ID V9FGY1_PHYPR Unreviewed; 3490 AA.
AC V9FGY1;
DT 19-FEB-2014, integrated into UniProtKB/TrEMBL.
DT 19-FEB-2014, sequence version 1.
DT 27-MAR-2024, entry version 41.
DE SubName: Full=Uncharacterized protein {ECO:0000313|EMBL:ETI49677.1};
GN ORFNames=F443_06490 {ECO:0000313|EMBL:ETI49677.1};
OS Phytophthora parasitica P1569.
OC Eukaryota; Sar; Stramenopiles; Oomycota; Peronosporales; Peronosporaceae;
OC Phytophthora.
OX NCBI_TaxID=1317065 {ECO:0000313|EMBL:ETI49677.1, ECO:0000313|Proteomes:UP000018721};
RN [1] {ECO:0000313|EMBL:ETI49677.1, ECO:0000313|Proteomes:UP000018721}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=P1569 {ECO:0000313|EMBL:ETI49677.1,
RC ECO:0000313|Proteomes:UP000018721};
RG The Broad Institute Genomics Platform;
RA Russ C., Tyler B., Panabieres F., Shan W., Tripathy S., Grunwald N.,
RA Machado M., Johnson C.S., Arredondo F., Hong C., Coffey M., Young S.K.,
RA Zeng Q., Gargeya S., Fitzgerald M., Abouelleil A., Alvarado L.,
RA Chapman S.B., Gainer-Dewar J., Goldberg J., Griggs A., Gujja S., Hansen M.,
RA Howarth C., Imamovic A., Ireland A., Larimer J., McCowan C., Murphy C.,
RA Pearson M., Poon T.W., Priest M., Roberts A., Saif S., Shea T., Sykes S.,
RA Wortman J., Nusbaum C., Birren B.;
RT "The Genome Sequence of Phytophthora parasitica P1569.";
RL Submitted (NOV-2013) to the EMBL/GenBank/DDBJ databases.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:ETI49677.1}.
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DR EMBL; ANIZ01001092; ETI49677.1; -; Genomic_DNA.
DR EMBL; ANIZ01001092; ETI49678.1; -; Genomic_DNA.
DR EMBL; ANIZ01001092; ETI49679.1; -; Genomic_DNA.
DR EnsemblProtists; ETI49677; ETI49677; F443_06490.
DR EnsemblProtists; ETI49678; ETI49678; F443_06490.
DR EnsemblProtists; ETI49679; ETI49679; F443_06490.
DR OrthoDB; 8448at2759; -.
DR Proteomes; UP000018721; Unassembled WGS sequence.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0004677; F:DNA-dependent protein kinase activity; IEA:InterPro.
DR GO; GO:0006303; P:double-strand break repair via nonhomologous end joining; IEA:InterPro.
DR CDD; cd05172; PIKKc_DNA-PK; 1.
DR Gene3D; 1.25.10.10; Leucine-rich Repeat Variant; 1.
DR Gene3D; 1.10.1070.11; Phosphatidylinositol 3-/4-kinase, catalytic domain; 1.
DR InterPro; IPR011989; ARM-like.
DR InterPro; IPR016024; ARM-type_fold.
DR InterPro; IPR037706; DNA-PK_dom.
DR InterPro; IPR046804; DNA-PKcs_N.
DR InterPro; IPR046803; DNAPKcs_CC1-2.
DR InterPro; IPR012582; DNAPKcs_CC3.
DR InterPro; IPR045581; DNAPKcs_CC5.
DR InterPro; IPR003152; FATC_dom.
DR InterPro; IPR011009; Kinase-like_dom_sf.
DR InterPro; IPR000403; PI3/4_kinase_cat_dom.
DR InterPro; IPR036940; PI3/4_kinase_cat_sf.
DR PANTHER; PTHR11139; ATAXIA TELANGIECTASIA MUTATED ATM -RELATED; 1.
DR PANTHER; PTHR11139:SF68; DNA-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT; 1.
DR Pfam; PF20500; DNA-PKcs_N; 1.
DR Pfam; PF20502; DNAPKcs_CC1-2; 1.
DR Pfam; PF08163; DNAPKcs_CC3; 1.
DR Pfam; PF19704; DNAPKcs_CC5; 2.
DR Pfam; PF00454; PI3_PI4_kinase; 1.
DR SMART; SM01343; FATC; 1.
DR SMART; SM01344; NUC194; 1.
DR SMART; SM00146; PI3Kc; 1.
DR SUPFAM; SSF48371; ARM repeat; 2.
DR SUPFAM; SSF56112; Protein kinase-like (PK-like); 1.
DR PROSITE; PS51190; FATC; 1.
DR PROSITE; PS50290; PI3_4_KINASE_3; 1.
PE 4: Predicted;
KW DNA damage {ECO:0000256|ARBA:ARBA00022763};
KW DNA repair {ECO:0000256|ARBA:ARBA00023204};
KW Kinase {ECO:0000256|ARBA:ARBA00022527};
KW Phosphoprotein {ECO:0000256|ARBA:ARBA00022553};
KW Reference proteome {ECO:0000313|Proteomes:UP000018721};
KW Serine/threonine-protein kinase {ECO:0000256|ARBA:ARBA00022527};
KW Transferase {ECO:0000256|ARBA:ARBA00022527}.
FT DOMAIN 3055..3392
FT /note="PI3K/PI4K catalytic"
FT /evidence="ECO:0000259|PROSITE:PS50290"
FT DOMAIN 3458..3490
FT /note="FATC"
FT /evidence="ECO:0000259|PROSITE:PS51190"
FT REGION 3360..3398
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 3490 AA; 389557 MW; 64C69815BC0F5ECF CRC64;
MLGRCTEMAA EPTLVAMKTG SDDVEMKEPS DVGRSLQTII FDSTVKHVLG IIGQLNLSYQ
FDLQTTNNGK NATGYLVRCA ALRSFTCCLY DMSFYAQPQP TVPRDHSIML NMTEFVERVL
GQVLRPLLRP WIPLIMQRVM SSASKLPLVS SFYRIGTVVA IAMDDLKFFD SPPIIDDRLS
RFRDDFKTFV QRVCAQARFY QDELLLTCSE FVLTAPIELI AVHTMIGIVR SVLELGRSYL
PAAIVAVTAL ERWQKQCLND LEDVISEVIP LLSAYLDQEA LSDEESSLVK LSGKGMRNTS
SNETSDLAQL QRRILLLLGK CGGKISLLMS EPPSLINADG SMGSISSPFF RLELQLSELS
ISLAMDPILS HLGNLATHSS VRRVKASASE GYHALVCYLC GKTATYPHAA GKKSEFYDTW
RGVFARIVRL ATDPEKICRS LFEPLLFQLL RWMAANSDTF PFEYSSMLDE LTRSLSDSET
AVRTMSARCI AVFLSLALEN SKAQANADDI FERVFSLCRH PGAVQRSGAA ASISYFLRSF
KEEDGQILTQ FALPCLKNLL YALRLCDNDV RNRIGGVDIS RDVISKAVMK IKRGICRFPQ
LFLKGSTSAR DVDEDSVLQR TTLWLFQQTG AREVLFRRLC QQLFMSFSTL ISKSSAEWIQ
KYASTHGSES VVTVLVPMSS LAHTSITVQW MEQLSASIES YVWCVEMLGD KAKDIFENSL
TSRQESMKRK HFADVSAQEY SCQQTLSWAI ATFLKNGGPW EDSLKGSHWT GAYLSVLTSL
CCCVMSFMKT GNVVLRNVAD MDTQSFRGAV AEKLLQAILH LPDTQVHDAN SLDGIEEFCS
GVITRSPDWA QQMQETVDSM LSNLQLCLAN VNSSESFVEH SITIGLLSFF GSKVLSAGII
SFPVADKYVE MFAMVASKAM EYGHGSPHDR LVAIAALKAA AACGWRITDI FANPADRQVY
GPVYSDVIHF MPTLAVWNRC ASELVSQSLK NDFVVNVLAD ILCQVTSFKV YPSKSADWDV
FTKTLVANVK QFVSNLEAVK ADTQRVLSTL QVLRHFLELC QHCSESIVEA LRMGPIPDIQ
DAIIKLLKQR GCSYLVKAEV LRMLALLGPT SLLVSNEEQA SKAMLDALVA LVFDEFPIVS
VDVARGSKEF DVFYLLFSEL LGVIERSNSI AYLKIIYPSL KEADNHLFRT EIKQMLARFS
ISLGSQTGHA TSGERIRHQL VELLDVLLDP TLDIAIRKTL LEEVFTPLVE CQTGETLLQF
YLMESLTKKS TIISLLATLV STAAEVSSGG SRIGVFVAFS LVEILYRLID PEIIRTEINS
AFLGHKNGKG REFTMLVCKC ASKVVTKTYG DVDDLVRLAC CAAYNCLLTA VSRTQKQEKF
FDQILFQPAL WSNILDLSRE YELHAETETF ATIPLSSLSA ISLEARLDTN ATTNAKSKRN
ESAALRFFTA SSLSMDTDSQ TASTLTASLD VNQVGSTYEN IEIELDTFNQ HPCMIPLLRV
LVQMKTDFGS SWSEKAMPGW MKKIFDVIVD PSTGLNVRLF VAKVVLNVPN VFAMYSSPWL
RAVMEALLDA SAAQKAPEFN YILRDCCNLV LNSWKDVAVS SLSDTASRFV NELVKICPEL
NNLIRNSNVL LITELIALWK DSASVDAGVL ITYMINDDDD SKMKSAKQFA ALQIVSAMLT
TGLESELLVE EGGQTIEDGI LLVMTSKTTS LYTLAAEVGG LYLQTAGHSE GEEFMCKVRN
LIIGSYNEEN FGRFLALLRN ASMHQPEIID SVMLQRLSFV LPKAVAVDAW ALLAADSLNN
AAGNESVVKD IFTHAQSVLG RFVAHRHAGV QLSTLGAISR LLDHLNLSEL ERLIANTSEG
GIGTLKCYEG HDLSEYRRLL FTVGKKLYEK DLSDQVKSRV RVSLLHGLCD SDDQRRKEAF
EYWNTSAAIV NSCSDRLLSI FGSLYSSEFD EKWILYATNL LVGMSKESSE FERPLFTSAL
GSGEYAETPI DASWEAKTQS MAPLFSVEAD LFSARPEFTQ QSTSLTYTAS QADGSLGSTI
QSQLFLSKPA SIGASYSQSF GESDVVQQRP GRNRFFKRRA AAVNSAVKDP SSYDKKASKR
FFQDQYALLK KKEEAQKTRE RKQRQGHVSM KRTYRVGEFP DIQITQQDIV DPIMALCETS
IETSSLVFGA LFSSIVASPQ FEKSGITHEL TERLEETLTL SQSSSVYVGC IVSAYFASIV
RNPRLCEMLP VRPKTVGEAG LSSGKYHISE LTLEEQLLHE IQGKTRDLNL ASNELVTNCW
DLLHKLLSTM HKRNLLIALS MTCSTTAESK LALQAQLSGD LPLAIASYKK AESILDSQME
ILDGDNSFAT ETDATRCRWQ RRNCLETLNN WDTLKNELTD ATQTDSDFLW KQRPPYLEQG
VGHYLRSCLG LVEAKQTNSD LASLRSFIEG AMRDSAKMEL VQSRFPVEMC LTYLSSSDKN
QARVCVETFY TNFLKMWRQT SPMASTSRMQ LLQSLSSMVE IDEVLSRFGR DYSDIGKMGH
QSVTAFMDAW RRSPPSTGEE GMVLWSQHSM VQNTVAGFML NYARDQGLYS DEIGLAVLGG
KSNTMLQYAN AAISCNILAL ASKMLKNYRE LCNTHQLPKL SVQMVEVFVS HVLKLVDRQE
HQSDKSGSNS SSIKLITRYY ETATKMFDNV EIMNMMETAG ASDKVAMGYL EAKTFASAAG
FYAVNDVDDN LKEEYLSRSL DMFKVSCKRI DAVSRKEMED GASSAFLRCR LTFIEFLNDL
FFKRKMEKLA KLTDRKALTK LLAENVLGGM AAGDRECANY FPQLCDVIAP YPDIVAEFEQ
CVLTNVPLWT CLQWSAQLMA LLNGPIGKTI VAILEKMAEK YPVALFYDFM VTCRSSLGKF
KVDLHRLEVL LSNTVMEKFV TALRLIHHPE LRLKEGLREI AKLIEDNRMS DARQKVEHIW
KDCFSPDHPL LGTQIGRYNR DWSRKAKRDV EKIMGKDGSK MTAKTVNTAR EWIMNHFGVT
PGRYGITKDM KAHLGDFAEW LEEFDHSSCI LELPGQYTSY WRPPDPSTHI RILSFDSMLG
VLASKQLPKR LTMHCSDEKD YTFLVKGGED LRLDQRIEQL FGVMNQILEA DPRCCDQRLS
LTTYDVIPMT QEIGLLEWVG GTTTLKAVIE AQLQIDERCV DLKSNKRQKL ELFNTTAAKT
YESFLLKQRG ASFSAKVVAP RSKDVVDQFA KVQAMIPADL LRRQLLGLGS NFEAFLLVRD
QFLKSVAVFS ACSYVLGIGD RHLDNFLLDL ASGRVIGIDF GVSFGSGASV LPVPELIPFR
YTRQMDFVFQ PYDGANLLAQ EMQAVFDALR SKRQVVESVM NVFLHEPLLD WQQSTTTRQK
ALFESKGDDQ STLQDSDVEM EDVEEPRKTT SPAGGNETTA WLPDVKITIA RRKLEGVSPA
LLLKEELAQN PHLKPHLSKF HVLVDTANIG EDGADEMVEL SSLTQAQELL AMATAPDLLG
RTFQGWMPWL
//
