC CVMSFMKTGN
VVLRNVADMD TQSFRGAVAE KLLQAILHLP DTQVHDANSL DGIEEFCSGV ITRSPDWAQQ
MQETVDSMLS NLQLCLANVN SSESFVEHSI TIGLLSFFGS KVLSAGIISF PVADKYVEMF
AMVASKAMEY GHGSPHDRLV AIAALKAAAA CGWRITDIFA NPADRQVYGP VYSDVIHFMP
TLAVWNRCAS ELVSQSLKND FVVNVLADIL CQVTSFKVYP SKSADWDVFT KTLVANVKQF
VSNLEAVKAD TQRVLSTLQV LRHFLELCQH CSESIVEALR MGPIPDIQDA IIKLLKQRGC
SYLVKAEVLR MLALLGPTSL LVSNEEQASK AMLDALVALV FDEFPIVSVD VARGSKEFDV
FYLLFSELLG VIERSNSIAY LKIIYPSLKE ADNHLFRTEI KQMLARFSIS LGSQTGHATS
GERIRHQLVE LLDVLLDPTL DIAIRKTLLE EVFTPLVECQ TGETLLQFYL MESLTKKSTI
ISLLATLVST AAEVSSGGSR IGVFVAFSLV EILYRLIDPE IIRTEINSAF LGHKNGKGRE
FTMLVCKCAS KVVTKTYGDV DDLVRLACCA AYNCLLTAVS RTQKQEKFFD QILFQPALWS
NILDLSREYE LHAETETFAT IPLSSLSAIS LEARLDTNAT TNAKSKRNES AALRFFTASS
LSMDTDSQTA STLTASLDVN QVGSTYENIE IELDTFNQHP CMIPLLRVLV QMKTDFGSSW
SEKAMPGWMK KIFDVIVDPS TGLNVRLFVA KVVLNVPNVF AMYSSPWLRA VMEALLDASA
AQKAPEFNYI LRDCCNLVLN SWKDVAVSSL SDTASRFVNE LVKICPELNN LIRNSNVLLI
TELIALWKDS ASVDAGVLIT YMINDDDDSK MKSAKQFAAL QIVSAMLTTG LESELLVEEG
GQTIEDGILL VMTSKTTSLY TLAAEVGGLY LQTAGHSEGE EFMCKVRNLI IGSYNEENFG
RFLALLRNAS MHQPEIIDSV MLQRLSFVLP KAVAVDAWAL LAADSLNNAA GNESVVKDIF
THAQSVLGRF VAHRHAGVQL STLGAISRLL DHLNLSELER LIANTSEGGI GTLKCYEGHD
LSEYRRLLFT VGKKLYEKDL SDQVKSRVRV SLLHGLCDSD DQRRKEAFEY WNTSAAIVNS
CSDRLLSIFG SLYSSEFDEK WILYATNLLV GMSKESSEFE RPLFTSALGS GEYAETPIDA
SWEAKTQSMA PLFSVEADLF SARPEFTQQS TSLTYTASQA DGSLGSTIQS QLFLSKPASI
GASYSQSFGE SDVVQQRPGR NRFFKRRAAA VNSAVKDPSS YDKKASKRFF QDQYALLKKK
EEAQKTRERK QRQGHVSMKR TYRVGEFPDI QITQQDIVDP IMALCETSIE TSSLVFGALF
SSIVASPQFE KSGITHELTE RLEETLTLSQ SSSVYVGCIV SAYFASIVRN PRLCEMLPVR
PKTVGEAGLS SGKYHISELT LEEQLLHEIQ GKTRDLNLAS NELVTNCWDL LHKLLSTMHK
RNLLIALSMT CSTTAESKLA LQAQLSGDLP LAIASYKKAE SILDSQMEIL DGDNSFATET
DATRCRWQRR NCLETLNNWD TLKNELTDAT QTDSDFLWKQ RPPYLEQGVG HYLRSCLGLV
EAKQTNSDLA SLRSFIEGAM RDSAKMELVQ SRFPVEMCLT YLSSSDKNQA RVCVETFYTN
FLKMWRQTSP MASTSRMQLL QSLSSMVEID EVLSRFGRDY SDIGKMGHQS VTAFMDAWRR
SPPSTGEEGM VLWSQHSMVQ NTVAGFMLNY ARDQGLYSDE IGLAVLGGKS NTMLQYANAA
ISCNILALAS KMLKNYRELC NTHQLPKLSV QMVEVFVSHV LKLVDRQEHQ SDKSGSNSSS
IKLITRYYET ATKMFDNVEI MNMMETAGAS DKVAMGYLEA KTFASAAGFY AVNDVDDNLK
EEYLSRSLDM FKVSCKRIDA VSRKEMEDGA SSAFLRCRLT FIEFLNDLFF KRKMEKLAKL
TDRKALTKLL AENVLGGMAA GDRECANYFP QLCDVIAPYP DIVAEFEQCV LTNVPLWTCL
QWSAQLMALL NGPIGKTIVA ILEKMAEKYP VALFYDFMVT CRSSLGKFKV DLHRLEVLLS
NTVMEKFVTA LRLIHHPELR LKEGLREIAK LIEDNRMSDA RQKVEHIWKD CFSPDHPLLG
TQIGRYNRDW SRKAKRDVEK IMGKDGSKMT AKTVNTAREW IMNHFGVTPG RYGITKDMKA
HLGDFAEWLE EFDHSSCILE LPGQYTSYWR PPDPSTHIRI LSFDSMLGVL ASKQLPKRLT
MHCSDEKDYT FLVKGGEDLR LDQRIEQLFG VMNQILEADP RCCDQRLSLT TYDVIPMTQE
IGLLEWVGGT TTLKAVIEAQ LQIDERCVDL KSNKRQKLEL FNTTAAKTYE SFLLKQRGAS
FSAKVVAPRS KDVVDQFAKV QAMIPADLLR RQLLGLGSNF EAFLLVRDQF LKSVAVFSAC
SYVLGIGDRH LDNFLLDLAS GRVIGIDFGV SFGSGASVLP VPELIPFRYT RQMDFVFQPY
DGANLLAQEM QAVFDALRSK RQVVESVMNV FLHEPLLDWQ QSTTTRQKAL FESKGDDQST
LQDSDVEMED VEEPRKTTSP AGGNETTAWL PDVKITIARR KLEGVSPALL LKEELAQNPH
LKPHLSKFHV LVDTANIGED GADEMVELSS LTQAQELLAM ATAPDLLGRT FQGWMPWL
//
