ID W0FMG4_9BACT Unreviewed; 1032 AA.
AC W0FMG4;
DT 19-MAR-2014, integrated into UniProtKB/TrEMBL.
DT 19-MAR-2014, sequence version 1.
DT 27-MAR-2024, entry version 22.
DE SubName: Full=Putative alpha-mannosidase {ECO:0000313|EMBL:AHF24654.1};
OS uncultured bacterium Contig13.
OC Bacteria; environmental samples.
OX NCBI_TaxID=1393410 {ECO:0000313|EMBL:AHF24654.1};
RN [1] {ECO:0000313|EMBL:AHF24654.1}
RP NUCLEOTIDE SEQUENCE.
RX PubMed=24223817;
RA Wang L., Hatem A., Catalyurek U.V., Morrison M., Yu Z.;
RT "Metagenomic insights into the carbohydrate-active enzymes carried by the
RT microorganisms adhering to solid digesta in the rumen of cows.";
RL PLoS ONE 8:E78507-E78507(2013).
CC -!- SIMILARITY: Belongs to the glycosyl hydrolase 38 family.
CC {ECO:0000256|ARBA:ARBA00009792}.
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DR EMBL; KC246801; AHF24654.1; -; Genomic_DNA.
DR AlphaFoldDB; W0FMG4; -.
DR GO; GO:0004559; F:alpha-mannosidase activity; IEA:InterPro.
DR GO; GO:0030246; F:carbohydrate binding; IEA:InterPro.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0006013; P:mannose metabolic process; IEA:InterPro.
DR CDD; cd10789; GH38N_AMII_ER_cytosolic; 1.
DR Gene3D; 2.60.40.2220; -; 1.
DR Gene3D; 3.20.110.10; Glycoside hydrolase 38, N terminal domain; 1.
DR Gene3D; 1.20.1270.50; Glycoside hydrolase family 38, central domain; 1.
DR InterPro; IPR011013; Gal_mutarotase_sf_dom.
DR InterPro; IPR041147; GH38_C.
DR InterPro; IPR011330; Glyco_hydro/deAcase_b/a-brl.
DR InterPro; IPR011682; Glyco_hydro_38_C.
DR InterPro; IPR015341; Glyco_hydro_38_cen.
DR InterPro; IPR037094; Glyco_hydro_38_cen_sf.
DR InterPro; IPR000602; Glyco_hydro_38_N.
DR InterPro; IPR027291; Glyco_hydro_38_N_sf.
DR InterPro; IPR028995; Glyco_hydro_57/38_cen_sf.
DR PANTHER; PTHR46017; ALPHA-MANNOSIDASE 2C1; 1.
DR PANTHER; PTHR46017:SF1; ALPHA-MANNOSIDASE 2C1; 1.
DR Pfam; PF09261; Alpha-mann_mid; 1.
DR Pfam; PF17677; Glyco_hydro38C2; 1.
DR Pfam; PF07748; Glyco_hydro_38C; 1.
DR Pfam; PF01074; Glyco_hydro_38N; 1.
DR SMART; SM00872; Alpha-mann_mid; 1.
DR SUPFAM; SSF88688; Families 57/38 glycoside transferase middle domain; 1.
DR SUPFAM; SSF74650; Galactose mutarotase-like; 1.
DR SUPFAM; SSF88713; Glycoside hydrolase/deacetylase; 1.
PE 3: Inferred from homology;
KW Glycosidase {ECO:0000256|ARBA:ARBA00023295};
KW Hydrolase {ECO:0000256|ARBA:ARBA00023295};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723}.
FT DOMAIN 524..597
FT /note="Glycoside hydrolase family 38 central"
FT /evidence="ECO:0000259|SMART:SM00872"
SQ SEQUENCE 1032 AA; 115998 MW; AE409CF1FC30DF8A CRC64;
MKYMHSEWRR RLDHWIGTLK KDLYLPLGEI PVAGFMTCDH LTPEEAARQT FTPMVPGQAW
GRAWEYCWMR GSVTLPEEAA GRRVVMDLNT GGETTVFVNG KSFGTYRAEW VEEPHHYIED
NVLASRGEPG RTYELLLEAY AGHYYPQSSM GGCATGPVLP GSYADPMEGK PRAVLGNMTY
GIWNEDAYQL YMDLQTLNLL MDQVDPESLR ADRLASALEQ ATLIVDFEQP LAERIASYRA
AREALKPALS AVNGTTAPLF YAVGNAHLDL AWLWPMAETR RKTSRTFAAQ LRLIEEYPEY
KYIQSQPAAY VMCREHYPEL YERIRQAVKN GQWIAEGAMW VEPDTNMTGG ESLVRQLIHG
KRFFREEFGV DSVILWLPDT FGYSAALPQI LQGCGVKYLV TQKIFWSYNE GDRFPYHYFT
WQGADGSKVT SFLPTSYTYK TDPGEICETW KKRVQKRGLE AFLLPFGYGD GGGGPARDYV
EFLRREENLE GMPRVITESP VKFFEDMEAA GGPQHTYVGE LYFSAHRGVY TSQAVVKRGN
RKAEIALREA EMWGALTEDY PLARMDAAWK RLLLNQFHDI LPGSSIAKVY EDARRDHRWI
ISEAVAVRDA ALAGLARGGG VTVFNSLSFD RAGLVKLPPE YADGAVSADG QAVPVQQTAD
GLLGRVSVPA CGAVSLKPRK VKKQVSAFAG KENDQFVLEN EFVRAAVSNR GEVISFTDKK
TGRDFAAAPM NRLLMFKDVP RMFDAWDIDS NYILQPIALN EPVDVTISEE NGLRAVLHVE
RSIQDSVFAQ DIVLCAGSRR LDFVTRIDWR ELHRLLKVEF PVDVQAAEGI NEIQFGYMAR
PTHRSRLYDS DRFEVCNQRY SALCDQSHGA AVLNDCKYGI SMNGNSLQLT LLRAAACPEM
PADNGEHTFT YAFTAWEGSF LDSPVVREAY DLNVPLQAAP GHCPVFSAFR PDAANVFIDT
VKPAEDGSGD IILRLYEAKR ADTACRLALG IPAKSVFLCD MLETTREELP IHQHAVSLRF
RTFEVKTLRI KR
//
