ID   V9VN96_9RHOB            Unreviewed;       408 AA.
AC   V9VN96;
DT   19-MAR-2014, integrated into UniProtKB/TrEMBL.
DT   19-MAR-2014, sequence version 1.
DT   24-JAN-2024, entry version 27.
DE   SubName: Full=Cobalamin synthesis protein CobW {ECO:0000313|EMBL:AHD00121.1};
GN   ORFNames=METH_04765 {ECO:0000313|EMBL:AHD00121.1};
OS   Leisingera methylohalidivorans DSM 14336.
OC   Bacteria; Pseudomonadota; Alphaproteobacteria; Rhodobacterales;
OC   Roseobacteraceae; Leisingera.
OX   NCBI_TaxID=999552 {ECO:0000313|EMBL:AHD00121.1, ECO:0000313|Proteomes:UP000018780};
RN   [1] {ECO:0000313|EMBL:AHD00121.1, ECO:0000313|Proteomes:UP000018780}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=DSM 14336 {ECO:0000313|EMBL:AHD00121.1,
RC   ECO:0000313|Proteomes:UP000018780};
RG   DOE Joint Genome Institute;
RA   Klenk H.-P., Huntemann M., Han J., Chen A., Kyrpides N., Mavromatis K.,
RA   Markowitz V., Palaniappan K., Ivanova N., Schaumberg A., Pati A.,
RA   Liolios K., Nordberg H.P., Cantor M.N., Hua S.X., Woyke T.;
RL   Submitted (SEP-2013) to the EMBL/GenBank/DDBJ databases.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=GTP + H2O = GDP + H(+) + phosphate; Xref=Rhea:RHEA:19669,
CC         ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:37565,
CC         ChEBI:CHEBI:43474, ChEBI:CHEBI:58189;
CC         Evidence={ECO:0000256|ARBA:ARBA00001702};
CC       PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:19670;
CC         Evidence={ECO:0000256|ARBA:ARBA00001702};
CC   -!- SIMILARITY: Belongs to the SIMIBI class G3E GTPase family. ZNG1
CC       subfamily. {ECO:0000256|ARBA:ARBA00034320}.
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DR   EMBL; CP006773; AHD00121.1; -; Genomic_DNA.
DR   RefSeq; WP_024089244.1; NC_023135.1.
DR   AlphaFoldDB; V9VN96; -.
DR   STRING; 999552.METH_04765; -.
DR   KEGG; lmd:METH_04765; -.
DR   PATRIC; fig|999552.6.peg.950; -.
DR   HOGENOM; CLU_017452_2_0_5; -.
DR   OrthoDB; 9808822at2; -.
DR   Proteomes; UP000018780; Chromosome.
DR   GO; GO:0016787; F:hydrolase activity; IEA:UniProtKB-KW.
DR   CDD; cd03112; CobW-like; 1.
DR   Gene3D; 3.30.1220.10; CobW-like, C-terminal domain; 1.
DR   Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR   InterPro; IPR036627; CobW-likC_sf.
DR   InterPro; IPR011629; CobW-like_C.
DR   InterPro; IPR003495; CobW/HypB/UreG_dom.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   PANTHER; PTHR43603; COBW DOMAIN-CONTAINING PROTEIN DDB_G0274527; 1.
DR   PANTHER; PTHR43603:SF1; COBW DOMAIN-CONTAINING PROTEIN DDB_G0274527; 1.
DR   Pfam; PF02492; cobW; 1.
DR   Pfam; PF07683; CobW_C; 1.
DR   SMART; SM00833; CobW_C; 1.
DR   SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
PE   3: Inferred from homology;
KW   Hydrolase {ECO:0000256|ARBA:ARBA00022801}.
FT   DOMAIN          266..381
FT                   /note="CobW C-terminal"
FT                   /evidence="ECO:0000259|SMART:SM00833"
SQ   SEQUENCE   408 AA;  45113 MW;  6B24017E2082DC91 CRC64;
     MNTPAINTDT RLPVTVLSGF LGAGKTTLLN EVLQNRDGRR VAVIVNDMSE VNIDAGIIRD
     GDANLSHTEE TLVEMTNGCI CCTLRDDLLK EVSRLAAEGR FDYLLIESTG ISEPLPVAAT
     FDFRDEDGVS LSDVARLDTM VTVVDTVNLL KDYASHDFLR DRGEVMGEND DRTLVNLLVD
     QIEFADVVIL NKANDAGPAN VEAARMIVVA LNPDAQIIEA DYGKVPHGRI FDTRLFDFEK
     AHENPLWAKE LYGFSDHIPE TEEYGISSFV YCARRPFAPQ KVSDVLSGPL PGVIRAKGHF
     WIATRPDWVA EFSLAGALSS VKPMGIWWAT VPEDRRPASP QATEYLEHHW QEPFGDRRQE
     LVFIGSGMDK AAITAALDAA LVEDAHAFTP DAWASLPDPF PHWRRAPV
//