ID VTM2L_HUMAN Reviewed; 204 AA.
AC Q96N03; E1P5V7; Q5JWZ4; Q5JWZ5; Q8ND45; Q9BR37;
DT 13-DEC-2002, integrated into UniProtKB/Swiss-Prot.
DT 01-DEC-2001, sequence version 1.
DT 24-JAN-2024, entry version 167.
DE RecName: Full=V-set and transmembrane domain-containing protein 2-like protein;
DE Flags: Precursor;
GN Name=VSTM2L; Synonyms=C20orf102;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
RX PubMed=14702039; DOI=10.1038/ng1285;
RA Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H.,
RA Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M.,
RA Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K.,
RA Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T.,
RA Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M.,
RA Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S.,
RA Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H.,
RA Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K.,
RA Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N.,
RA Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y.,
RA Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K.,
RA Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T.,
RA Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T.,
RA Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y.,
RA Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H.,
RA Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y.,
RA Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H.,
RA Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O.,
RA Isogai T., Sugano S.;
RT "Complete sequencing and characterization of 21,243 full-length human
RT cDNAs.";
RL Nat. Genet. 36:40-45(2004).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
RC TISSUE=Brain;
RX PubMed=17974005; DOI=10.1186/1471-2164-8-399;
RA Bechtel S., Rosenfelder H., Duda A., Schmidt C.P., Ernst U.,
RA Wellenreuther R., Mehrle A., Schuster C., Bahr A., Bloecker H., Heubner D.,
RA Hoerlein A., Michel G., Wedler H., Koehrer K., Ottenwaelder B., Poustka A.,
RA Wiemann S., Schupp I.;
RT "The full-ORF clone resource of the German cDNA consortium.";
RL BMC Genomics 8:399-399(2007).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=11780052; DOI=10.1038/414865a;
RA Deloukas P., Matthews L.H., Ashurst J.L., Burton J., Gilbert J.G.R.,
RA Jones M., Stavrides G., Almeida J.P., Babbage A.K., Bagguley C.L.,
RA Bailey J., Barlow K.F., Bates K.N., Beard L.M., Beare D.M., Beasley O.P.,
RA Bird C.P., Blakey S.E., Bridgeman A.M., Brown A.J., Buck D., Burrill W.D.,
RA Butler A.P., Carder C., Carter N.P., Chapman J.C., Clamp M., Clark G.,
RA Clark L.N., Clark S.Y., Clee C.M., Clegg S., Cobley V.E., Collier R.E.,
RA Connor R.E., Corby N.R., Coulson A., Coville G.J., Deadman R., Dhami P.D.,
RA Dunn M., Ellington A.G., Frankland J.A., Fraser A., French L., Garner P.,
RA Grafham D.V., Griffiths C., Griffiths M.N.D., Gwilliam R., Hall R.E.,
RA Hammond S., Harley J.L., Heath P.D., Ho S., Holden J.L., Howden P.J.,
RA Huckle E., Hunt A.R., Hunt S.E., Jekosch K., Johnson C.M., Johnson D.,
RA Kay M.P., Kimberley A.M., King A., Knights A., Laird G.K., Lawlor S.,
RA Lehvaeslaiho M.H., Leversha M.A., Lloyd C., Lloyd D.M., Lovell J.D.,
RA Marsh V.L., Martin S.L., McConnachie L.J., McLay K., McMurray A.A.,
RA Milne S.A., Mistry D., Moore M.J.F., Mullikin J.C., Nickerson T.,
RA Oliver K., Parker A., Patel R., Pearce T.A.V., Peck A.I.,
RA Phillimore B.J.C.T., Prathalingam S.R., Plumb R.W., Ramsay H., Rice C.M.,
RA Ross M.T., Scott C.E., Sehra H.K., Shownkeen R., Sims S., Skuce C.D.,
RA Smith M.L., Soderlund C., Steward C.A., Sulston J.E., Swann R.M.,
RA Sycamore N., Taylor R., Tee L., Thomas D.W., Thorpe A., Tracey A.,
RA Tromans A.C., Vaudin M., Wall M., Wallis J.M., Whitehead S.L.,
RA Whittaker P., Willey D.L., Williams L., Williams S.A., Wilming L.,
RA Wray P.W., Hubbard T., Durbin R.M., Bentley D.R., Beck S., Rogers J.;
RT "The DNA sequence and comparative analysis of human chromosome 20.";
RL Nature 414:865-871(2001).
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M.,
RA Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J.,
RA Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S.,
RA Turner R., Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H.,
RA Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K.,
RA Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D.,
RA Hunkapiller M.W., Myers E.W., Venter J.C.;
RL Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases.
RN [5]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
RC TISSUE=Brain;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
CC -!- INTERACTION:
CC Q96N03; P54253: ATXN1; NbExp=9; IntAct=EBI-948213, EBI-930964;
CC Q96N03; Q9BSQ5: CCM2; NbExp=3; IntAct=EBI-948213, EBI-1573056;
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=3;
CC Name=1;
CC IsoId=Q96N03-1; Sequence=Displayed;
CC Name=2;
CC IsoId=Q96N03-2; Sequence=VSP_013380, VSP_026514;
CC Name=3;
CC IsoId=Q96N03-3; Sequence=VSP_026512, VSP_026513;
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DR EMBL; AK056177; BAB71113.1; -; mRNA.
DR EMBL; AL834410; CAD39072.2; -; mRNA.
DR EMBL; AL109964; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; CH471077; EAW76051.1; -; Genomic_DNA.
DR EMBL; CH471077; EAW76053.1; -; Genomic_DNA.
DR EMBL; BC033818; AAH33818.1; -; mRNA.
DR CCDS; CCDS13299.1; -. [Q96N03-1]
DR RefSeq; NP_542174.1; NM_080607.2. [Q96N03-1]
DR AlphaFoldDB; Q96N03; -.
DR BioGRID; 126121; 5.
DR IntAct; Q96N03; 2.
DR STRING; 9606.ENSP00000362560; -.
DR TCDB; 8.A.23.1.56; the basigin (basigin) family.
DR iPTMnet; Q96N03; -.
DR PhosphoSitePlus; Q96N03; -.
DR BioMuta; VSTM2L; -.
DR DMDM; 27151481; -.
DR EPD; Q96N03; -.
DR jPOST; Q96N03; -.
DR MassIVE; Q96N03; -.
DR MaxQB; Q96N03; -.
DR PaxDb; 9606-ENSP00000362560; -.
DR PeptideAtlas; Q96N03; -.
DR ProteomicsDB; 77436; -. [Q96N03-1]
DR ProteomicsDB; 77437; -. [Q96N03-2]
DR Antibodypedia; 26791; 54 antibodies from 17 providers.
DR DNASU; 128434; -.
DR Ensembl; ENST00000373459.4; ENSP00000362558.4; ENSG00000132821.12. [Q96N03-3]
DR Ensembl; ENST00000373461.9; ENSP00000362560.4; ENSG00000132821.12. [Q96N03-1]
DR Ensembl; ENST00000448944.1; ENSP00000406537.1; ENSG00000132821.12. [Q96N03-2]
DR GeneID; 128434; -.
DR KEGG; hsa:128434; -.
DR MANE-Select; ENST00000373461.9; ENSP00000362560.4; NM_080607.3; NP_542174.1.
DR UCSC; uc002xhk.5; human. [Q96N03-1]
DR AGR; HGNC:16096; -.
DR CTD; 128434; -.
DR DisGeNET; 128434; -.
DR GeneCards; VSTM2L; -.
DR HGNC; HGNC:16096; VSTM2L.
DR HPA; ENSG00000132821; Group enriched (brain, heart muscle, lymphoid tissue).
DR neXtProt; NX_Q96N03; -.
DR OpenTargets; ENSG00000132821; -.
DR PharmGKB; PA162408904; -.
DR VEuPathDB; HostDB:ENSG00000132821; -.
DR eggNOG; ENOG502RY0S; Eukaryota.
DR GeneTree; ENSGT00940000159381; -.
DR HOGENOM; CLU_1916373_0_0_1; -.
DR InParanoid; Q96N03; -.
DR OMA; HDMTARS; -.
DR OrthoDB; 4236279at2759; -.
DR PhylomeDB; Q96N03; -.
DR TreeFam; TF331739; -.
DR PathwayCommons; Q96N03; -.
DR SignaLink; Q96N03; -.
DR BioGRID-ORCS; 128434; 17 hits in 1147 CRISPR screens.
DR ChiTaRS; VSTM2L; human.
DR GenomeRNAi; 128434; -.
DR Pharos; Q96N03; Tdark.
DR PRO; PR:Q96N03; -.
DR Proteomes; UP000005640; Chromosome 20.
DR RNAct; Q96N03; Protein.
DR Bgee; ENSG00000132821; Expressed in right atrium auricular region and 133 other cell types or tissues.
DR Genevisible; Q96N03; HS.
DR GO; GO:0005737; C:cytoplasm; IDA:UniProtKB.
DR GO; GO:0005576; C:extracellular region; IDA:UniProtKB.
DR GO; GO:0043524; P:negative regulation of neuron apoptotic process; IDA:UniProtKB.
DR Gene3D; 2.60.40.10; Immunoglobulins; 1.
DR InterPro; IPR007110; Ig-like_dom.
DR InterPro; IPR036179; Ig-like_dom_sf.
DR InterPro; IPR013783; Ig-like_fold.
DR InterPro; IPR003599; Ig_sub.
DR InterPro; IPR013106; Ig_V-set.
DR PANTHER; PTHR12207; V-SET AND TRANSMEMBRANE DOMAIN-CONTAINING PROTEIN; 1.
DR PANTHER; PTHR12207:SF31; V-SET AND TRANSMEMBRANE DOMAIN-CONTAINING PROTEIN 2-LIKE PROTEIN; 1.
DR Pfam; PF07686; V-set; 1.
DR SMART; SM00409; IG; 1.
DR SUPFAM; SSF48726; Immunoglobulin; 1.
DR PROSITE; PS50835; IG_LIKE; 1.
PE 1: Evidence at protein level;
KW Alternative splicing; Disulfide bond; Immunoglobulin domain;
KW Reference proteome; Signal.
FT SIGNAL 1..24
FT /evidence="ECO:0000255"
FT CHAIN 25..204
FT /note="V-set and transmembrane domain-containing protein 2-
FT like protein"
FT /id="PRO_0000015164"
FT DOMAIN 41..158
FT /note="Ig-like"
FT REGION 168..204
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT DISULFID 62..142
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00114"
FT VAR_SEQ 41..132
FT /note="ALFTETPHDMTARTGEDVEMACSFRGSGSPSYSLEIQWWYVRSHRDWTDKQA
FT WASNQLKASQQEDAGKEATKISVVKVVGSNISHKLRLSRV -> GGQGGGQQHLPQAAP
FT VPGEAHGRRHLRVPRHRLQRRQGPAPQGQGLPAGAARGELRPASARSPSRRARPAAPQA
FT RQGAEEALGGPGGLQPLD (in isoform 3)"
FT /evidence="ECO:0000305"
FT /id="VSP_026512"
FT VAR_SEQ 98..114
FT /note="Missing (in isoform 2)"
FT /evidence="ECO:0000305"
FT /id="VSP_013380"
FT VAR_SEQ 133..204
FT /note="Missing (in isoform 3)"
FT /evidence="ECO:0000305"
FT /id="VSP_026513"
FT VAR_SEQ 167..204
FT /note="Missing (in isoform 2)"
FT /evidence="ECO:0000305"
FT /id="VSP_026514"
FT CONFLICT 139
FT /note="T -> S (in Ref. 5; AAH33818)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 204 AA; 22349 MW; 79917025B4C8425E CRC64;
MGAPLAVALG ALHYLALFLQ LGGATRPAGH APWDNHVSGH ALFTETPHDM TARTGEDVEM
ACSFRGSGSP SYSLEIQWWY VRSHRDWTDK QAWASNQLKA SQQEDAGKEA TKISVVKVVG
SNISHKLRLS RVKPTDEGTY ECRVIDFSDG KARHHKVKAY LRVQPGENSV LHLPEAPPAA
PAPPPPKPGK ELRKRSVDQE ACSL
//
