ID   V9P8N6_9HEPC            Unreviewed;       192 AA.
AC   V9P8N6;
DT   19-MAR-2014, integrated into UniProtKB/TrEMBL.
DT   19-MAR-2014, sequence version 1.
DT   27-MAR-2024, entry version 27.
DE   SubName: Full=NS3 protease {ECO:0000313|EMBL:AGW00651.1};
DE   Flags: Fragment;
OS   Hepacivirus hominis.
OC   Viruses; Riboviria; Orthornavirae; Kitrinoviricota; Flasuviricetes;
OC   Amarillovirales; Flaviviridae; Hepacivirus.
OX   NCBI_TaxID=3052230 {ECO:0000313|EMBL:AGW00651.1};
RN   [1] {ECO:0000313|EMBL:AGW00651.1}
RP   NUCLEOTIDE SEQUENCE.
RC   STRAIN=7206373_2007_5_cl {ECO:0000313|EMBL:AGW00651.1};
RA   Colson P., Tamalet C., Baume J., Tourres C.;
RT   "Recurrence of HCV infection after 18 months of sustained virological
RT   response in an HIV-infected.";
RL   Submitted (NOV-2012) to the EMBL/GenBank/DDBJ databases.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=ATP + H2O = ADP + H(+) + phosphate; Xref=Rhea:RHEA:13065,
CC         ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616,
CC         ChEBI:CHEBI:43474, ChEBI:CHEBI:456216; EC=3.6.4.13;
CC         Evidence={ECO:0000256|ARBA:ARBA00001556};
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DR   EMBL; KC211892; AGW00651.1; -; Genomic_RNA.
DR   GO; GO:0033644; C:host cell membrane; IEA:UniProtKB-KW.
DR   GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR   GO; GO:0044423; C:virion component; IEA:UniProtKB-KW.
DR   GO; GO:0008236; F:serine-type peptidase activity; IEA:InterPro.
DR   GO; GO:0006508; P:proteolysis; IEA:UniProtKB-KW.
DR   GO; GO:0019087; P:transformation of host cell by virus; IEA:InterPro.
DR   GO; GO:0046718; P:viral entry into host cell; IEA:UniProtKB-KW.
DR   GO; GO:0019062; P:virion attachment to host cell; IEA:UniProtKB-KW.
DR   Gene3D; 2.40.10.120; -; 1.
DR   InterPro; IPR004109; HepC_NS3_protease.
DR   InterPro; IPR009003; Peptidase_S1_PA.
DR   Pfam; PF02907; Peptidase_S29; 1.
DR   SUPFAM; SSF50494; Trypsin-like serine proteases; 1.
DR   PROSITE; PS51822; HV_PV_NS3_PRO; 1.
PE   4: Predicted;
KW   Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW   Host membrane {ECO:0000256|ARBA:ARBA00022870};
KW   Host-virus interaction {ECO:0000256|ARBA:ARBA00022581};
KW   Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW   Membrane {ECO:0000256|ARBA:ARBA00023136};
KW   Protease {ECO:0000313|EMBL:AGW00651.1};
KW   Transmembrane {ECO:0000256|ARBA:ARBA00022692};
KW   Transmembrane helix {ECO:0000256|ARBA:ARBA00022989};
KW   Viral attachment to host cell {ECO:0000256|ARBA:ARBA00022804};
KW   Virion {ECO:0000256|ARBA:ARBA00022844};
KW   Virus entry into host cell {ECO:0000256|ARBA:ARBA00023296}.
FT   DOMAIN          1..182
FT                   /note="Peptidase S29"
FT                   /evidence="ECO:0000259|PROSITE:PS51822"
FT   NON_TER         1
FT                   /evidence="ECO:0000313|EMBL:AGW00651.1"
FT   NON_TER         192
FT                   /evidence="ECO:0000313|EMBL:AGW00651.1"
SQ   SEQUENCE   192 AA;  20224 MW;  75187A10521D7F6C CRC64;
     APITAYAQQT RGLLGCIVTS LTGRDKNQVE GEIQIVSTAT QTFLATCING VCWTVYHGAG
     TRTIASSKGP VIQMYTNVDQ DLVGWPAPQG ARSLTPCTCG SSDLYLVTRQ ADVIPVRRRG
     DSRGSLLSPR PISYLKGSSG GPLLCPAGHA VGVFRAAVCT RGVAKAVDFI PVENLETTMR
     SPVFTDNSSP PA
//