ID   V9K8S3_CALMI            Unreviewed;      1311 AA.
AC   V9K8S3;
DT   19-MAR-2014, integrated into UniProtKB/TrEMBL.
DT   19-MAR-2014, sequence version 1.
DT   24-JAN-2024, entry version 30.
DE   SubName: Full=Astrotactin-2 {ECO:0000313|EMBL:AFO94510.1};
DE   Flags: Fragment;
OS   Callorhinchus milii (Ghost shark).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Chondrichthyes;
OC   Holocephali; Chimaeriformes; Callorhinchidae; Callorhinchus.
OX   NCBI_TaxID=7868 {ECO:0000313|EMBL:AFO94510.1};
RN   [1] {ECO:0000313|EMBL:AFO94510.1}
RP   NUCLEOTIDE SEQUENCE.
RC   TISSUE=Brain {ECO:0000313|EMBL:AFO94510.1};
RX   PubMed=24402279; DOI=10.1038/nature12826;
RG   International Elephant Shark Genome Sequencing Consortium;
RA   Venkatesh B., Lee A.P., Ravi V., Maurya A.K., Lian M.M., Swann J.B.,
RA   Ohta Y., Flajnik M.F., Sutoh Y., Kasahara M., Hoon S., Gangu V., Roy S.W.,
RA   Irimia M., Korzh V., Kondrychyn I., Lim Z.W., Tay B.H., Tohari S.,
RA   Kong K.W., Ho S., Lorente-Galdos B., Quilez J., Marques-Bonet T.,
RA   Raney B.J., Ingham P.W., Tay A., Hillier L.W., Minx P., Boehm T.,
RA   Wilson R.K., Brenner S., Warren W.C.;
RT   "Elephant shark genome provides unique insights into gnathostome
RT   evolution.";
RL   Nature 505:174-179(2014).
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DR   EMBL; JW861993; AFO94510.1; -; mRNA.
DR   GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR   GO; GO:0001764; P:neuron migration; IEA:InterPro.
DR   CDD; cd00063; FN3; 1.
DR   Gene3D; 2.60.40.10; Immunoglobulins; 1.
DR   Gene3D; 2.10.25.10; Laminin; 1.
DR   InterPro; IPR040685; Annexin-like.
DR   InterPro; IPR045574; ASTN1_2_Fn3.
DR   InterPro; IPR045575; ASTN_1_2_N.
DR   InterPro; IPR040510; ASTN_2_hairpin.
DR   InterPro; IPR026995; Astrotactin.
DR   InterPro; IPR000742; EGF-like_dom.
DR   InterPro; IPR003961; FN3_dom.
DR   InterPro; IPR036116; FN3_sf.
DR   InterPro; IPR013783; Ig-like_fold.
DR   InterPro; IPR020864; MACPF.
DR   PANTHER; PTHR16592; -; 1.
DR   PANTHER; PTHR16592:SF2; ASTROTACTIN-2; 1.
DR   Pfam; PF18411; Annexin_2; 1.
DR   Pfam; PF19743; ASTN1_2_fn3; 1.
DR   Pfam; PF19441; ASTN_1_2_N; 1.
DR   Pfam; PF18577; ASTN_2_hairpin; 1.
DR   Pfam; PF01823; MACPF; 1.
DR   SMART; SM00181; EGF; 3.
DR   SMART; SM00457; MACPF; 1.
DR   SUPFAM; SSF49265; Fibronectin type III; 1.
PE   2: Evidence at transcript level;
KW   Membrane {ECO:0000256|SAM:Phobius};
KW   Transmembrane {ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM        182..206
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   DOMAIN          485..522
FT                   /note="EGF-like"
FT                   /evidence="ECO:0000259|SMART:SM00181"
FT   DOMAIN          626..667
FT                   /note="EGF-like"
FT                   /evidence="ECO:0000259|SMART:SM00181"
FT   DOMAIN          674..723
FT                   /note="EGF-like"
FT                   /evidence="ECO:0000259|SMART:SM00181"
FT   DOMAIN          823..1007
FT                   /note="MACPF"
FT                   /evidence="ECO:0000259|SMART:SM00457"
FT   REGION          1..32
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          338..405
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        1..30
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        338..352
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        378..393
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   NON_TER         1
FT                   /evidence="ECO:0000313|EMBL:AFO94510.1"
SQ   SEQUENCE   1311 AA;  146815 MW;  F739E3EA40E700E2 CRC64;
     GGEGQGERDR GRGRGAERDR ETEGQRGRGA EAEGEGGMAV AVLLVELLLV VVVVPGVGAE
     VSRDGGCRVK TVSVSTLPVL RENDISFPGA LAAESKLFLF VKNDLPGEIL VIDDLENTEL
     PYFTLEMSGT VADISLIHWK QQWLENGTLY FHVSMSNAEH LSQITPPTMR EPSEIVDEQM
     HVLHVSVMGG LIALLLLILV FTMALYARRR WCKRRRVPQK SASTEATHEI HYIPSVLLGP
     QARDSFRNSR IQAHNSVVGM PIRETPILDD YDYDDEDNQL RPEACKREDD FGSQVTRTLE
     SLGRAEEEKP NLAAADVTHE TVESLMQKFK ESFRTNTPIE ISHLQQAPRS TATGRKKGRR
     NKSRGVMRGE DDSGTEADDE THLTFYSEQH RSRRKSKGSP RSPVNKTTLT LITVSSCVLA
     VVYGAHLTCP LVVKVTLHVP EHFIADGSSF VVSEGSFLDV SDWLNPARLS LFYQINSSSP
     WMRDLCGQRT LEPCEHLCDE DTGECGCHAG YSPDRVHKHL CVRSEWGQNE GPWPYTTLER
     GYDLVTGEQA PEKIFRSTYS LGQGLWLPVS KSFVVPPVEL SISPLASCKT DVLVTEDTGE
     VREEAMRSTY FETPDDLLSS FGPVRDCSRD NGGCTRNYRC VSDRKIDSTG CMCPEGLRPM
     RDVSGCFDYT KGVDCSDGFN GGCEQLCLQQ TVPLPKDHSS SNILMFCGCV EEYKLAADGK
     SCLLLSEICE GVKCQKLDAK LNDTLFVEML HGYNNKSQQV NQGQVIQMSF RENNFMKDFP
     QLADGLVVIA LPVEEQCRGV LSEPLPNLQF LTGDAKYSEA TGYPMVQEWR VRSNLYKVKI
     SATTLSAGFA NVQKVLNGES SREELIAIIQ QYGSHYITEA LYGSELTCKI HFPSKKVQQQ
     LWLQYQKETT ELGNKKELKS IPFISYLSGL LGAQMLSDEQ PITGVEIECE EKGQCPSTCH
     LCHRQGKDQV SPSPVLLEIT HIEPLYYLIE DNMTKEAFKT ALMSSYWCLG KGDVIDDWCR
     CDLTAFDEDG LPSCCPLPQP RLRLSTSVEP SSTMIGLEWQ DAQPAIGTKI ADYIIHYKKL
     DDFVDPDLYA GESLSFADDL LSGLGSSCVV VGKNYGDSSE ITVYSLIFKC LEPDSFYRFT
     LYALDSRGRR SEPSRVTMRT SCPLIDDTKA EEIADRIYNL FNGYTSGKEQ QTAYNMLMEI
     SSPMVYRVRH HYNSHYEKFG DFVWRTEDEL GPRKAHLILK RLDDVSHRCS ALLQSVYIQG
     HIDSVTYFVC RMEGSRPSGM VWYSTLHDAK VTCDEKLMTV SRNIYGDTKL R
//