ID V9PCC4_MOUSE Unreviewed; 748 AA.
AC V9PCC4;
DT 19-MAR-2014, integrated into UniProtKB/TrEMBL.
DT 19-MAR-2014, sequence version 1.
DT 27-MAR-2024, entry version 51.
DE RecName: Full=Toll-like receptor 4 {ECO:0000256|ARBA:ARBA00040109};
DE Flags: Fragment;
GN Name=Tlr4 {ECO:0000313|EMBL:AGY29704.1};
OS Mus musculus domesticus (western European house mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10092 {ECO:0000313|EMBL:AGY29704.1};
RN [1] {ECO:0000313|EMBL:AGY29704.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=R307 {ECO:0000313|EMBL:AGY29704.1}, SK1773
RC {ECO:0000313|EMBL:AGY29712.1}, SK811 {ECO:0000313|EMBL:AGY29714.1},
RC and SU5229 {ECO:0000313|EMBL:AGY29710.1};
RA Fornuskova A.;
RT "Origin of polymorphism of innate immunity gene, toll-like receptor 4 in
RT the two subspecies of the wild house mouse, Mus musculus.";
RL Submitted (SEP-2013) to the EMBL/GenBank/DDBJ databases.
CC -!- SUBCELLULAR LOCATION: Cell projection, ruffle
CC {ECO:0000256|ARBA:ARBA00004466}. Early endosome
CC {ECO:0000256|ARBA:ARBA00004412}. Endosome
CC {ECO:0000256|ARBA:ARBA00004177}. Membrane
CC {ECO:0000256|ARBA:ARBA00004479}; Single-pass type I membrane protein
CC {ECO:0000256|ARBA:ARBA00004479}.
CC -!- SIMILARITY: Belongs to the Toll-like receptor family.
CC {ECO:0000256|ARBA:ARBA00009634}.
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DR EMBL; KF696915; AGY29704.1; -; Genomic_DNA.
DR EMBL; KF696921; AGY29710.1; -; Genomic_DNA.
DR EMBL; KF696923; AGY29712.1; -; Genomic_DNA.
DR EMBL; KF696925; AGY29714.1; -; Genomic_DNA.
DR AlphaFoldDB; V9PCC4; -.
DR GO; GO:0005769; C:early endosome; IEA:UniProtKB-SubCell.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0001726; C:ruffle; IEA:UniProtKB-SubCell.
DR GO; GO:0004888; F:transmembrane signaling receptor activity; IEA:InterPro.
DR GO; GO:0006954; P:inflammatory response; IEA:UniProtKB-KW.
DR GO; GO:0045087; P:innate immune response; IEA:UniProtKB-KW.
DR GO; GO:0001819; P:positive regulation of cytokine production; IEA:UniProt.
DR GO; GO:0032680; P:regulation of tumor necrosis factor production; IEA:UniProt.
DR GO; GO:0002224; P:toll-like receptor signaling pathway; IEA:InterPro.
DR Gene3D; 3.80.10.10; Ribonuclease Inhibitor; 1.
DR Gene3D; 3.40.50.10140; Toll/interleukin-1 receptor homology (TIR) domain; 1.
DR InterPro; IPR000483; Cys-rich_flank_reg_C.
DR InterPro; IPR001611; Leu-rich_rpt.
DR InterPro; IPR003591; Leu-rich_rpt_typical-subtyp.
DR InterPro; IPR032675; LRR_dom_sf.
DR InterPro; IPR000157; TIR_dom.
DR InterPro; IPR017241; Toll-like_receptor.
DR InterPro; IPR035897; Toll_tir_struct_dom_sf.
DR PANTHER; PTHR24365; TOLL-LIKE RECEPTOR; 1.
DR PANTHER; PTHR24365:SF521; TOLL-LIKE RECEPTOR 4; 1.
DR Pfam; PF13855; LRR_8; 2.
DR Pfam; PF01582; TIR; 1.
DR PIRSF; PIRSF037595; Toll-like_receptor; 5.
DR SMART; SM00369; LRR_TYP; 7.
DR SMART; SM00082; LRRCT; 1.
DR SMART; SM00255; TIR; 1.
DR SUPFAM; SSF52058; L domain-like; 2.
DR SUPFAM; SSF52200; Toll/Interleukin receptor TIR domain; 1.
DR PROSITE; PS50104; TIR; 1.
PE 3: Inferred from homology;
KW Cell projection {ECO:0000256|ARBA:ARBA00023273};
KW Endosome {ECO:0000256|ARBA:ARBA00022753};
KW Immunity {ECO:0000256|ARBA:ARBA00022859};
KW Inflammatory response {ECO:0000256|ARBA:ARBA00023198};
KW Innate immunity {ECO:0000256|ARBA:ARBA00022588};
KW Leucine-rich repeat {ECO:0000256|ARBA:ARBA00022614};
KW Membrane {ECO:0000256|SAM:Phobius};
KW Receptor {ECO:0000256|ARBA:ARBA00023170, ECO:0000313|EMBL:AGY29704.1};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Signal {ECO:0000256|ARBA:ARBA00022729};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT TRANSMEM 544..567
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 583..726
FT /note="TIR"
FT /evidence="ECO:0000259|PROSITE:PS50104"
FT NON_TER 1
FT /evidence="ECO:0000313|EMBL:AGY29704.1"
FT NON_TER 748
FT /evidence="ECO:0000313|EMBL:AGY29704.1"
SQ SEQUENCE 748 AA; 85587 MW; 7801D310053BD302 CRC64;
EIETIEDKAW HGLHHLSNLI LTGNPIQSFS PGSFSGLTSL ENLVAVETKL ASLESFPIGQ
LITLKKLNVA HNFIHSCKLP AYFSNLTNLV HVDLSYNYIQ TITVNDLQFL RENPQVNLSL
DISLNPIDFI QDQAFQGIKL HELTLRGNFN SSNIMKTCLQ NLAGLHVHRL ILGEFKDERN
LEIFEPSIME GLCDVTIDEF RLTYTNDFSD DIVKFHCLAN VSAMSLAGVS IKYLEDVPKH
FKWQSLSIIR CQLKQFPTLD LPFLKSLTLT MNKGSISFKK VALPSLSYLD LSRNALSFSG
CCSYSDLGTN SLRHLDLSFN GAIIMSANFM GLEELQHLDF QHSTLKRVTE FSAFLSLEKL
LYLDISYTNT KIDFDGIFLG LTSLNTLKMA GNSFKDNTLS NVFANTTNLT FLDLSKCQLE
QISWGVFDTL HRLQLLNMSH NNLLFLDSSH YNQLYSLSTL DCSFNRIETS KGILQHFPKS
LAFFNLTNNS VACICEHQKF LQWVKDQKQF LVNVEQMTCA TPVEMNTSLV LDFNNSTCYM
YKTIISVSVV SVIVVSTVAF LIYHFYFHLI LIAGCKKYSR GESIYDAFVI YSSQNEDWVR
NELVKNLEEG VPRFHLCLHY RDFIPGVAIA ANIIQEGFHK SRKVIVVVSR HFIQSRWCIF
EYEIAQTWQF LSSRSGIIFI VLEKVEKSLL RQQVELYRLL SRNTYLEWED NPLGRHIFWR
RLKNALLDGK ASNPEQTAEE EQETATWT
//
