ID V9H5P2_9NEIS Unreviewed; 837 AA.
AC V9H5P2;
DT 19-FEB-2014, integrated into UniProtKB/TrEMBL.
DT 19-FEB-2014, sequence version 1.
DT 24-JAN-2024, entry version 49.
DE RecName: Full=DNA (cytosine-5-)-methyltransferase {ECO:0000256|ARBA:ARBA00011975};
DE EC=2.1.1.37 {ECO:0000256|ARBA:ARBA00011975};
GN ORFNames=HMPREF9021_01474 {ECO:0000313|EMBL:EFG30507.1};
OS Simonsiella muelleri ATCC 29453.
OC Bacteria; Pseudomonadota; Betaproteobacteria; Neisseriales; Neisseriaceae;
OC Simonsiella.
OX NCBI_TaxID=641147 {ECO:0000313|EMBL:EFG30507.1, ECO:0000313|Proteomes:UP000017813};
RN [1] {ECO:0000313|EMBL:EFG30507.1, ECO:0000313|Proteomes:UP000017813}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 29453 {ECO:0000313|EMBL:EFG30507.1,
RC ECO:0000313|Proteomes:UP000017813};
RG The Broad Institute Genome Sequencing Platform;
RA Ward D., Earl A., Feldgarden M., Gevers D., Young S., Zeng Q., Koehrsen M.,
RA Alvarado L., Berlin A.M., Borenstein D., Chapman S.B., Chen Z., Engels R.,
RA Freedman E., Gellesch M., Goldberg J., Griggs A., Gujja S., Heilman E.R.,
RA Heiman D.I., Hepburn T.A., Howarth C., Jen D., Larson L., Mehta T.,
RA Park D., Pearson M., Richards J., Roberts A., Saif S., Shea T.D.,
RA Shenoy N., Sisk P., Stolte C., Sykes S.N., Walk T., White J., Yandava C.,
RA Izard J., Baranova O.V., Blanton J.M., Tanner A.C., Dewhirst F., Haas B.,
RA Nusbaum C., Birren B.;
RL Submitted (MAR-2010) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|EMBL:EFG30507.1, ECO:0000313|Proteomes:UP000017813}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 29453 {ECO:0000313|EMBL:EFG30507.1,
RC ECO:0000313|Proteomes:UP000017813};
RG The Broad Institute Genome Sequencing Platform;
RG The Broad Institute Genome Sequencing Center for Infectious Disease;
RA Earl A., Ward D., Feldgarden M., Gevers D., Izard J., Baranova O.V.,
RA Blanton J.M., Tanner A.C., Dewhirst F., Young S.K., Zeng Q., Gargeya S.,
RA Fitzgerald M., Haas B., Abouelleil A., Alvarado L., Arachchi H.M.,
RA Berlin A., Brown A., Chapman S.B., Chen Z., Dunbar C., Freedman E.,
RA Gearin G., Goldberg J., Griggs A., Gujja S., Heiman D., Howarth C.,
RA Larson L., Lui A., MacDonald P.J.P., Montmayeur A., Murphy C., Neiman D.,
RA Pearson M., Priest M., Roberts A., Saif S., Shea T., Shenoy N., Sisk P.,
RA Stolte C., Sykes S., Wortman J., Nusbaum C., Birren B.;
RT "The Genome Sequence of Simonsiella muelleri ATCC 29453.";
RL Submitted (OCT-2011) to the EMBL/GenBank/DDBJ databases.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=a 2'-deoxycytidine in DNA + S-adenosyl-L-methionine = a 5-
CC methyl-2'-deoxycytidine in DNA + H(+) + S-adenosyl-L-homocysteine;
CC Xref=Rhea:RHEA:13681, Rhea:RHEA-COMP:11369, Rhea:RHEA-COMP:11370,
CC ChEBI:CHEBI:15378, ChEBI:CHEBI:57856, ChEBI:CHEBI:59789,
CC ChEBI:CHEBI:85452, ChEBI:CHEBI:85454; EC=2.1.1.37;
CC Evidence={ECO:0000256|ARBA:ARBA00000743};
CC -!- SIMILARITY: Belongs to the class I-like SAM-binding methyltransferase
CC superfamily. C5-methyltransferase family. {ECO:0000256|PROSITE-
CC ProRule:PRU01016}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:EFG30507.1}.
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DR EMBL; ADCY02000044; EFG30507.1; -; Genomic_DNA.
DR RefSeq; WP_002642436.1; NZ_JH815305.1.
DR AlphaFoldDB; V9H5P2; -.
DR STRING; 641147.HMPREF9021_01474; -.
DR KEGG; smur:BWP33_10945; -.
DR eggNOG; COG0270; Bacteria.
DR eggNOG; COG0827; Bacteria.
DR HOGENOM; CLU_006958_11_0_4; -.
DR OrthoDB; 9813719at2; -.
DR Proteomes; UP000017813; Unassembled WGS sequence.
DR GO; GO:0003886; F:DNA (cytosine-5-)-methyltransferase activity; IEA:UniProtKB-EC.
DR GO; GO:0003676; F:nucleic acid binding; IEA:InterPro.
DR GO; GO:0009307; P:DNA restriction-modification system; IEA:UniProtKB-KW.
DR CDD; cd02440; AdoMet_MTases; 1.
DR Gene3D; 3.90.120.10; DNA Methylase, subunit A, domain 2; 1.
DR Gene3D; 3.40.50.150; Vaccinia Virus protein VP39; 2.
DR InterPro; IPR018117; C5_DNA_meth_AS.
DR InterPro; IPR001525; C5_MeTfrase.
DR InterPro; IPR002052; DNA_methylase_N6_adenine_CS.
DR InterPro; IPR029063; SAM-dependent_MTases_sf.
DR NCBIfam; TIGR00675; dcm; 1.
DR PANTHER; PTHR10629; CYTOSINE-SPECIFIC METHYLTRANSFERASE; 1.
DR PANTHER; PTHR10629:SF52; DNA (CYTOSINE-5)-METHYLTRANSFERASE 1; 1.
DR Pfam; PF00145; DNA_methylase; 1.
DR PRINTS; PR00507; N12N6MTFRASE.
DR SUPFAM; SSF53335; S-adenosyl-L-methionine-dependent methyltransferases; 2.
DR PROSITE; PS00094; C5_MTASE_1; 1.
DR PROSITE; PS00092; N6_MTASE; 1.
DR PROSITE; PS51679; SAM_MT_C5; 1.
PE 3: Inferred from homology;
KW Methyltransferase {ECO:0000256|ARBA:ARBA00022603, ECO:0000256|PROSITE-
KW ProRule:PRU01016}; Reference proteome {ECO:0000313|Proteomes:UP000017813};
KW Restriction system {ECO:0000256|ARBA:ARBA00022747};
KW S-adenosyl-L-methionine {ECO:0000256|ARBA:ARBA00022691,
KW ECO:0000256|PROSITE-ProRule:PRU01016};
KW Transferase {ECO:0000256|ARBA:ARBA00022679, ECO:0000256|PROSITE-
KW ProRule:PRU01016}.
FT ACT_SITE 93
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU01016"
SQ SEQUENCE 837 AA; 96959 MW; 3F0A2DB6DF4CCBF2 CRC64;
MLNNQLTYIS LFSSAGVGCY GFKQAGFECI ATNELLPKRL NIQKLNNKCR YETGYIAGDI
QQAETKQAIY AEIEKWHKLG NDKVDVVIAT PPCQGMSVAN HKKNDDDLNR NSLIVQSVEM
IKQIQPRFFI FENVPLFWKT GCVNQQGDIM SIGAMISAEL GVNYTIYHQV INFKNYGAYS
SRTRTVVIGV EKKLAQTISP LELYPDYQEE TVLQNVIGSL KSLEWGEYDE QDFYHSFRIY
PEHMRAWIHD LKQGQSAFEQ TDPLKIPHQI KDGKRVVNAS KNGDKYTRQK WQAVAPCIHT
RNDQLASQNT VHPTDDRVFS IRELMKLMSI PDDFQWLSQS LVELNALDAD EKRKVSKKEE
MNIRQSIGEA VPTIIFKQIA EKIDFFFKQK GLPEKEITQL INELNLSDTV HLIQFIENYR
HEIHWTSLSS IIELANAKRH NHSAFFTNSF IIDEIVRHLP KFNKDEITIV EPSVGSGNFL
PLLFKYYADI PKVNLIVVDI DSNMIEILKV MYAQPYLPKN ISITFICQNF MQVQLSQPID
LIVGNPPFTK LGKKEISEYI DNNYNKKATN LAEFFLEKAV HMADYVSFVM PKNLLNTPEY
VLTREFLYPF SILNILDIGE KGFKGVLVET INILISKIDK AHKVWVQSLT ESIILLQEKE
YIFDKSLPYW VIYRNNFFDN VAKKLTFGIF NVFRDRQITN SNSSFERKNA DDIRIIKSRN
INKLGTELIN IEQYDAFISL NDAQSMAVYQ YLQRDDVYMT PNMTYNPRLM KKQRGYIVNG
SVALLIPKEK VELSPQQMLY ISSDEFRQFY RIARNYQTRS LNIDSTSVYW FGLYNGD
//
