ID   V9KR89_CALMI            Unreviewed;       563 AA.
AC   V9KR89;
DT   19-MAR-2014, integrated into UniProtKB/TrEMBL.
DT   19-MAR-2014, sequence version 1.
DT   22-FEB-2023, entry version 32.
DE   SubName: Full=Synemin {ECO:0000313|EMBL:AFP01281.1};
DE   Flags: Fragment;
OS   Callorhinchus milii (Ghost shark).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Chondrichthyes;
OC   Holocephali; Chimaeriformes; Callorhinchidae; Callorhinchus.
OX   NCBI_TaxID=7868 {ECO:0000313|EMBL:AFP01281.1};
RN   [1] {ECO:0000313|EMBL:AFP01281.1}
RP   NUCLEOTIDE SEQUENCE.
RC   TISSUE=Brain {ECO:0000313|EMBL:AFP01281.1};
RX   PubMed=24402279; DOI=10.1038/nature12826;
RG   International Elephant Shark Genome Sequencing Consortium;
RA   Venkatesh B., Lee A.P., Ravi V., Maurya A.K., Lian M.M., Swann J.B.,
RA   Ohta Y., Flajnik M.F., Sutoh Y., Kasahara M., Hoon S., Gangu V., Roy S.W.,
RA   Irimia M., Korzh V., Kondrychyn I., Lim Z.W., Tay B.H., Tohari S.,
RA   Kong K.W., Ho S., Lorente-Galdos B., Quilez J., Marques-Bonet T.,
RA   Raney B.J., Ingham P.W., Tay A., Hillier L.W., Minx P., Boehm T.,
RA   Wilson R.K., Brenner S., Warren W.C.;
RT   "Elephant shark genome provides unique insights into gnathostome
RT   evolution.";
RL   Nature 505:174-179(2014).
CC   -!- SIMILARITY: Belongs to the intermediate filament family.
CC       {ECO:0000256|RuleBase:RU000685}.
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DR   EMBL; JW868763; AFP01281.1; -; mRNA.
DR   AlphaFoldDB; V9KR89; -.
DR   GO; GO:0005882; C:intermediate filament; IEA:UniProtKB-KW.
DR   GO; GO:0005200; F:structural constituent of cytoskeleton; IEA:InterPro.
DR   GO; GO:0008307; F:structural constituent of muscle; IEA:InterPro.
DR   GO; GO:0045104; P:intermediate filament cytoskeleton organization; IEA:InterPro.
DR   Gene3D; 1.20.5.170; -; 1.
DR   InterPro; IPR018039; IF_conserved.
DR   InterPro; IPR039008; IF_rod_dom.
DR   InterPro; IPR030634; SYNM.
DR   PANTHER; PTHR47136; SYNEMIN; 1.
DR   PANTHER; PTHR47136:SF1; SYNEMIN; 1.
DR   Pfam; PF00038; Filament; 1.
DR   SUPFAM; SSF64593; Intermediate filament protein, coiled coil region; 1.
DR   PROSITE; PS00226; IF_ROD_1; 1.
PE   2: Evidence at transcript level;
KW   Coiled coil {ECO:0000256|ARBA:ARBA00023054, ECO:0000256|SAM:Coils};
KW   Intermediate filament {ECO:0000256|ARBA:ARBA00022754,
KW   ECO:0000256|RuleBase:RU000685}.
FT   DOMAIN          28..161
FT                   /note="IF rod"
FT                   /evidence="ECO:0000259|Pfam:PF00038"
FT   REGION          298..378
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COILED          61..134
FT                   /evidence="ECO:0000256|SAM:Coils"
FT   COMPBIAS        314..348
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   NON_TER         1
FT                   /evidence="ECO:0000313|EMBL:AFP01281.1"
FT   NON_TER         563
FT                   /evidence="ECO:0000313|EMBL:AFP01281.1"
SQ   SEQUENCE   563 AA;  64744 MW;  89347447BF8E3594 CRC64;
     TEEIRRAPQT IVAQCCNVAL VEQGVENYAA LFSEMWGETF EMYKSKIEEL EFIVQQGRGR
     SEDLEKEKIL LIREIEALKK ELRDQNDLQK RLEDDFLIVQ EKQDMDVGEY QRAIELLNDE
     KQHLESIIDQ NLKEQQQLMQ MKMGLSLEVA TYRALLEAEK NQQLETQDHL QKFRRGMDTT
     SHTFDVRPTI EWRGEKKWMP IRDIPMNVRG DVMNIRKRVI PNSNPSATKT TKSLFFNADL
     PNVDKKLSSK VHKDMFASAV TRNAYRGSTM ISPTYYDRYS TRKDHQAQHK VFPAKIERKS
     EVRVDKPGMQ WPEYHTPVTT SQSTLEGKGN ASNDANQISK SNEPTPSAPL NEMRGHDLNR
     KSAEPSKDEN YATQSTKDTS AFRHALREED FKTGLDDVEK LTGPRKIVCS AENGAKVEIT
     SEYLKTDGTD KKEIMSKEES NDDQIIIIGK EGSPRDNIKI GDKIIKPTDL EKMNFEPETN
     VTYVEKEEIL DDGTTKREIT IQSTTEKVMD DSYEYSLEEL LNEKEQSPEL QLKEALEHLT
     GTPTENVLEG LFKLGFKGRE SLE
//