ID W0BF57_9GAMM Unreviewed; 455 AA.
AC W0BF57;
DT 19-MAR-2014, integrated into UniProtKB/TrEMBL.
DT 19-MAR-2014, sequence version 1.
DT 27-MAR-2024, entry version 33.
DE SubName: Full=NAD-dependent aldehyde dehydrogenase {ECO:0000313|EMBL:AHE67074.1};
DE EC=1.2.1.16 {ECO:0000313|EMBL:AHE67074.1};
GN ORFNames=Loa_01525 {ECO:0000313|EMBL:AHE67074.1};
OS Legionella oakridgensis ATCC 33761 = DSM 21215.
OC Bacteria; Pseudomonadota; Gammaproteobacteria; Legionellales;
OC Legionellaceae; Legionella.
OX NCBI_TaxID=1268635 {ECO:0000313|EMBL:AHE67074.1, ECO:0000313|Proteomes:UP000018838};
RN [1] {ECO:0000313|EMBL:AHE67074.1, ECO:0000313|Proteomes:UP000018838}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=OR-10, ATCC 33761 {ECO:0000313|Proteomes:UP000018838};
RX PubMed=23932911; DOI=10.1016/j.ijmm.2013.07.003;
RA Brzuszkiewicz E., Schulz T., Rydzewski K., Daniel R., Gillmaier N.,
RA Dittmann C., Holland G., Schunder E., Lautner M., Eisenreich W., Luck C.,
RA Heuner K.;
RT "Legionella oakridgensis ATCC 33761 genome sequence and phenotypic
RT characterization reveals its replication capacity in amoebae.";
RL Int. J. Med. Microbiol. 303:514-528(2013).
CC -!- SIMILARITY: Belongs to the aldehyde dehydrogenase family.
CC {ECO:0000256|ARBA:ARBA00009986, ECO:0000256|RuleBase:RU003345}.
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DR EMBL; CP004006; AHE67074.1; -; Genomic_DNA.
DR RefSeq; WP_025385679.1; NZ_CP004006.1.
DR AlphaFoldDB; W0BF57; -.
DR STRING; 1268635.Loa_01525; -.
DR KEGG; lok:Loa_01525; -.
DR PATRIC; fig|1268635.3.peg.1551; -.
DR eggNOG; COG1012; Bacteria.
DR HOGENOM; CLU_005391_1_0_6; -.
DR Proteomes; UP000018838; Chromosome.
DR GO; GO:0004030; F:aldehyde dehydrogenase [NAD(P)+] activity; IEA:InterPro.
DR GO; GO:0009013; F:succinate-semialdehyde dehydrogenase [NAD(P)+] activity; IEA:UniProtKB-EC.
DR CDD; cd07100; ALDH_SSADH1_GabD1; 1.
DR InterPro; IPR016161; Ald_DH/histidinol_DH.
DR InterPro; IPR016163; Ald_DH_C.
DR InterPro; IPR029510; Ald_DH_CS_GLU.
DR InterPro; IPR016162; Ald_DH_N.
DR InterPro; IPR015590; Aldehyde_DH_dom.
DR InterPro; IPR044148; ALDH_GabD1-like.
DR InterPro; IPR047110; GABD/Sad-like.
DR PANTHER; PTHR43217; SUCCINATE SEMIALDEHYDE DEHYDROGENASE [NAD(P)+] SAD; 1.
DR PANTHER; PTHR43217:SF1; SUCCINATE SEMIALDEHYDE DEHYDROGENASE [NAD(P)+] SAD; 1.
DR Pfam; PF00171; Aldedh; 1.
DR SUPFAM; SSF53720; ALDH-like; 1.
DR PROSITE; PS00687; ALDEHYDE_DEHYDR_GLU; 1.
PE 3: Inferred from homology;
KW Oxidoreductase {ECO:0000256|ARBA:ARBA00023002,
KW ECO:0000256|RuleBase:RU003345};
KW Reference proteome {ECO:0000313|Proteomes:UP000018838}.
FT DOMAIN 3..452
FT /note="Aldehyde dehydrogenase"
FT /evidence="ECO:0000259|Pfam:PF00171"
FT ACT_SITE 228
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU10007"
SQ SEQUENCE 455 AA; 50200 MW; A2B0913F8CBA644D CRC64;
MQIKTINPAT EEILQSYPLF KEEQVHAFID AAHLCYQAWR KTSFSQRRQR MLKMAELLRK
KQEEYAALMA KEMGKPLTAG KSEIEKCAWV CEHFAKQAEQ YLAPRLIQTE MTKTKVCYQP
LGVVFAIMPW NFPFWQVFRF AAPTIMAGNA AILKHAPIST GAGNAIAELF LEAGFPEHLF
QHFILDNELA AKVIANEKIV GVSLTGSEKA GSIVASHAAS HLKKSVLELG GNDPYIILAD
ADLELAANCV VTSRMNNSGQ VCIAAKRTIV VDEVVEEFVE HIVKLVEKFQ MGNPLDPSTN
FGPMARKDLR DTLHQQVLDS EKKGAKILRG GTVPHRKGFY YPPTILTNVS PGMPAFDDEL
FGPVIAIVSA EDEAHAIRLA NQSKYGLGGA VFTSDLARGE KIATEEIEVG SCFVNTYVAS
DPRVPFGGIK RSGFGREISR EGILEFVNTK TVSIK
//
